Beneficial Effects of Moxonidine on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage

KOCAOĞULLAR, Yalçın; Koç, Osman; ESEN, Hasan; ILIK, Mustafa Kemal

Beneficial Effects of Moxonidine on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage

Mustafa Kemal ILIK, (Mevlana Üniversitesi, Tıp, Fakültesi, Konya, Türkiye)

Yalçın KOCAOĞULLAR, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Konya, Türkiye)

Osman KOÇ, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Konya, Türkiye)

Hasan ESEN (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Konya, Türkiye)

Turkish Neurosurgery

3 0

Yıl: 2014 Cilt: 24 Sayı: 6 Sayfa Aralığı: 873 - 879 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Beneficial Effects of Moxonidine on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage

Öz:

AMAÇ: Çalışma I1-imidazolin bölgeleri için selektif bir ligand olan merkezi etkili antihipertansif ajan moksonidinin bir tavşan serebralvazospazm modelinde etkinliğini incelemek üzere tasarlanmıştır. YÖNTEM ve GEREÇlER: Yirmi dört beyaz, 2500-3200 gr. ağırlığında erkek, Yeni Zelanda tavşanı rasgele olarak üç gruba bölünmüştür grup 1=kontrol grubu, grup 2=sadece subaraknoid kanama (SAK) grubu ve grup 3=SAK + moksonidin (tedavi) grubu. Tüm tavşanlarda SAK indüksiyonu öncesinde (Gün=0, bazal anj iyografi) ve 72 saat sonrasında serebral anj iyografi yapılmıştır. SAKindüksiyonundan sonra tedavi grubunda intraperitoneal moksonidin (0,5 mg/kg) tedavisi başlatılmış ve günde bir kez olmak üzere 72 saatdevam ettirilmiştir. BULGULAR: Gruplar arasında baziller arterin anj iyografik luminal çapı açısından istatistiksel olarak önemli bir fark bulunmamıştır (p>0,005).SAK sonrasında takip anj iyografik baziller arter luminal çapı sadece SAK grubu ile karşılaştırıldığında tedavi grubunda istatistiksel olarakanlamlı şekilde değişiklik göstermiştir (p<0,001). Patoloj ik olarak incelenen baziller arter lümeni alanı bu iki grup arasında istatistiksel açıdananlamlı fark göstermiştir (p<0,005). SONUÇ: Merkezi etkili bir antihipertansif ajan olarak moksonidin tedavisi anj iyografik çapı ve patoloj ide lümen alanını artırıp müsküler duvarkalınlığını azaltarak vazospazm tedavisinde çok faydalı bulunmuştur.

Anahtar Kelime:

Konular: Cerrahi

Deneysel Subaraknoid Kanamadan Sonra Serebral Vazospazm Üzerine Moksonidin in Fay dalı Etkisi

Öz:

AIM: This study was designed to examine the efficacy of moxonidine, a centrally acting antihypertensive agent that is a selective ligand forI1-imidazoline sites, in a rabbit cerebral vasospasm model. MATERIAL and METHODS: Twenty-four white, male New-Zealand rabbits weighing 2500-3200 gr. were randomly allocated into three groupsas group 1= control group, group 2=subarachnoid hemorrhage (SAH) alone group, and group 3=SAH + moxonidine (treatment) group.Cerebral angiography was performed to all rabbits before (Day=0, basal angiography) and 72 hours after the induction of SAH. Intraperitonealmoxonidine (0.5 mg/kg) treatment was started after the induction of SAH and continued once a day for 72 hours in the treatment group. RESULTS: No statistically significant difference was determined in basal angiographic luminal diameter of the basilar artery between groups(p>0.005). After SAH, the follow-up angiographic basilar artery luminal diameter significantly changed in treatment group when comparedwith the SAH alone group (p<0.001). The pathologically examined basilar artery luminal area was different between these groups (p<0.005). CONCLUSION: Moxonidine treatment as a centrally acting antihypertensive agent was found to be very beneficial in the treatment ofvasospasm by increasing the angiographic diameter and the pathologic luminal area and reducing muscular wall thickness.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ILIK M, KOCAOĞULLAR Y, Koç O, ESEN H (2014). Beneficial Effects of Moxonidine on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage. , 873 - 879.
Chicago	ILIK Mustafa Kemal,KOCAOĞULLAR Yalçın,Koç Osman,ESEN Hasan Beneficial Effects of Moxonidine on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage. (2014): 873 - 879.
MLA	ILIK Mustafa Kemal,KOCAOĞULLAR Yalçın,Koç Osman,ESEN Hasan Beneficial Effects of Moxonidine on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage. , 2014, ss.873 - 879.
AMA	ILIK M,KOCAOĞULLAR Y,Koç O,ESEN H Beneficial Effects of Moxonidine on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage. . 2014; 873 - 879.
Vancouver	ILIK M,KOCAOĞULLAR Y,Koç O,ESEN H Beneficial Effects of Moxonidine on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage. . 2014; 873 - 879.
IEEE	ILIK M,KOCAOĞULLAR Y,Koç O,ESEN H "Beneficial Effects of Moxonidine on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage." , ss.873 - 879, 2014.
ISNAD	ILIK, Mustafa Kemal vd. "Beneficial Effects of Moxonidine on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage". (2014), 873-879.

APA	ILIK M, KOCAOĞULLAR Y, Koç O, ESEN H (2014). Beneficial Effects of Moxonidine on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage. Turkish Neurosurgery, 24(6), 873 - 879.
Chicago	ILIK Mustafa Kemal,KOCAOĞULLAR Yalçın,Koç Osman,ESEN Hasan Beneficial Effects of Moxonidine on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage. Turkish Neurosurgery 24, no.6 (2014): 873 - 879.
MLA	ILIK Mustafa Kemal,KOCAOĞULLAR Yalçın,Koç Osman,ESEN Hasan Beneficial Effects of Moxonidine on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage. Turkish Neurosurgery, vol.24, no.6, 2014, ss.873 - 879.
AMA	ILIK M,KOCAOĞULLAR Y,Koç O,ESEN H Beneficial Effects of Moxonidine on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage. Turkish Neurosurgery. 2014; 24(6): 873 - 879.
Vancouver	ILIK M,KOCAOĞULLAR Y,Koç O,ESEN H Beneficial Effects of Moxonidine on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage. Turkish Neurosurgery. 2014; 24(6): 873 - 879.
IEEE	ILIK M,KOCAOĞULLAR Y,Koç O,ESEN H "Beneficial Effects of Moxonidine on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage." Turkish Neurosurgery, 24, ss.873 - 879, 2014.
ISNAD	ILIK, Mustafa Kemal vd. "Beneficial Effects of Moxonidine on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage". Turkish Neurosurgery 24/6 (2014), 873-879.