Effects of resveratrol and cigarette smoking on bone healing: histomorphometric evaluation

KOLKESEN ŞAHİN, Özge; ÇINA AKSOY, Müge; AVUNDUK, MUSTAFA CIHAT

Effects of resveratrol and cigarette smoking on bone healing: histomorphometric evaluation

Özge KOLKESEN ŞAHİN, (Süleyman Demirel Üniversitesi, Diş Hekimliği Fakültesi Ağız ve Diş Hekimliği Anabilim Dalı, Isparta, Türkiye)

Müge ÇINA AKSOY, (Süleyman Demirel Üniversitesi, Diş Hekimliği Fakültesi Ağız ve Diş Hekimliği Anabilim Dalı, Isparta, Türkiye)

Mustafa Cihat AVUNDUK (Necmettin Erbakan Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı Konya, Türkiye)

Turkish Journal of Medical Sciences

1 0

Yıl: 2016 Cilt: 46 Sayı: 4 Sayfa Aralığı: 1203 - 1208 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Effects of resveratrol and cigarette smoking on bone healing: histomorphometric evaluation

Öz:

Background/aim: The aim of the present study is to investigate the effects of cigarette smoke (CS) and simultaneous application of resveratrol on bone healing histomorphometrically and to evaluate the effects of resveratrol on negative effects of CS. Materials and methods: For 4 weeks, Sprague Dawley rats were exposed to cigarette smoke at the equivalent of 6 cigarettes per day. After this period, monocortical defects were created in femurs by a trephine bur on day 28. Starting from the day of defect creation to the 28th postoperative day, rats were given 20 mg/kg body weight resveratrol. Histomorphometric examination of the number of osteoblasts and osteoclasts, as well as new bone area, was conducted. Results: Investigations were carried out on 33 rats. Differences between osteoblast numbers in the control and CS groups were significant, and CS caused a reduction in the number of osteoblasts. Areas of new bone formation in the resveratrol and control groups were higher than in the smoking and smoking+resveratrol groups. Conclusion: Smoking appeared to have adverse effects upon bone healing and resveratrol administration helped to reduce these effects.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KOLKESEN ŞAHİN Ö, ÇINA AKSOY M, AVUNDUK M (2016). Effects of resveratrol and cigarette smoking on bone healing: histomorphometric evaluation. , 1203 - 1208.
Chicago	KOLKESEN ŞAHİN Özge,ÇINA AKSOY Müge,AVUNDUK MUSTAFA CIHAT Effects of resveratrol and cigarette smoking on bone healing: histomorphometric evaluation. (2016): 1203 - 1208.
MLA	KOLKESEN ŞAHİN Özge,ÇINA AKSOY Müge,AVUNDUK MUSTAFA CIHAT Effects of resveratrol and cigarette smoking on bone healing: histomorphometric evaluation. , 2016, ss.1203 - 1208.
AMA	KOLKESEN ŞAHİN Ö,ÇINA AKSOY M,AVUNDUK M Effects of resveratrol and cigarette smoking on bone healing: histomorphometric evaluation. . 2016; 1203 - 1208.
Vancouver	KOLKESEN ŞAHİN Ö,ÇINA AKSOY M,AVUNDUK M Effects of resveratrol and cigarette smoking on bone healing: histomorphometric evaluation. . 2016; 1203 - 1208.
IEEE	KOLKESEN ŞAHİN Ö,ÇINA AKSOY M,AVUNDUK M "Effects of resveratrol and cigarette smoking on bone healing: histomorphometric evaluation." , ss.1203 - 1208, 2016.
ISNAD	KOLKESEN ŞAHİN, Özge vd. "Effects of resveratrol and cigarette smoking on bone healing: histomorphometric evaluation". (2016), 1203-1208.

APA	KOLKESEN ŞAHİN Ö, ÇINA AKSOY M, AVUNDUK M (2016). Effects of resveratrol and cigarette smoking on bone healing: histomorphometric evaluation. Turkish Journal of Medical Sciences, 46(4), 1203 - 1208.
Chicago	KOLKESEN ŞAHİN Özge,ÇINA AKSOY Müge,AVUNDUK MUSTAFA CIHAT Effects of resveratrol and cigarette smoking on bone healing: histomorphometric evaluation. Turkish Journal of Medical Sciences 46, no.4 (2016): 1203 - 1208.
MLA	KOLKESEN ŞAHİN Özge,ÇINA AKSOY Müge,AVUNDUK MUSTAFA CIHAT Effects of resveratrol and cigarette smoking on bone healing: histomorphometric evaluation. Turkish Journal of Medical Sciences, vol.46, no.4, 2016, ss.1203 - 1208.
AMA	KOLKESEN ŞAHİN Ö,ÇINA AKSOY M,AVUNDUK M Effects of resveratrol and cigarette smoking on bone healing: histomorphometric evaluation. Turkish Journal of Medical Sciences. 2016; 46(4): 1203 - 1208.
Vancouver	KOLKESEN ŞAHİN Ö,ÇINA AKSOY M,AVUNDUK M Effects of resveratrol and cigarette smoking on bone healing: histomorphometric evaluation. Turkish Journal of Medical Sciences. 2016; 46(4): 1203 - 1208.
IEEE	KOLKESEN ŞAHİN Ö,ÇINA AKSOY M,AVUNDUK M "Effects of resveratrol and cigarette smoking on bone healing: histomorphometric evaluation." Turkish Journal of Medical Sciences, 46, ss.1203 - 1208, 2016.
ISNAD	KOLKESEN ŞAHİN, Özge vd. "Effects of resveratrol and cigarette smoking on bone healing: histomorphometric evaluation". Turkish Journal of Medical Sciences 46/4 (2016), 1203-1208.