KDIGO (Kidney Disease: Improving Global Outcomes) criteria as a predictor of hospital mortality in cirrhotic patients

sayin, serhat; DEMİR, ALİ; biyik, murat; ATASEVEN, Hüseyin; CIFCI, Sami; Biyik, Zeynep; TONBUL, H. Zeki; ASİL, Mehmet

KDIGO (Kidney Disease: Improving Global Outcomes) criteria as a predictor of hospital mortality in cirrhotic patients

Murat BIYIK, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Konya, Türkiye)

Hüseyin ATASEVEN, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Konya, Türkiye)

Zeynep BIYIK, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Konya, Türkiye)

Mehmet ASİL, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Konya, Türkiye)

Sami CIFCI, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Konya, Türkiye)

Serhat SAYIN, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Konya, Türkiye)

H. Zeki TONBUL, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Konya, Türkiye)

Ali DEMİR (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Konya, Türkiye)

Turkish Journal of Gastroenterology

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Yıl: 2016 Cilt: 27 Sayı: 2 Sayfa Aralığı: 173 - 179 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

KDIGO (Kidney Disease: Improving Global Outcomes) criteria as a predictor of hospital mortality in cirrhotic patients

Öz:

Background/Aims: Acute kidney injury (AKI) is frequent in cirrhotic patients and is associated with a poor prognosis. Recently, the Kidney Disease: Improving Global Outcomes (KDIGO) organization recommended new criteria for the diagnosis and staging for AKI. The aim of this study was to evaluate the presence of AKI according to KDIGO criteria in cirrhotic patients admitted to the hospital and to determine its association with hospital mortality.Materials and Methods: This retrospective study included 277 cirrhotic patients admitted to the intensive care unit and gastroenterology service of a tertiary referral hospital from January 2008 to January 2012. AKI was diagnosed and classified according to the KDIGO criteria.Results: The overall incidence of AKI in cirrhotic patients was 39%, and the overall hospital mortality was 15.5%. Patients without AKI had a hospital mortality rate of 2.4%, whereas the mortality rate for patients with AKI was 36.1%. The peak AKI stage detected during hospitalization was stage 1 for 58 patients (53.7%), stage 2 for 20 patients (18.5%), and stage 3 for 30 patients (27.7%). Mortality was found to be associated with the presence, stage, and progression of AKI. Multivariate analysis showed that AKI was an independent factor significantly associated with mortality (odds ratio: 9.1; 95% confidence interval: 2.89-29.1; p<0.001).Conclusion: KDIGO criteria can be used to evaluate AKI in cirrhotic patients. The prevalence of AKI in patients with cirrhosis is high, and AKI is associated with mortality. If early preventive measures are taken, it may be possible to prevent AKI progression and thus mortality

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

Vergara M, Cleries M, Vela E, Bustins M, Miquel M, Campo R. Hospital mortality over time in patients with specific com- plications of cirrhosis. Liver Int 2013; 33: 828-33. [CrossRef]
du Cheyron D, Bouchet B, Parienti JJ, Ramakers M, Charbon- neau P. The attributable mortality of acute renal failure in critically ill patients with liver cirrhosis. Intensive Care Med 2005; 31: 1693-9. [CrossRef]
Moller S, Krag A, Bendtsen F. Kidney injury in cirrhosis: pathophysiological and therapeutic aspects of hepatorenal syndromes. Liver Int 2014; 34: 1153-63. [CrossRef]
Egerod Israelsen M, Gluud LL, Krag A. Acute kidney injury and hepatorenal syndrome in cirrhosis. J Gastroenterol Hep- atol 2015; 30: 236-43. [CrossRef]
Moreau R, Lebrec D. Acute renal failure in patients with cir- rhosis: perspectives in the age of MELD. Hepatology 2003; 37: 233-43. [CrossRef]
Gungor G, Ataseven H, Demir A, et al. Neutrophil gelatinase- associated lipocalin in prediction of mortality in patients with hepatorenal syndrome: a prospective observational study. Liver Int 2014; 34: 49-57. [CrossRef]
Belcher JM, Parikh CR, Garcia-Tsao G. Acute kidney injury in patients with cirrhosis: perils and promise. Clin Gastroen- terol Hepatol 2013; 11: 1550-8. [CrossRef]
Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P. Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Sec- ond International Consensus Conference of the Acute Dialy- sis Quality Initiative (ADQI) Group. Crit Care 2004; 8: R204-12. [CrossRef]
Mehta RL, Kellum JA, Shah SV, et al. Acute Kidney Injury Net- work: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007; 11: R31. [CrossRef]
Lassnigg A, Schmidlin D, Mouhieddine M, et al. Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: a prospective cohort study. J Am Soc Nephrol 2004; 15: 1597-605. [CrossRef]
Newsome BB, Warnock DG, McClellan WM, et al. Long-term risk of mortality and end-stage renal disease among the el- derly after small increases in serum creatinine level during hospitalization for acute myocardial infarction. Arch Intern Med 2008; 168 : 609-16. [CrossRef]
Wong F, Nadim MK, Kellum JA, et al. Working Party proposal for a revised classification system of renal dysfunction in pa- tients with cirrhosis. Gut 2011; 60: 702-9. [CrossRef]
Cholongitas E, Calvaruso V, Senzolo M, et al. RIFLE classifica- tion as predictive factor of mortality in patients with cirrho- sis admitted to intensive care unit. J Gastroenterol Hepatol 2009; 24: 1639-47. [CrossRef]
Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Inter 2012; 2 (Suppl): 1-138.
Selewski DT, Cornell TT, Heung M, et al. Validation of the KDIGO acute kidney injury criteria in a pediatric critical care population. Intensive Care Med 2014; 40: 1481-8. [CrossRef]
Fidalgo P, Ahmed M, Meyer SR, et al. Incidence and out- comes of acute kidney injury following orthotopic lung transplantation: a population-based cohort study. Nephrol Dial Transplant 2014; 29: 1702-9. [CrossRef]
Machado MN, Nakazone MA, Maia LN. Prognostic value of acute kidney injury after cardiac surgery according to kidney disease: improving global outcomes definition and staging (KDIGO) criteria. PLoS One 2014; 9: e98028. [CrossRef]
Peng Q, Zhang L, Ai Y. Epidemiology of acute kidney injury in intensive care septic patients based on the KDIGO guide- lines. Chin Med J (Engl) 2014; 127: 1820-6.
Freeman RB, Jr., Wiesner RH, Harper A, et al. The new liver al- location system: moving toward evidence-based transplan- tation policy. Liver Transpl 2002; 8: 851-8. [CrossRef]
de Carvalho JR, Villela-Nogueira CA, Luiz RR, et al. Acute kid- ney injury network criteria as a predictor of hospital mor- tality in cirrhotic patients with ascites. J Clin Gastroenterol 2012; 46: e21-6. [CrossRef]
Scott RA, Austin AS, Kolhe NV, McIntyre CW, Selby NM. Acute kidney injury is independently associated with death in pa- tients with cirrhosis. Frontline Gastroenterol 2013; 4: 191-7. [CrossRef]
Belcher JM, Garcia-Tsao G, Sanyal AJ, et al. Association of AKI with mortality and complications in hospitalized patients with cirrhosis. Hepatology 2013; 57: 753-62. [CrossRef]
Piano S, Rosi S, Maresio G, et al. Evaluation of the Acute Kid- ney Injury Network criteria in hospitalized patients with cir- rhosis and ascites. J Hepatol 2013; 59: 482-9. [CrossRef]
Fede G, D'Amico G, Arvaniti V, et al. Renal failure and cirrho- sis: a systematic review of mortality and prognosis. J Hepatol 2012; 56: 810-8. [CrossRef]
Cardenas A, Gines P, Uriz J, et al. Renal failure after upper gastrointestinal bleeding in cirrhosis: incidence, clinical course, predictive factors, and short-term prognosis. Hepa- tology 2001; 34 (4 Pt 1): 671-6.[CrossRef]
Fang JT, Tsai MH, Tian YC, et al. Outcome predictors and new score of critically ill cirrhotic patients with acute renal fail- ure. Nephrol Dial Transplant 2008; 23: 1961-9. [CrossRef]
Bagshaw SM, Lapinsky S, Dial S, et al. Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy. Intensive Care Med 2009; 35: 871-81. [CrossRef]
Perdomo Coral G, Alves de Mattos A. Renal impairment after spontaneous bacterial peritonitis: incidence and prognosis. Can J Gastroenterol 2003; 17: 187-90.

APA	biyik m, ATASEVEN H, Biyik Z, ASİL M, CIFCI S, sayin s, TONBUL H, DEMİR A (2016). KDIGO (Kidney Disease: Improving Global Outcomes) criteria as a predictor of hospital mortality in cirrhotic patients. , 173 - 179.
Chicago	biyik murat,ATASEVEN Hüseyin,Biyik Zeynep,ASİL Mehmet,CIFCI Sami,sayin serhat,TONBUL H. Zeki,DEMİR ALİ KDIGO (Kidney Disease: Improving Global Outcomes) criteria as a predictor of hospital mortality in cirrhotic patients. (2016): 173 - 179.
MLA	biyik murat,ATASEVEN Hüseyin,Biyik Zeynep,ASİL Mehmet,CIFCI Sami,sayin serhat,TONBUL H. Zeki,DEMİR ALİ KDIGO (Kidney Disease: Improving Global Outcomes) criteria as a predictor of hospital mortality in cirrhotic patients. , 2016, ss.173 - 179.
AMA	biyik m,ATASEVEN H,Biyik Z,ASİL M,CIFCI S,sayin s,TONBUL H,DEMİR A KDIGO (Kidney Disease: Improving Global Outcomes) criteria as a predictor of hospital mortality in cirrhotic patients. . 2016; 173 - 179.
Vancouver	biyik m,ATASEVEN H,Biyik Z,ASİL M,CIFCI S,sayin s,TONBUL H,DEMİR A KDIGO (Kidney Disease: Improving Global Outcomes) criteria as a predictor of hospital mortality in cirrhotic patients. . 2016; 173 - 179.
IEEE	biyik m,ATASEVEN H,Biyik Z,ASİL M,CIFCI S,sayin s,TONBUL H,DEMİR A "KDIGO (Kidney Disease: Improving Global Outcomes) criteria as a predictor of hospital mortality in cirrhotic patients." , ss.173 - 179, 2016.
ISNAD	biyik, murat vd. "KDIGO (Kidney Disease: Improving Global Outcomes) criteria as a predictor of hospital mortality in cirrhotic patients". (2016), 173-179.

APA	biyik m, ATASEVEN H, Biyik Z, ASİL M, CIFCI S, sayin s, TONBUL H, DEMİR A (2016). KDIGO (Kidney Disease: Improving Global Outcomes) criteria as a predictor of hospital mortality in cirrhotic patients. Turkish Journal of Gastroenterology, 27(2), 173 - 179.
Chicago	biyik murat,ATASEVEN Hüseyin,Biyik Zeynep,ASİL Mehmet,CIFCI Sami,sayin serhat,TONBUL H. Zeki,DEMİR ALİ KDIGO (Kidney Disease: Improving Global Outcomes) criteria as a predictor of hospital mortality in cirrhotic patients. Turkish Journal of Gastroenterology 27, no.2 (2016): 173 - 179.
MLA	biyik murat,ATASEVEN Hüseyin,Biyik Zeynep,ASİL Mehmet,CIFCI Sami,sayin serhat,TONBUL H. Zeki,DEMİR ALİ KDIGO (Kidney Disease: Improving Global Outcomes) criteria as a predictor of hospital mortality in cirrhotic patients. Turkish Journal of Gastroenterology, vol.27, no.2, 2016, ss.173 - 179.
AMA	biyik m,ATASEVEN H,Biyik Z,ASİL M,CIFCI S,sayin s,TONBUL H,DEMİR A KDIGO (Kidney Disease: Improving Global Outcomes) criteria as a predictor of hospital mortality in cirrhotic patients. Turkish Journal of Gastroenterology. 2016; 27(2): 173 - 179.
Vancouver	biyik m,ATASEVEN H,Biyik Z,ASİL M,CIFCI S,sayin s,TONBUL H,DEMİR A KDIGO (Kidney Disease: Improving Global Outcomes) criteria as a predictor of hospital mortality in cirrhotic patients. Turkish Journal of Gastroenterology. 2016; 27(2): 173 - 179.
IEEE	biyik m,ATASEVEN H,Biyik Z,ASİL M,CIFCI S,sayin s,TONBUL H,DEMİR A "KDIGO (Kidney Disease: Improving Global Outcomes) criteria as a predictor of hospital mortality in cirrhotic patients." Turkish Journal of Gastroenterology, 27, ss.173 - 179, 2016.
ISNAD	biyik, murat vd. "KDIGO (Kidney Disease: Improving Global Outcomes) criteria as a predictor of hospital mortality in cirrhotic patients". Turkish Journal of Gastroenterology 27/2 (2016), 173-179.