Inspection of endothelial nitric oxide synthase gene polymorphism in patients with henoch schönlein purpura

Makbule Nihan SOMUNCU, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Konya, Türkiye)
Mahmut Selaman YILDIRIM, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Konya, Türkiye)
Ayşegül ZAMANİ, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Konya, Türkiye)
Harun PERU (Selçuk Üniversitesi, Selçuklu Tıp Fakültesi, Nefroloji Anabilim Dalı, Konya, Türkiye)
Archives of Rheumatology
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Yıl: 2014 Cilt: 29 Sayı: 2 Sayfa Aralığı: 73 - 80 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Inspection of endothelial nitric oxide synthase gene polymorphism in patients with henoch schönlein purpura

Öz:
Objectives: This study aims to investigate the effect of Glu298Asp polymorphism, which is observed at endothelial nitric oxide synthase isoform particularly, having a significant impact on endothelial functions of nitric oxide synthase gene and on vascular system in patients with Henoch Schönlein purpura (HSP). Patients and methods: Ninety-five patients who were diagnosed with HSP and 93 healthy controls without any previous vascular disease, hypertension and other cardiovascular diseases were included in this study. The patient group was compared with the controls for Glu298Asp genotype and allele frequencies. The patients were classified according to the clinical complications and were compared with controls and also each other for allele and genotype frequencies. Real-time polymerase chain reaction and LightCycler 2.0 system were used. Results: There was no statistically significant difference in the genotype frequencies between the HSP patients and healthy controls. No significant differences in Glu298Asp gene polymorphism among the patient groups were observed. However, polymorphism had an significant effect on patients with all involvements statistically (P TT=0.001, PGG=0.000). Conclusion: We conclude that Glu298Asp polymorphism has no effect on the development of HSP vasculitis; however, it may have an impact on the clinical progress of the existing disease.
Anahtar Kelime:

Konular: Romatoloji
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Somuncu M, YILDIRIM M, ZAMANİ A, PERU H (2014). Inspection of endothelial nitric oxide synthase gene polymorphism in patients with henoch schönlein purpura. , 73 - 80.
Chicago Somuncu Makbule Nihan,YILDIRIM Mahmut Selaman,ZAMANİ Ayşegül,PERU Harun Inspection of endothelial nitric oxide synthase gene polymorphism in patients with henoch schönlein purpura. (2014): 73 - 80.
MLA Somuncu Makbule Nihan,YILDIRIM Mahmut Selaman,ZAMANİ Ayşegül,PERU Harun Inspection of endothelial nitric oxide synthase gene polymorphism in patients with henoch schönlein purpura. , 2014, ss.73 - 80.
AMA Somuncu M,YILDIRIM M,ZAMANİ A,PERU H Inspection of endothelial nitric oxide synthase gene polymorphism in patients with henoch schönlein purpura. . 2014; 73 - 80.
Vancouver Somuncu M,YILDIRIM M,ZAMANİ A,PERU H Inspection of endothelial nitric oxide synthase gene polymorphism in patients with henoch schönlein purpura. . 2014; 73 - 80.
IEEE Somuncu M,YILDIRIM M,ZAMANİ A,PERU H "Inspection of endothelial nitric oxide synthase gene polymorphism in patients with henoch schönlein purpura." , ss.73 - 80, 2014.
ISNAD Somuncu, Makbule Nihan vd. "Inspection of endothelial nitric oxide synthase gene polymorphism in patients with henoch schönlein purpura". (2014), 73-80.
APA Somuncu M, YILDIRIM M, ZAMANİ A, PERU H (2014). Inspection of endothelial nitric oxide synthase gene polymorphism in patients with henoch schönlein purpura. Archives of Rheumatology, 29(2), 73 - 80.
Chicago Somuncu Makbule Nihan,YILDIRIM Mahmut Selaman,ZAMANİ Ayşegül,PERU Harun Inspection of endothelial nitric oxide synthase gene polymorphism in patients with henoch schönlein purpura. Archives of Rheumatology 29, no.2 (2014): 73 - 80.
MLA Somuncu Makbule Nihan,YILDIRIM Mahmut Selaman,ZAMANİ Ayşegül,PERU Harun Inspection of endothelial nitric oxide synthase gene polymorphism in patients with henoch schönlein purpura. Archives of Rheumatology, vol.29, no.2, 2014, ss.73 - 80.
AMA Somuncu M,YILDIRIM M,ZAMANİ A,PERU H Inspection of endothelial nitric oxide synthase gene polymorphism in patients with henoch schönlein purpura. Archives of Rheumatology. 2014; 29(2): 73 - 80.
Vancouver Somuncu M,YILDIRIM M,ZAMANİ A,PERU H Inspection of endothelial nitric oxide synthase gene polymorphism in patients with henoch schönlein purpura. Archives of Rheumatology. 2014; 29(2): 73 - 80.
IEEE Somuncu M,YILDIRIM M,ZAMANİ A,PERU H "Inspection of endothelial nitric oxide synthase gene polymorphism in patients with henoch schönlein purpura." Archives of Rheumatology, 29, ss.73 - 80, 2014.
ISNAD Somuncu, Makbule Nihan vd. "Inspection of endothelial nitric oxide synthase gene polymorphism in patients with henoch schönlein purpura". Archives of Rheumatology 29/2 (2014), 73-80.
Sayfa Oluşturulma Tarihi
22-04-2024 20:49

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