The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate

ÖZGÖRGÜLÜ, AYDAN; KARABULUT, Yasemin Yuyucu; SAYILMAZ, Aysun

The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate

Aysun SAYILMAZ, (Necmetti ?n Erbakan University Meram School of Medicine, Institute of Health Sciences, Konya, Turkey)

Yasemin Yuyucu KARABULUT, (Department of Pathology, Mersin University School of Medicine, Mersin, Turkey)

Aydan ÖZGÖRGÜLÜ (Necmetti ?n Erbakan University Meram School of Medicine, Institute of Health Sciences, Konya, Turkey)

Turkish Journal of Urology

2 0

Yıl: 2016 Cilt: 42 Sayı: 4 Sayfa Aralığı: 235 - 239 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate

Öz:

Objective: Methotrexate (MTX) leads to acute toxic side effects in tissues or organs containing rapidly dividing cells such as seminiferous tubules. In this study, we investigated the protective effects of vitamin C against MTX-induced injury in rat testis.Material and methods: A total of 31 rats were divided into 4 groups, including the control group. The study was completed within 4 weeks and the rats received daily doses of 2 mL/kg SF, 100 mg/kg vitamin C and 10 mg/kg/day MTX i.p according to their groups. The mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score were determined by histologic examination of each group.Results: The vitamin C + MTX group showed more similarity with the control group. Statistically significant results were achieved between groups as for mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score. When compared with the group which received vitamin C after MTX therapy, values for mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score were significantly higher in the group which received vitamin C before initiation of MTX therapy.Conclusion: Vitamin C decreased MTX-induced testicular histological injuries, especially when used before MTX therapy

Anahtar Kelime:

Konular: Üroloji ve Nefroloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	SAYILMAZ A, KARABULUT Y, ÖZGÖRGÜLÜ A (2016). The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate. , 235 - 239.
Chicago	SAYILMAZ Aysun,KARABULUT Yasemin Yuyucu,ÖZGÖRGÜLÜ AYDAN The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate. (2016): 235 - 239.
MLA	SAYILMAZ Aysun,KARABULUT Yasemin Yuyucu,ÖZGÖRGÜLÜ AYDAN The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate. , 2016, ss.235 - 239.
AMA	SAYILMAZ A,KARABULUT Y,ÖZGÖRGÜLÜ A The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate. . 2016; 235 - 239.
Vancouver	SAYILMAZ A,KARABULUT Y,ÖZGÖRGÜLÜ A The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate. . 2016; 235 - 239.
IEEE	SAYILMAZ A,KARABULUT Y,ÖZGÖRGÜLÜ A "The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate." , ss.235 - 239, 2016.
ISNAD	SAYILMAZ, Aysun vd. "The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate". (2016), 235-239.

APA	SAYILMAZ A, KARABULUT Y, ÖZGÖRGÜLÜ A (2016). The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate. Turkish Journal of Urology, 42(4), 235 - 239.
Chicago	SAYILMAZ Aysun,KARABULUT Yasemin Yuyucu,ÖZGÖRGÜLÜ AYDAN The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate. Turkish Journal of Urology 42, no.4 (2016): 235 - 239.
MLA	SAYILMAZ Aysun,KARABULUT Yasemin Yuyucu,ÖZGÖRGÜLÜ AYDAN The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate. Turkish Journal of Urology, vol.42, no.4, 2016, ss.235 - 239.
AMA	SAYILMAZ A,KARABULUT Y,ÖZGÖRGÜLÜ A The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate. Turkish Journal of Urology. 2016; 42(4): 235 - 239.
Vancouver	SAYILMAZ A,KARABULUT Y,ÖZGÖRGÜLÜ A The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate. Turkish Journal of Urology. 2016; 42(4): 235 - 239.
IEEE	SAYILMAZ A,KARABULUT Y,ÖZGÖRGÜLÜ A "The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate." Turkish Journal of Urology, 42, ss.235 - 239, 2016.
ISNAD	SAYILMAZ, Aysun vd. "The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate". Turkish Journal of Urology 42/4 (2016), 235-239.