The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model

Ibrahim, Kılınc; DÜNDAR, ZERRİN DEFNE; ÇOLAK, TAMER; oltulu, pembe; Cander, Başar; ergin, mehmet

The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model

Zerrin Defne DÜNDAR, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi Acil Tıp Anabilim Dalı, Konya, Türkiye)

Mehmet ERGİN, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi Acil Tıp Anabilim Dalı, Konya, Türkiye)

İbrahim KILINÇ, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Biyokimya Anabilim Dalı, Konya, Türkiye)

Tamer ÇOLAK, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi Acil Tıp Anabilim Dalı, Konya, Türkiye)

Pembe OLTULU, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Tıbbi Patoloji Anabilim Dalı, Konya, Türkiye)

Başar CANDER (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi Acil Tıp Anabilim Dalı, Konya, Türkiye)

Turkish Journal of Medical Sciences

5 0

Yıl: 2017 Cilt: 47 Sayı: 1 Sayfa Aralığı: 318 - 325 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model

Öz:

Background/aim: This study aimed to evaluate oxidative stress markers of liver tissue in a mouse α-amanitin poisoning model with three different toxin levels. Materials and methods: The mice were randomly divided into Group 1 (control), Group 2 (0.2 mg/kg), Group 3 (0.6 mg/kg), and Group 4 (1.0 mg/kg). The toxin was injected intraperitoneally and 48 h of follow-up was performed before sacrifice. Results: Median superoxide dismutase activities of liver tissue in Groups 3 and 4 were significantly higher than in Group 1 (for both, P = 0.001). The catalase activity in Group 2 was significantly higher, but in Groups 3 and 4 it was significantly lower than in Group 1 (for all, P = 0.001). The glutathione peroxidase activities in Groups 2, 3, and 4 were significantly higher than in Group 1 (P = 0.006, P = 0.001, and P = 0.001, respectively). The malondialdehyde levels of Groups 3 and 4 were significantly higher than Group 1 (P = 0.015 and P = 0.003, respectively). The catalase activity had significant correlations with total antioxidant status and total oxidant status levels (r = 0.935 and r = 0.789, respectively; for both, P < 0.001). Conclusion: Our findings support a significant role for increased oxidative stress in α-amanitin-induced hepatotoxicity.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	DÜNDAR Z, ergin m, Ibrahim K, ÇOLAK T, oltulu p, Cander B (2017). The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model. , 318 - 325.
Chicago	DÜNDAR ZERRİN DEFNE,ergin mehmet,Ibrahim Kılınc,ÇOLAK TAMER,oltulu pembe,Cander Başar The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model. (2017): 318 - 325.
MLA	DÜNDAR ZERRİN DEFNE,ergin mehmet,Ibrahim Kılınc,ÇOLAK TAMER,oltulu pembe,Cander Başar The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model. , 2017, ss.318 - 325.
AMA	DÜNDAR Z,ergin m,Ibrahim K,ÇOLAK T,oltulu p,Cander B The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model. . 2017; 318 - 325.
Vancouver	DÜNDAR Z,ergin m,Ibrahim K,ÇOLAK T,oltulu p,Cander B The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model. . 2017; 318 - 325.
IEEE	DÜNDAR Z,ergin m,Ibrahim K,ÇOLAK T,oltulu p,Cander B "The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model." , ss.318 - 325, 2017.
ISNAD	DÜNDAR, ZERRİN DEFNE vd. "The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model". (2017), 318-325.

APA	DÜNDAR Z, ergin m, Ibrahim K, ÇOLAK T, oltulu p, Cander B (2017). The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model. Turkish Journal of Medical Sciences, 47(1), 318 - 325.
Chicago	DÜNDAR ZERRİN DEFNE,ergin mehmet,Ibrahim Kılınc,ÇOLAK TAMER,oltulu pembe,Cander Başar The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model. Turkish Journal of Medical Sciences 47, no.1 (2017): 318 - 325.
MLA	DÜNDAR ZERRİN DEFNE,ergin mehmet,Ibrahim Kılınc,ÇOLAK TAMER,oltulu pembe,Cander Başar The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model. Turkish Journal of Medical Sciences, vol.47, no.1, 2017, ss.318 - 325.
AMA	DÜNDAR Z,ergin m,Ibrahim K,ÇOLAK T,oltulu p,Cander B The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model. Turkish Journal of Medical Sciences. 2017; 47(1): 318 - 325.
Vancouver	DÜNDAR Z,ergin m,Ibrahim K,ÇOLAK T,oltulu p,Cander B The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model. Turkish Journal of Medical Sciences. 2017; 47(1): 318 - 325.
IEEE	DÜNDAR Z,ergin m,Ibrahim K,ÇOLAK T,oltulu p,Cander B "The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model." Turkish Journal of Medical Sciences, 47, ss.318 - 325, 2017.
ISNAD	DÜNDAR, ZERRİN DEFNE vd. "The role of oxidative stress in α-amanitin-induced hepatotoxicity in an experimental mouse model". Turkish Journal of Medical Sciences 47/1 (2017), 318-325.