Yıl: 2015 Cilt: 7 Sayı: 3 Sayfa Aralığı: 222 - 227 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Assessment of Cardiovascular Parameters in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease

Öz:
Objective: The aim of this study was to evaluate the periaortic fat thickness (PAFT) using conventional echocardiography in obese children and adolescents with non-alcoholic fatty liver disease (NAFLD).Methods: Two hundred and ninety-seven obese children and adolescents were included in the study. Anthropometric measurements were made in all subjects, and fasting venous blood samples were taken for determination of glucose, insulin, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. Ultrasonography of the liver was used for assessment of NAFLD and the subjects were grouped as NAFLD and non-NAFLD. Echocardiography was performed in all subjects.Results: PAFT was higher in patients with NAFLD compared with the nonNAFLD group. In patients with NAFLD, PAFT was positively correlated with waist circumference and with total cholesterol levels. In multiple regression analysis, waist circumference (?=0.28, p=<0.001) was found to be the best predictor of PAFT.Conclusion: Conventional echocardiography may be used to determine increased PAFT at an early stage in obese children and adolescents with NAFLD for careful monitoring of cardiovascular risk
Anahtar Kelime:

Konular: Endokrinoloji ve Metabolizma Pediatri
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • Fu JF, Shi HB, Liu LR, Jiang P, Liang L, Wang CL, Liu XY. Non-alcoholic fatty liver disease: An early mediator predicting metabolic syndrome in obese children? World J Gastroenterol 2011;17:735-742.
  • Hamaguchi M, Takeda N, Kojima T, Ohbora A, Kato T, Sarui H, Fukui M, Nagata C, Takeda J. Identification of individuals with non-alcoholic fatty liver disease by the diagnostic criteria for the metabolic syndrome. World J Gastroenterol 2012;18:1508-1516.
  • Donati G, Stagni B, Piscaglia F, Venturoli N, Morselli-Labate AM, Rasciti L, Bolondi L. Increased prevalence of fatty liver in arterial hypertensive patients with normal liver enzymes: role of insulin resistance. Gut 2004;53:1020-1023.
  • Pacifico L, Nobili V, Anania C, Verdecchia P, Chiesa C. Pediatric non alcoholic fatty liver disease, metabolic syndrome and cardiovascular risk.World J Gastroenterol 2011;17: 3082-3091.
  • Britton KA, Pedley A, Massaro JM, Corsini EM, Murabito JM, Hoffmann U, Fox CS. Prevalence, distribution, and risk factor correlates of high thoracic periaortic fat in the Framingham Heart Study. J Am Heart Assoc 2012;1:004200. Epub 2012 Dec 19
  • Spiroglou SG, Kostopoulos CG, Varakis JN, Papadaki HH. Adipokines in periaortic and epicardial adipose tissue: differential expression and relation to atherosclerosis. J Atheroscler Thromb 2010;17:115-130. Epub 2010 Feb 10
  • Akın L, Kurtoglu S, Yikilmaz A, Kendirci M, Elmalı F, Mazicioglu M. Fatty liver is a good indicator of subclinical atherosclerosis risk in obese children and adolescents regardless of liver enzyme elevation. Acta Paediatr 2013;102:107-113. Epub 2012 Dec 29
  • Bundak R, Furman A, Gunoz H, Darendeliler F, Bas F, Neyzi O. Body mass index references for Turkish children. Acta Paediatr 2006;95:194-198.
  • Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970;45:13-23.
  • Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child 1969;44:291-303.
  • Hatipoglu N, Ozturk A, Mazicioglu MM, Kurtoglu S, Seyhan S, Lokoglu F. Waist circumference percentiles for 7- to 17-year-old Turkish children and adolescents. Eur J Pediatr 2008;167:383-389. Epub 2007 May 9
  • National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114(Suppl 2):555-576.
  • Güngör NK. Overweight and obesity in children and adolescents. J Clin Res Pediatr Endocrinol 2014;6:129-143.
  • Conwell LS, Trost SG, Brown WJ, Batch JA. Indexes of insulin resistance and secretion in obese children and adolescents: a validation study. Diabetes Care 2004;27: 314-319.
  • Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005;115:500-503. Epub 2005 Mar 1
  • Gilardini L, Pasqualinotto L, Di Matteo S, Caffetto K, Croci M, Girola A, Invitti C. Factors associated with early atherosclerosis and arterial calcifications in young subjects with a benign phenotype of obesity. Obesity (Silver Spring) 2011;19:1684-1689.
  • Berenson GS, Srinivasan SR, Bao W, Newman WP 3rd, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med 1998;338:1650-1656.
  • Pacifico L, Cantisani V, Ricci P, Osborn JF, Schiavo E, Anania C, Ferrara E, Dvisic G, Chiesa C. Nonalcoholic fatty liver disease and carotid atherosclerosis in children. Pediatr Res 2008;63:423-427.
  • Dick TJ, Lesser IA, Leipsic JA, Mancini GB, Lear SA. The effect of obesity on the association between liver fat and carotid atherosclerosis in a multi-ethnic cohort. Atherosclerosis 2013;226:208-213.
  • Akabame S, Hamaguchi M, Tomiyasu K, Tanaka M, Kobayashi- Takenaka Y, Nakano K, Oda Y, Yoshikawa T. Evaluation of vulnerable coronary plaques and non-alcoholic fatty liver disease (NAFLD) by 64-detector multislice computed tomography (MSCT). Circ J 2008;72:618-625.
  • Loria P, Lonardo A, Targher G. Is liver fat detrimental to vessels?: intersections in the pathogenesis of NAFLD and atherosclerosis. Clin Sci (Lond) 2008;115:1-12.
  • Alisi A, Manco M, Vania A, Nobili V. Pediatric nonalcoholic fatty liver disease in 2009. J Pediatr 2009;155:469-474.
  • Sert A, Pirgon O, Aypar E. Relationship between aspartate aminotransferase-to-platelet ratio index and carotid intima- media thickness in obese adolescents with non-alcoholic fatty liver disease. J Clin Res Pediatr Endocrinol 2013;5:182-188.
  • Schwimmer JB, McGreal N, Deutsch R, Finegold MJ, Lavine JE. Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents. Pediatrics 2005;115:561- 565.
  • Fracanzani AL, Burdick L, Raselli S, Pedotti P, Grigore L, Santorelli G, Valenti L, Maraschi A, Catapano A, Fargion S. Carotid artery intima-media thickness in nonalcoholic fatty liver disease. Am J Med 2008;121:72-78.
  • Cook S, Auinger P, Li C, Ford ES. Metabolic syndrome rates in United States adolescents, from the National Health and Nutrition Examination Survey, 1999-2002. J Pediatr 2008;152:165-170. Epub 2007 Oct 22
  • Fallo F, Dalla Pozza A, Sonino N, Lupia M, Tona F, Federspil G, Ermani M, Catena C, Soardo G, Di Piazza L, Bernardi S, Bertolotto M, Pinamonti B, Fabris B, Sechi LA. Non- alcoholic fatty liver disease is associated with left ventricular diastolic dysfunction in essential hypertension. Nutr Metab Cardiovasc Dis 2009;19:646-653. Epub 2009 Mar 17
  • Hurjui DM, Nita O, Graur LI, Mihalache L, Popescu DS, Hutanaşu IC, Ungureanu D, Graur M. Non-alcoholic fatty liver disease is associated with cardiovascular risk factors of metabolic syndrome. Rev Med Chir Soc Med Nat Iasi 2012;116:692-699.
  • Alam S, Noor-E-Alam SM, Chowdhury ZR, Alam M, Kabir J. Nonalcoholic steatohepatitis in nonalcoholic fatty liver disease patients of Bangladesh. World J Hepatol 2013;5:281-287.
  • Peterson LR, Herrero P, Schechtman KB, Racette SB, Waggoner AD, Kisrieva-Ware Z, Dence C, Klein S, Marsala J, Meyer T, Gropler RJ. Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women. Circulation 2004;109:2191- 2196. Epub 2004 May 3
  • Atabek ME. Possible misinterpretations of nonalcoholic fatty liver disease and intra-abdominal fat in prepubertal children born small for gestational age. Horm Res Paediatr 2013;80:134. Epub 2013 Jun 20
APA SELVER EKLİOĞLU B, Atabek M, akyurek n, Alp H (2015). Assessment of Cardiovascular Parameters in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease. , 222 - 227.
Chicago SELVER EKLİOĞLU BERAY,Atabek Mehmet Emre,akyurek nesibe,Alp Hayrullah Assessment of Cardiovascular Parameters in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease. (2015): 222 - 227.
MLA SELVER EKLİOĞLU BERAY,Atabek Mehmet Emre,akyurek nesibe,Alp Hayrullah Assessment of Cardiovascular Parameters in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease. , 2015, ss.222 - 227.
AMA SELVER EKLİOĞLU B,Atabek M,akyurek n,Alp H Assessment of Cardiovascular Parameters in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease. . 2015; 222 - 227.
Vancouver SELVER EKLİOĞLU B,Atabek M,akyurek n,Alp H Assessment of Cardiovascular Parameters in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease. . 2015; 222 - 227.
IEEE SELVER EKLİOĞLU B,Atabek M,akyurek n,Alp H "Assessment of Cardiovascular Parameters in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease." , ss.222 - 227, 2015.
ISNAD SELVER EKLİOĞLU, BERAY vd. "Assessment of Cardiovascular Parameters in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease". (2015), 222-227.
APA SELVER EKLİOĞLU B, Atabek M, akyurek n, Alp H (2015). Assessment of Cardiovascular Parameters in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease. Journal of Clinical Research in Pediatric Endocrinology, 7(3), 222 - 227.
Chicago SELVER EKLİOĞLU BERAY,Atabek Mehmet Emre,akyurek nesibe,Alp Hayrullah Assessment of Cardiovascular Parameters in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease. Journal of Clinical Research in Pediatric Endocrinology 7, no.3 (2015): 222 - 227.
MLA SELVER EKLİOĞLU BERAY,Atabek Mehmet Emre,akyurek nesibe,Alp Hayrullah Assessment of Cardiovascular Parameters in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease. Journal of Clinical Research in Pediatric Endocrinology, vol.7, no.3, 2015, ss.222 - 227.
AMA SELVER EKLİOĞLU B,Atabek M,akyurek n,Alp H Assessment of Cardiovascular Parameters in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease. Journal of Clinical Research in Pediatric Endocrinology. 2015; 7(3): 222 - 227.
Vancouver SELVER EKLİOĞLU B,Atabek M,akyurek n,Alp H Assessment of Cardiovascular Parameters in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease. Journal of Clinical Research in Pediatric Endocrinology. 2015; 7(3): 222 - 227.
IEEE SELVER EKLİOĞLU B,Atabek M,akyurek n,Alp H "Assessment of Cardiovascular Parameters in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease." Journal of Clinical Research in Pediatric Endocrinology, 7, ss.222 - 227, 2015.
ISNAD SELVER EKLİOĞLU, BERAY vd. "Assessment of Cardiovascular Parameters in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease". Journal of Clinical Research in Pediatric Endocrinology 7/3 (2015), 222-227.