Rectal or intramuscular diclofenac reduces the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography

POLAT, İlker; DEMİR, ALİ; CIFCI, Sami; biyik, murat; UÇAR, Ramazan; UÇAR, Esma; ATASEVEN, Hüseyin

Rectal or intramuscular diclofenac reduces the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography

Ramazan UÇAR, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Konya, Türkiye)

Murat BIYIK, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Gastroenteroloji Bölümü, Konya, Türkiye)

Esma UÇAR, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Konya, Türkiye)

İlker POLAT, (Afyonkarahisar Devlet Hastanesi, İç Hastalıkları Anabilim Dalı, Afyonkarahisar, Türkiye)

Sami CIFCI, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Gastroenteroloji Bölümü, Konya, Türkiye)

Hüseyin ATASEVEN, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Gastroenteroloji Bölümü, Konya, Türkiye)

Ali DEMİR (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Gastroenteroloji Bölümü, Konya, Türkiye)

Turkish Journal of Medical Sciences

3 0

Yıl: 2016 Cilt: 46 Sayı: 4 Sayfa Aralığı: 1059 - 1063 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Rectal or intramuscular diclofenac reduces the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography

Öz:

Background/aim: Acute pancreatitis is the most common adverse event of endoscopic retrograde cholangiopancreatography (ERCP). We aimed to evaluate the efficacy of intramuscular diclofenac sodium for prophylaxis of post-ERCP pancreatitis (PEP) in comparison to the rectal form. Materials and methods: One hundred and fifty consecutive patients who underwent ERCP were enrolled in this single-center, prospective, randomized controlled study. Patients were randomized into three groups. The first group received 75 mg of diclofenac sodium via intramuscular route and the second group received 100 mg of diclofenac sodium rectally 30 90 min before the procedure. The third group served as the control group. Patients were evaluated for post-ERCP pancreatitis with serum amylase levels and abdominal pain 24 h after the procedure. Results: The overall incidence of PEP was 6% (n = 9) and 2% (n = 1) in the intramuscular (IM) and rectal groups, respectively, and 14% in the control group (P = 0.014). Nineteen (12.7%) patients developed post-ERCP abdominal pain (8% in IM, 10% in rectal, and 20% in control group; P = 0.154). Twenty-five (16.6%) patients developed post-ERCP hyperamylasemia (10% in IM, 12% in rectal, and 24% in control group; P = 0.03). Conclusion: Prophylaxis with diclofenac given rectally or intramuscularly is an effective option for the management of post-ERCP pancreatitis.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	UÇAR R, biyik m, UÇAR E, POLAT İ, CIFCI S, ATASEVEN H, DEMİR A (2016). Rectal or intramuscular diclofenac reduces the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography. , 1059 - 1063.
Chicago	UÇAR Ramazan,biyik murat,UÇAR Esma,POLAT İlker,CIFCI Sami,ATASEVEN Hüseyin,DEMİR ALİ Rectal or intramuscular diclofenac reduces the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography. (2016): 1059 - 1063.
MLA	UÇAR Ramazan,biyik murat,UÇAR Esma,POLAT İlker,CIFCI Sami,ATASEVEN Hüseyin,DEMİR ALİ Rectal or intramuscular diclofenac reduces the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography. , 2016, ss.1059 - 1063.
AMA	UÇAR R,biyik m,UÇAR E,POLAT İ,CIFCI S,ATASEVEN H,DEMİR A Rectal or intramuscular diclofenac reduces the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography. . 2016; 1059 - 1063.
Vancouver	UÇAR R,biyik m,UÇAR E,POLAT İ,CIFCI S,ATASEVEN H,DEMİR A Rectal or intramuscular diclofenac reduces the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography. . 2016; 1059 - 1063.
IEEE	UÇAR R,biyik m,UÇAR E,POLAT İ,CIFCI S,ATASEVEN H,DEMİR A "Rectal or intramuscular diclofenac reduces the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography." , ss.1059 - 1063, 2016.
ISNAD	UÇAR, Ramazan vd. "Rectal or intramuscular diclofenac reduces the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography". (2016), 1059-1063.

APA	UÇAR R, biyik m, UÇAR E, POLAT İ, CIFCI S, ATASEVEN H, DEMİR A (2016). Rectal or intramuscular diclofenac reduces the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography. Turkish Journal of Medical Sciences, 46(4), 1059 - 1063.
Chicago	UÇAR Ramazan,biyik murat,UÇAR Esma,POLAT İlker,CIFCI Sami,ATASEVEN Hüseyin,DEMİR ALİ Rectal or intramuscular diclofenac reduces the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography. Turkish Journal of Medical Sciences 46, no.4 (2016): 1059 - 1063.
MLA	UÇAR Ramazan,biyik murat,UÇAR Esma,POLAT İlker,CIFCI Sami,ATASEVEN Hüseyin,DEMİR ALİ Rectal or intramuscular diclofenac reduces the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography. Turkish Journal of Medical Sciences, vol.46, no.4, 2016, ss.1059 - 1063.
AMA	UÇAR R,biyik m,UÇAR E,POLAT İ,CIFCI S,ATASEVEN H,DEMİR A Rectal or intramuscular diclofenac reduces the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography. Turkish Journal of Medical Sciences. 2016; 46(4): 1059 - 1063.
Vancouver	UÇAR R,biyik m,UÇAR E,POLAT İ,CIFCI S,ATASEVEN H,DEMİR A Rectal or intramuscular diclofenac reduces the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography. Turkish Journal of Medical Sciences. 2016; 46(4): 1059 - 1063.
IEEE	UÇAR R,biyik m,UÇAR E,POLAT İ,CIFCI S,ATASEVEN H,DEMİR A "Rectal or intramuscular diclofenac reduces the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography." Turkish Journal of Medical Sciences, 46, ss.1059 - 1063, 2016.
ISNAD	UÇAR, Ramazan vd. "Rectal or intramuscular diclofenac reduces the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography". Turkish Journal of Medical Sciences 46/4 (2016), 1059-1063.