Differentiated Thyroid Papillary Carcinoma with Cerebellar Metastasis: A Case Report

TURAN, Elif; KAYA, Ahmet; KOZACİOĞLU, Sümeyye; Kulaksizoglu, Mustafa; Zamani, Ayse Gul

Differentiated Thyroid Papillary Carcinoma with Cerebellar Metastasis: A Case Report

Ahmet KAYA, (Necmettin Erbakan University Meram Faculty of, Department of Endocrinology and Metabolic Disease, Konya, Turkey)

Mustafa KULAKSIZOĞLU, (Necmettin Erbakan University Meram Faculty of, Department of Endocrinology and Metabolic Disease, Konya, Turkey)

Ayşe Gül ZAMANİ, (Necmettin Erbakan University Meram Faculty of Medicine, Department of Medical Genetic, Konya, Turkey)

Sümeyye KOZACİOĞLU (Necmettin Erbakan University Meram Faculty of Medicine, Department of Pathology, Konya, Turkey)

Turkish Journal of Endocrinology and Metabolism

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Yıl: 2017 Cilt: 21 Sayı: 1 Sayfa Aralığı: 22 - 25 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Differentiated Thyroid Papillary Carcinoma with Cerebellar Metastasis: A Case Report

Öz:

Diferansiye tiroid kanseri (DTK) genellikle iyi prognozlu ve uzun sureli sağkalıma sahiptir. DTK'nin uzak metastaz oranı 5-15%'dir. Major uzak metastaz alanları akciğer ve kemiklerdir. Serebrum, meme, karaciğer, böbrek, kas ve deri metastazları çok nadirdir. Tiroid papiller karsinomasının (PTK) moleküler mekanizmalarının incelenmesi, BRAFV600E gen mutasyonunun bu hastalık sürecinde önemini ortaya koymuştur. Tiroid papiller kanserlerindeki bu mutasyonlar, ekstratidroidal yayılım, lenf nodu metastazı, tümör rekürrensi ve mortalite ile ilişkilidir. Biz bu olguda akciğer, kemik, karaciğer, adrenal ve serebellar metastazı olan, BRAF mutasyonunun pozitif, PTK'li 55 yaşında erkek hasta sunduk. DTK'de serebrum metaztazı oldukça nadir görülmektedir. Uzak metaztazlar tutulan alana göre farklı semptomlar gösterebilir. Pozitif BRAFV600E gen mutasyonu PTK'li hastalarda agresif seyir açısından fikir verebilir

Anahtar Kelime:

Konular: Endokrinoloji ve Metabolizma

Serebellar Metastazı Olan Diferansiye Tiroid Papiller Karsinom Olgusu

Öz:

Differentiated thyroid cancer (DTC) has usually good prognosis and long-term survival. DTC distant metastasis rate is 5-15%. The major sites of distant metastases are the lung and bone. Metastases to the cerebrum, breast, liver, kidney, muscle, and skin are rare or relatively rare. A study of the molecular mechanisms of papillary thyroid carcinoma (PTC) has demonstrated that the BRAFV600E gene mutation was a significant event in the process of this disease. These mutations in PTC are associated with extrathyroidal spread, lymph node metastasis, tumor recurrence and mortality. We present a 55-year-old male patient with PTC with lung, bone, liver, adrenal and cerebellar metastases, in whom BRAF mutation was positive. Metastasis to cerebrum is rare in DTC. Distant metastasis may show different symptoms, according to the region. Positive BRAFV600E gene mutation may indicate agresiveness of PTC

Anahtar Kelime:

Konular: Endokrinoloji ve Metabolizma

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık

1. Gong RX, Zhou Y, Luo SH, Zhang L, Zhou B. An investigation of BRAF mutation in papillary thyroid carcinoma and its clinical value. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009;26:310-313.
2. Mazzaferri EL, Massoll N. Management of papillary and follicular (differentiated) thyroid cancer: new paradigms using recombinant human thyrotropin. Endocr Relat Cancer. 2002;9:227-247.
3. Pazaıtou-Panayıotou K, Kaprara A, Chrisoulidou A, Boudina M, Georgiou E, Patakiouta F, Drimonitis A, Vainas I. Cerebellar Metastasis as First Metastasis from Papillary Thyroid Carcinoma. Endocr J. 2005;52:653-657.
4. Aguiar PH, Agner C, Tavares FR, Yamaguchi N. Unusual brain metastases from papillary thyroid carcinoma: Case report. Neurosurgery. 2001;49:1008- 1013.
5. Carcangiu ML, Zampi G, Pupi A, Castagnoli A, Rosai J. Papillary carcinoma of the thyroid: a clinicopathologic study of 241 cases treated at the University of Florence, Italy. Cancer. 1985;55:805-828.
6. Tanaka T, Kato N, Aoki K, Nakamura A, Watanabe M, Arai T, Hasecawa Y, Aoki K, Yamamoto K, Abe T. Cerebellar hemorrhage secondary to cerebellopontine angle metastasis from thyroid papillary carcinoma. Neurol Med Chir (Tokyo). 2013;53:233-236.
7. Kim TY, Kim WB, Rhee YS, Song JY, Kim JM, Gong G, Lee S, Kim SY, Kim SC, Hong SJ, Shong YK. The BRAF mutation is useful for prediction of clinical recurrence in low-risk patients with conventional papillary thyroid carcinoma. Clin Endocrinol (Oxf). 2006;65:364-368.
8. American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19:1167-1214.
9. Jonklaas J, Sarlis NJ, Litofsky D, Ain KB, Bigos ST, Brierley JD, Cooper DS, Haugen BR, Ladenson PW, Magner J, Robbins J, Ross DS, Skarulis M, Maxon HR, Sherman SI. Outcomes of patients with differentiated thyroid carcinoma following initial therapy. Thyroid. 2006;16:1229-1242.
10. Pineda JD, Lee T, Ain K, Reynolds JC, Robbins J. Iodine-131 therapy for thyroid cancer patients with elevated thyroglobulin and negative diagnostic scan. J Clin Endocrinol Metab. 1995;80:1488-1492.
11. Sisson JC, Giordano TJ, Jamadar DA, Kazerooni EA, Shapiro B, Gross MD, Zempel SA, Spaulding SA. 131-I treatment of micronodular pulmonary
metastases from papillary thyroid carcinoma. Cancer. 1996;78:2184-2192. 12. Maxon, HR, Smith, HS. Radioiodine-131 in the diagnosis and treatment of metastatic well-differentiated thyroid cancer. Endocrinol Metab Clin North Am. 1990;19:685-718.
13. Maxon HR, Englaro EE, Thomas SR, Hertzberg VS, Hinnefeld JD, Chen LS, Smith H, Cummings D, Aden MD. Radioiodine-131 therapy for welldifferentiated thyroid cancera quantitative radiation dosimetric approach: outcome and validation in 85 patients. J Nucl Med. 1992;33:1132-1136.
14. Lee JW, Koo BS. The prognostic implication and potential role of BRAF mutation inthe decision to perform elective neck dissection for thyroid cancer. Gland Surg. 2013;2:206-211.
15. Lupi C, Giannini R, Ugolini C, Proietti A, Berti P, Minuto M, Materazzi G, Elisei R, Santoro M, Miccoli P, Basolo F. Association of BRAF V600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma. J Clin Endocrinol Metab. 2007;92:4085-4090.
16. Kebebew E, Weng J, Bauer J, Ranvier G, Clark OH, Duh QY, Shibru D, Bastian B, Griffin A. The prevalence and prognostic value of BRAF mutation in thyroid cancer. Ann Surg. 2007;246:466-470; discussion 470-471.
17. Choi SY, Park H, Kang MK, Lee DK, Lee KD, Lee HS, Kim SW, Lee EN, Hong JC. The relationship between the BRAF(V600E) mutation in papillary thyroid microcarcinoma and clinicopathologic factors. World J Surg Oncol. 2013;11:291.

APA	TURAN E, KAYA A, Kulaksizoglu M, Zamani A, KOZACİOĞLU S (2017). Differentiated Thyroid Papillary Carcinoma with Cerebellar Metastasis: A Case Report. , 22 - 25.
Chicago	TURAN Elif,KAYA Ahmet,Kulaksizoglu Mustafa,Zamani Ayse Gul,KOZACİOĞLU Sümeyye Differentiated Thyroid Papillary Carcinoma with Cerebellar Metastasis: A Case Report. (2017): 22 - 25.
MLA	TURAN Elif,KAYA Ahmet,Kulaksizoglu Mustafa,Zamani Ayse Gul,KOZACİOĞLU Sümeyye Differentiated Thyroid Papillary Carcinoma with Cerebellar Metastasis: A Case Report. , 2017, ss.22 - 25.
AMA	TURAN E,KAYA A,Kulaksizoglu M,Zamani A,KOZACİOĞLU S Differentiated Thyroid Papillary Carcinoma with Cerebellar Metastasis: A Case Report. . 2017; 22 - 25.
Vancouver	TURAN E,KAYA A,Kulaksizoglu M,Zamani A,KOZACİOĞLU S Differentiated Thyroid Papillary Carcinoma with Cerebellar Metastasis: A Case Report. . 2017; 22 - 25.
IEEE	TURAN E,KAYA A,Kulaksizoglu M,Zamani A,KOZACİOĞLU S "Differentiated Thyroid Papillary Carcinoma with Cerebellar Metastasis: A Case Report." , ss.22 - 25, 2017.
ISNAD	TURAN, Elif vd. "Differentiated Thyroid Papillary Carcinoma with Cerebellar Metastasis: A Case Report". (2017), 22-25.

APA	TURAN E, KAYA A, Kulaksizoglu M, Zamani A, KOZACİOĞLU S (2017). Differentiated Thyroid Papillary Carcinoma with Cerebellar Metastasis: A Case Report. Turkish Journal of Endocrinology and Metabolism, 21(1), 22 - 25.
Chicago	TURAN Elif,KAYA Ahmet,Kulaksizoglu Mustafa,Zamani Ayse Gul,KOZACİOĞLU Sümeyye Differentiated Thyroid Papillary Carcinoma with Cerebellar Metastasis: A Case Report. Turkish Journal of Endocrinology and Metabolism 21, no.1 (2017): 22 - 25.
MLA	TURAN Elif,KAYA Ahmet,Kulaksizoglu Mustafa,Zamani Ayse Gul,KOZACİOĞLU Sümeyye Differentiated Thyroid Papillary Carcinoma with Cerebellar Metastasis: A Case Report. Turkish Journal of Endocrinology and Metabolism, vol.21, no.1, 2017, ss.22 - 25.
AMA	TURAN E,KAYA A,Kulaksizoglu M,Zamani A,KOZACİOĞLU S Differentiated Thyroid Papillary Carcinoma with Cerebellar Metastasis: A Case Report. Turkish Journal of Endocrinology and Metabolism. 2017; 21(1): 22 - 25.
Vancouver	TURAN E,KAYA A,Kulaksizoglu M,Zamani A,KOZACİOĞLU S Differentiated Thyroid Papillary Carcinoma with Cerebellar Metastasis: A Case Report. Turkish Journal of Endocrinology and Metabolism. 2017; 21(1): 22 - 25.
IEEE	TURAN E,KAYA A,Kulaksizoglu M,Zamani A,KOZACİOĞLU S "Differentiated Thyroid Papillary Carcinoma with Cerebellar Metastasis: A Case Report." Turkish Journal of Endocrinology and Metabolism, 21, ss.22 - 25, 2017.
ISNAD	TURAN, Elif vd. "Differentiated Thyroid Papillary Carcinoma with Cerebellar Metastasis: A Case Report". Turkish Journal of Endocrinology and Metabolism 21/1 (2017), 22-25.