Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report

akyurek, nesibe; SELVER EKLİOĞLU, BERAY; Alp, Hayrullah; Atabek, Mehmet Emre

Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report

Nesibe AKYÜREK, (Necmettin Erbakan Üniversitesi, Tıp Fakültesi, Pediatrik Endokrinoloji ve Diyabet Bölümü, Konya, Türkiye)

Mehmet Emre ATABEK, (Necmettin Erbakan Üniversitesi, Tıp Fakültesi, Pediatrik Endokrinoloji ve Diyabet Bölümü, Konya, Türkiye)

Beray Selver EKLİOĞLU, (Necmettin Erbakan Üniversitesi, Tıp Fakültesi, Pediatrik Endokrinoloji ve Diyabet Bölümü, Konya, Türkiye)

Hayrullah ALP (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Pediatrik Kardiyoloji Bilim Dal, Konya, Türkiye)

Journal of Clinical Research in Pediatric Endocrinology

1 0

Yıl: 2015 Cilt: 7 Sayı: 1 Sayfa Aralığı: 13 - 18 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report

Öz:

Objective: There is an increased risk of cardiovascular morbidity in children and adolescents with classical congenital adrenal hyperplasia (CAH), presumably associated with obesity, hypertension, impaired glucose tolerance and dyslipidemia. This study was designed to evaluate the metabolic and cardiovascular profile of a group of children with classical CAH from the perspective of cardiovascular risk.Methods: Twenty-five CAH patients and 25 healthy controls were included in the study. Metabolic and anthropometric parameters were investigated and compared in these two groups. Results: Subjects in the CAH group were shorter than the controls (p=0.001) and had higher body mass index values (p=0.033). Diastolic blood pressure (DBP) (p=0.027) and carotid intima-media thickness (CIMT) values (p=0.006) were also higher in the patient group. In 24% (n=6) of CAH patients, 24-h ambulatory BP monitoring showed arterial hypertension. CIMT was significantly higher in the hypertensive patients than in those with no hypertension (p=0.013). Twenty percent (n=5) of CAH patients had nocturnal hypertension. CIMT was significantly greater in the nocturnal hypertensive group (p=0.02). Mean systolic BP (SBP) and DBP dipping were significantly different in the CAH patients (p<0.001). CIMT correlated negatively with DBP dipping (r=-0632, p=0.037) in these patients.Conclusion: These results provide additional evidence for the presence of subclinical cardiovascular disease in classical CAH patients and its relationship with hypertension

Anahtar Kelime:

Konular: Endokrinoloji ve Metabolizma Pediatri

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	akyurek n, Atabek M, SELVER EKLİOĞLU B, Alp H (2015). Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report. , 13 - 18.
Chicago	akyurek nesibe,Atabek Mehmet Emre,SELVER EKLİOĞLU BERAY,Alp Hayrullah Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report. (2015): 13 - 18.
MLA	akyurek nesibe,Atabek Mehmet Emre,SELVER EKLİOĞLU BERAY,Alp Hayrullah Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report. , 2015, ss.13 - 18.
AMA	akyurek n,Atabek M,SELVER EKLİOĞLU B,Alp H Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report. . 2015; 13 - 18.
Vancouver	akyurek n,Atabek M,SELVER EKLİOĞLU B,Alp H Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report. . 2015; 13 - 18.
IEEE	akyurek n,Atabek M,SELVER EKLİOĞLU B,Alp H "Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report." , ss.13 - 18, 2015.
ISNAD	akyurek, nesibe vd. "Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report". (2015), 13-18.

APA	akyurek n, Atabek M, SELVER EKLİOĞLU B, Alp H (2015). Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report. Journal of Clinical Research in Pediatric Endocrinology, 7(1), 13 - 18.
Chicago	akyurek nesibe,Atabek Mehmet Emre,SELVER EKLİOĞLU BERAY,Alp Hayrullah Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report. Journal of Clinical Research in Pediatric Endocrinology 7, no.1 (2015): 13 - 18.
MLA	akyurek nesibe,Atabek Mehmet Emre,SELVER EKLİOĞLU BERAY,Alp Hayrullah Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report. Journal of Clinical Research in Pediatric Endocrinology, vol.7, no.1, 2015, ss.13 - 18.
AMA	akyurek n,Atabek M,SELVER EKLİOĞLU B,Alp H Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report. Journal of Clinical Research in Pediatric Endocrinology. 2015; 7(1): 13 - 18.
Vancouver	akyurek n,Atabek M,SELVER EKLİOĞLU B,Alp H Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report. Journal of Clinical Research in Pediatric Endocrinology. 2015; 7(1): 13 - 18.
IEEE	akyurek n,Atabek M,SELVER EKLİOĞLU B,Alp H "Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report." Journal of Clinical Research in Pediatric Endocrinology, 7, ss.13 - 18, 2015.
ISNAD	akyurek, nesibe vd. "Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Patients with Congenital Adrenal Hyperplasia: A Preliminary Report". Journal of Clinical Research in Pediatric Endocrinology 7/1 (2015), 13-18.