Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication

Dertli, Ramazan; ASİL, Mehmet

Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication

Mehmet ASİL, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Gastroenteroloji Bölümü, Konya, Türkiye)

Ramazan DERTLİ (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Gastroenteroloji Bölümü, Konya, Türkiye)

İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi

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Yıl: 2016 Cilt: 23 Sayı: 4 Sayfa Aralığı: 409 - 413 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication

Öz:

Amaç: Nötrofil lenfosit oranı birçok hastalıkla ilişkisi gösterilmiş ucuz bir belirteçtir. Biz de bu çalışmada kronik Helicobacter pylori enfeksiyonu olan hastalarda nötrofil lenfosit oranını araştırmayı planladık. Gereç ve Yöntem: Kronik Helicobacter pylori enfeksiyonu olan 286 hasta ve 130 Helicobacter pilori (-) kontrol grubuna ait klinik ve laboratuar verileri retrospektif olarak analiz edildi. Bulgular: Ortalama nötrofil lenfosit oranı Helicobacter pylori (+) grupta 1,98±0,76 ve Helicobacter pylori (-) grupta 1,64±0,44 olup aradaki fark istatistiksel olarak anlamlıydı (p<0,001). Ortalama lökosit ve nötrofil sayıları, Helicobacter pylori (+) grupta sırasıyla 7,28±1,55/?L ve 4,27±1,17 /?L ve Helicobacter pylori (-) grupta sırasıyla 6,90±1,38 /?L ve 3,82±1,04 /?L olarak saptanmış olup her iki grup arasındaki fark gerek ortalama lökosit sayısı açısından (p=0,011) gerek se ortalama nötrofil sayısı açısından (p<0,001) anlamlı bulundu. Her iki grup arasında ortalama lenfosit sayısı, hemoglobin, hematokrit, RDW, trombosit sayısı, MPV, PDW açısından fark yoktu. 253 hastaya Helicobacter pylori eradikasyon tedavisi verilmişti. 76 hastada tedavi sonrası hematolojik veriler mevcuttu. Bu hastaların 45'inde (%59,2) eradikasyon tedavisinin başarılı olduğu (grup 1), 31 hastada (%40,8) ise eradikasyonun başarısız olduğu görüldü. Grup 1 için tedavi öncesi ve sonrası ortalama nötrofil lenfosit oranlarının 1,99±0,75 ve 1.70±0.60 olduğu ve aradaki farkın istatistiksel olarak anlamlı olduğu (p=0,004), grup 2 için ise tedavi öncesi ve sonrası ortalama nötrofil lenfosit oranlarının 1,93±0,59 ve 1.76±0.56 olduğu ve aradaki farkın istatistiksel olarak anlamlı olmadığı görüldü. Sonuç: Kronik Helicobacter pylori enfeksiyonunda nötrofil lenfosit oranı artmıştır. Başarılı eradikasyon tedavisi sonrası artmış nötrofil lenfosit oranı normale döner.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Kronik helicobacter pilori enfeksiyonunda nötrofil lenfosit oranı artmıştır ve başarılı eradikasyon sonrası normale döner

Öz:

Aim: Neutrophil to lymphocyte ratio (NLR) is a useful, low cost marker and it was studied in several diseases. This study was conducted to investigate NLR in chronic Helicobacter pylori infection. Materials and Methods: Clinic and laboratory data of 286 patients with chronic Helicobacter pylori infection and 130 Helicobacter pylori negative controls were analyzed retrospectively. Results: Mean neutrophil to lymphocyte ratio was higher in Helicobacter pylori (+) group than Helicobacter pylori (-) controls (1.98±0.76 vs. 1.64±0.44, p<0.001 respectively) Mean white blood cell and neutrophil counts were also significantly higher in Helicobacter pylori (+) group than Helicobacter pylori (-) controls (7.28±1.55/?L vs. 6.90±1.38 /?L, p=0.011 and 4.27±1.17 /?L vs. 3.82±1.04 /?L, p<0.001 respectively). Lymphocyte count, Hb, Hct, RDW, Plt, MPV, PDW were similar in both groups. 253 patients (88.5%) were given Helicobacter pylori eradication regimen. Post-treatment data were available in 76 (26.6%) patients. Helicobacter pylori, eradication treatment was successful in 45 (59.2%) patients (Group 1) and unsuccessful in 31 (40.8%) patients (Group 2). In group 1, mean pretreatment and post-treatment NLR were 1.99±0.75 and 1.70±0.60 respectively and difference was statistically significant (p=0,004). In group 2 mean pretreatment and post-treatment NLR were 1.93±0.59 and 1.76±0.56 respectively but the difference was not statistically significant (p=0.11). Conclusion: NLR is increased in chronic H.pylori infection and returns to normal after successful H.pylori eradication treatment

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ASİL M, Dertli R (2016). Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication. , 409 - 413.
Chicago	ASİL Mehmet,Dertli Ramazan Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication. (2016): 409 - 413.
MLA	ASİL Mehmet,Dertli Ramazan Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication. , 2016, ss.409 - 413.
AMA	ASİL M,Dertli R Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication. . 2016; 409 - 413.
Vancouver	ASİL M,Dertli R Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication. . 2016; 409 - 413.
IEEE	ASİL M,Dertli R "Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication." , ss.409 - 413, 2016.
ISNAD	ASİL, Mehmet - Dertli, Ramazan. "Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication". (2016), 409-413.

APA	ASİL M, Dertli R (2016). Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, 23(4), 409 - 413.
Chicago	ASİL Mehmet,Dertli Ramazan Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi 23, no.4 (2016): 409 - 413.
MLA	ASİL Mehmet,Dertli Ramazan Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, vol.23, no.4, 2016, ss.409 - 413.
AMA	ASİL M,Dertli R Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi. 2016; 23(4): 409 - 413.
Vancouver	ASİL M,Dertli R Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi. 2016; 23(4): 409 - 413.
IEEE	ASİL M,Dertli R "Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication." İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, 23, ss.409 - 413, 2016.
ISNAD	ASİL, Mehmet - Dertli, Ramazan. "Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication". İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi 23/4 (2016), 409-413.