Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents

Atabek, Mehmet Emre; Alp, Hayrullah; SELVER EKLİOĞLU, BERAY; akyurek, nesibe

Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents

Beray Selver EKLİOĞLU, (Necmettin Erbakan Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Pediatrik Endokrinoloji ve Diyabet Bölümü, Konya, Türkiye)

Mehmet Emre ATABEK, (Necmettin Erbakan Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Pediatrik Endokrinoloji ve Diyabet Bölümü, Konya, Türkiye)

Nesibe AKYÜREK, (Konya Eğitim ve Araştırma Hastanesi, Çocuk Endokrinoloji ve Diyabet Kliniği, Konya, Türkiye)

Hayrullah ALP (Malatya Devlet Hastanesi, Pediatrik Kardiyoloji Kliniği, Malatya, Türkiye)

Journal of Clinical Research in Pediatric Endocrinology

1 0

Yıl: 2016 Cilt: 8 Sayı: 1 Sayfa Aralığı: 80 - 85 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents

Öz:

Objective: In this study, our aim was to determine cardiovascular risk and cardiac function in prediabetic obese children and adolescents. Methods: The study was conducted on 198 obese children and adolescents 6-18 years of age. Anthropometric measurements, blood pressure measurements, oral glucose tolerance test, lipid profile, and HbA1c levels of patients were assessed. Prediabetes was defined according to American Diabetes Association criteria. Left ventricular mass index (LVMi), carotid intima-media thickness (c-IMT), and tissue Doppler measurements records were used.Results: LVMi was found to be significantly higher in the prediabetes group (p=0.03). There were no statistically significant differences in right ventricular tissue Doppler measurements between the prediabetic and non-prediabetic groups. Left ventricular tissue Doppler measurements were significantly higher in the prediabetes group: LVEEM (left ventricular E/e ratio) (p=0.04); LVEM (left ventricular myocardial velocity cm/s) (p=0.035). LVMi was found to positively correlate with triglyceride level, diastolic blood pressure, waist circumference, body weight standard deviation score and to negatively correlate with high-density lipoprotein cholesterol (p=0.043, r=0.15; p=0.039, r=0.15; p=0.025, r=0.17; p=0.009, r=0.19; p=0.038, r=-0.15, respectively). LVEM was correlated with glucose (p=0.046, r=0.15) and LVEEM was correlated with systolic blood pressure (p=0.035, r=0.15). In linear regression analysis for clinical cardiovascular risk factors, fasting glucose level was the best predictor of LVEM.Conclusion: In this study, deterioration of cardiac function in prediabetic obese children and adolescents was shown. We recommend determining cardiovascular risk and cardiac dysfunction at early stages in prediabetic obese children and adolescents.

Anahtar Kelime:

Konular: Endokrinoloji ve Metabolizma Pediatri

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

Bereket A, Atay Z. Current status of childhood obesity and its associated morbidities in Turkey. J Clin Res Pediatr Endocrinol 2012;4:1-7.
Porcar-Almela M, Codoñer-Franch P, Tuzón M, Navarro-Solera M, Carrasco-Luna J, Ferrando J. Left ventricular diastolic function and cardiometabolic factors in obese normotensive children. Nutr Metab Cardiovasc Dis 2015;25:108-115. Epub 2014 Sep 19
Kharod AM, Ramlogan SR, Kumar S, Raghuveer T, Drake W, Dai H, Raghuveer G.Childhood obesity increases left- ventricular mass irrespective of blood pressure status. Pediatr Cardiol 2014;35:353-360. Epub 2013 Aug 30
Erkoçoğlu M, Ozön ZA, Göçmen R, Alikaşifoğlu A, Gönç N, Kandemir N. Carotid intima media thickness in adolescents with increased risk for atherosclerosis. Turk J Pediatr 2013;55:510-518.
Boyraz M, Pirgon O, Akyol B, Dundar B, Cekmez F, Eren N. Importance of epicardial adipose tissue thickness measurement in obese adolescents, its relationship with carotid intima-media thickness, and echocardiographic findings. Eur Rev Med Pharmacol Sci 2013;17:3309-3317.
Alpsoy S, Akyüz A, Akkoyun DC, Nalbantoğlu B, Topçu B, Değirmenci H, Ozdilek B, Donma MM. Effect of overweight on cardiac function in children. Turk Kardiyol Dern Ars 2013;41:714-723.
Kibar AE, Pac FA, Ballı S, Oflaz MB, Ece I, Bas VN, Aycan Z. Early subclinical left-ventricular dysfunction in obese nonhypertensive children: a tissue Doppler imaging study. Pediatr Cardiol 2013;34:1482-1490.
Aslan AN, Ayhan H, Çiçek ÖF, Akçay M, Durmaz T, Keles T, Çakır B, Bozkurt E. Relationship between aortic stiffness and the left ventricular function in patients with prediabetes. Intern Med 2014;53:1477-1484. Epub 2014 Jul 15
Kuczmarski RJ, Ogden CL, Guo SS, Grummer-Strawn LM, Flegal KM, Mei Z, Wei R, Curtin LR, Roche AF, Johnson CL. 2000 CDC Growth Charts for the United States: methods and development. Vital Health Stat 11 2002;246:1-190.
Hatipoglu N, Ozturk A, Mazicioglu MM, Kurtoglu S, Seyhan S, Lokoglu F. Waist circumference percentiles for 7- to 17-year-old Turkish children and adolescents. Eur J Pediatr 2008;167:383-389. Epub 2007 May 9
Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970;45:13-23.
Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in girls. Arch Dis Child 1969;44:291-303.
National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114:555-576
Conwell LS, Trost SG, Brown WJ, Batch JA. Indexes of insulin resistance and secretion in obese children and adolescents: a validation study. Diabetes Care 2004;27:314-319.
Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese childrenand adolescents. Pediatrics 2005;115:500-503. Epub 2005 Mar 1
The Oxford Centre for Diabetes. Endocrinology & Metabolism. Diabetes Trial Unit. HOMA Calculator. Available from: https:// www.dtu.ox.ac.uk/homacalculator/download.php
American Diabetes Association. (2) Classification and diagnosis of diabetes. Diabetes Care 2015;38:8-16.
Lopez L, Colan SD, Frommelt PC, Ensing GJ, Kendall K, Younoszai AK, Lai WW, Geva T. Recommendations for quantification methods during the performance of a pediatric echocardiogram: a report from the Pediatric Measurements Writing Group of the American Society of Echocardiography Pediatric and Congenital Heart Disease Council. J Am Soc Echocardiogr 2010;23:465-495.
Devereux RB, Reichek N. Echocardiographic determination of leftventricular mass in man. Anatomic validation of the method. Circulation 1977; 55:613-618.
de Simone G, Daniels SR, Devereux RB, Meyer RA, Roman MJ, de Divitiis O, Alderman MH. Left ventricular mass and body size in normotensive children and adults: assessment of allometric relations and impact of overweight. J Am Coll Cardiol 1992;20:1251-1260.
Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N, Csiba L, Desvarieux M, Ebrahim S, Fatar M, Hernandez Hernandez R, Jaff M, Kownator S, Prati P, Rundek T, Sitzer M, Schminke U, Tardif JC, Taylor A, Vicaut E, Woo KS, Zannad F, Zureik M. Mannheim carotid intima-media thickness consensus (2004-2006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006. Cerebrovasc Dis 2007;23:75-80. Epub 2006 Nov 14
Tei C. New noninvasive index for combined systolic and diastolicventricular function. J Cardiol 1995;26:135-136.
Haemer MA, Grow HM, Fernandez C, Lukasiewicz GJ, Rhodes ET, Shaffer LA, Sweeney B, Woolford SJ, Estrada E. Addressing prediabetes in childhood obesity treatment programs: support from research and current practice. Child Obes 2014;10:292-303. Epub 2014 Jul 23
Kurtoglu S, Hatipoglu N, Mazicioglu MM, Kendirci M, Keskin M, Kondolot M. Insulin resistance in obese childrenand adolescents: HOMA- IR cut-off levels in the prepubertal and pubertal periods. J Clin Res Pediatr Endocrinol 2010;2:100- 106. Epub 2010 Aug 2
Brar PC, Mengwall L, Franklin BH, Fierman AH. Screening obese children and adolescents for prediabetes and/or type 2 diabetes in pediatric practices: a alidation study. Clin Pediatr (Phila) 2014;53:771-776. Epub 2014 Mar 25
Nguyen QM, Srinivasan SR, Xu JH, Chen W, Berenson GS. Fasting plasma glucose levels within the normoglycemic range in childhood as a predictor of prediabetes and type 2 diabetes in adulthood: the Bogalusa Heart Study. Arch Pediatr Adolesc Med 2010;164:124-128.
Nichols GA, Hillier TA, Brown JB. Normal fasting plasma glucose and risk of type 2 diabetes diagnosis. Am J Med 2008;121:519-524.
Tfayli H, Arslanian S. Pathophysiology of type 2 diabetes mellitus in youth: the evolving chameleon. Arq Bras Endocrinol Metabol 2009;53:165-174.
Weiss R, Taksali SE, Tamborlane WV, Burgert TS, Savoye M, Caprio S. Predictors of changes in glucose tolerance status in obese youth. Diabetes Care 2005;28:902-909.
Mc Crindle BW. Cardiovascular Consequences of childhood obesity. Can J Cardiol 2015;31:124-130. Epub 2014 Aug 23
Pires A, Martins P, Pereira AM, Silva PV, Marinho J, Marques M, Castela E, Sena C, Seiça R. Insulin resistance, dyslipidemia and cardiovascular changes in a group of obese children. Arq Bras Cardiol 2015;104:266-273. Epub 2015 Jan 23
Di Bonito P, Capaldo B, Forziato C, Sanguigno E, Di Fraia T, Scilla C, Cavuto L, Saitta F, Sibilio G, Moio N. Central adiposity and left ventricular mass in obese children. Nutr Metab Cardiovasc Dis 2008;18:613-617. Epub 2007 Dec 20
Lee S, Cowan PA, Wetzel GT, Velasquez-Mieyer P. Prediabetes and blood pressure effects on heart rate variability, QT-interval duration, and left ventricular hypertrophy in overweight- obese adolescents. J Pediatr Nurs 2011;26:416-427. Epub 2010 Sep 28
De Marco M, de Simone G, Roman MJ, Chinali M, Lee ET, Calhoun D, Howard BV, Devereux RB. Cardiac geometry and function in diabetic or prediabetic adolescents and young adults: the Strong Heart Study. Diabetes Care 2011;34:2300- 2305. Epub 2011 Aug 26
Simşek E, Balta H, Balta Z, Dallar Y. Childhood obesity- related cardiovascular risk factors and carotid intima-media thickness. Turk J Pediatr 2010;52:602-611
Silva LR, Stefanello JM, Pizzi J, Timossi LS, Leite N. Atherosclerosis subclinical and inflammatory markers in obese and nonobese children and adolescents. Rev Bras Epidemiol 2012;15:804-816.
Stahrenberg R, Edelmann F, Mende M, Kockskämper A, Düngen HD, Scherer M, Kochen MM, Binder L, Herrmann- Lingen C, Schönbrunn L, Gelbrich G, Hasenfuss G, Pieske B, Wachter R. Association of glucose metabolism with diastolic function along the diabetic continuum. Diabetologia 2010;53:1331-1340. Epub 2010 Apr 13
Shah AS, Gao Z, Urbina EM, Kimball TR, Dolan LM. Prediabetes: the effects on arterial thickness and stiffness in obese youth. J Clin Endocrinol Metab 2014;99:1037-1043. Epub 2014 Jan 1
Harada K, Tamura M, Yasuoka K, Toyono M. A comparison oftissue Doppler imaging and velocities of transmitral flow in childrenwith elevated left ventricular preload. Cardiol Young 2001;11:261-268.
Van Putte-Katier N, Rooman RP, Haas L, Verhulst SL, Desager KN, Ramet J, Suys BE. Early cardiac abnormalities in obese children: importance of obesity per se versus associated cardiovascular risk factors. Pediatr Res 2008;64:205-209.

APA	SELVER EKLİOĞLU B, Atabek M, akyurek n, Alp H (2016). Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents. , 80 - 85.
Chicago	SELVER EKLİOĞLU BERAY,Atabek Mehmet Emre,akyurek nesibe,Alp Hayrullah Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents. (2016): 80 - 85.
MLA	SELVER EKLİOĞLU BERAY,Atabek Mehmet Emre,akyurek nesibe,Alp Hayrullah Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents. , 2016, ss.80 - 85.
AMA	SELVER EKLİOĞLU B,Atabek M,akyurek n,Alp H Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents. . 2016; 80 - 85.
Vancouver	SELVER EKLİOĞLU B,Atabek M,akyurek n,Alp H Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents. . 2016; 80 - 85.
IEEE	SELVER EKLİOĞLU B,Atabek M,akyurek n,Alp H "Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents." , ss.80 - 85, 2016.
ISNAD	SELVER EKLİOĞLU, BERAY vd. "Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents". (2016), 80-85.

APA	SELVER EKLİOĞLU B, Atabek M, akyurek n, Alp H (2016). Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents. Journal of Clinical Research in Pediatric Endocrinology, 8(1), 80 - 85.
Chicago	SELVER EKLİOĞLU BERAY,Atabek Mehmet Emre,akyurek nesibe,Alp Hayrullah Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents. Journal of Clinical Research in Pediatric Endocrinology 8, no.1 (2016): 80 - 85.
MLA	SELVER EKLİOĞLU BERAY,Atabek Mehmet Emre,akyurek nesibe,Alp Hayrullah Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents. Journal of Clinical Research in Pediatric Endocrinology, vol.8, no.1, 2016, ss.80 - 85.
AMA	SELVER EKLİOĞLU B,Atabek M,akyurek n,Alp H Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents. Journal of Clinical Research in Pediatric Endocrinology. 2016; 8(1): 80 - 85.
Vancouver	SELVER EKLİOĞLU B,Atabek M,akyurek n,Alp H Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents. Journal of Clinical Research in Pediatric Endocrinology. 2016; 8(1): 80 - 85.
IEEE	SELVER EKLİOĞLU B,Atabek M,akyurek n,Alp H "Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents." Journal of Clinical Research in Pediatric Endocrinology, 8, ss.80 - 85, 2016.
ISNAD	SELVER EKLİOĞLU, BERAY vd. "Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents". Journal of Clinical Research in Pediatric Endocrinology 8/1 (2016), 80-85.