Yıl: 2018 Cilt: 28 Sayı: 1 Sayfa Aralığı: 7 - 12 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?

Öz:
AIm: To evaluate and compare the expression of thioredoxin reductase 1 (TrxR1) in primary and secondary glioblastoma samples. mATERIAl and mEThODS: Surgically resected human glioblastoma samples from 40 patients who underwent surgery at our institution were extracted from their histopathological specimens and divided into three groups. Ten histopathologically regular cerebral tissue samples, acquired from the non-neoplastic portion of the specimens, were assigned as the control group. Twenty specimens that included tumoral tissue from each type of glioblastoma (WHO grade IV, primary and secondary) were assigned as the primary and secondary glioblastoma groups. TrxR1 expression was analyzed by using both quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunohistochemistry. Isocitrate dehydrogenase 1 (IDH1) mutation was analyzed by immunohistochemistry. Ki-67 proliferative index and apoptosis were also analyzed by immunohistochemistry. The differences between the groups were statistically compared and the correlation between these parameters was analyzed. RESulTS: The expressions of TrxR1 and Ki-67 values were significantly higher in primary glioblastoma. IDH1 mutation was significantly higher in secondary glioblastoma. TrxR1 expression was found to be highly correlated with the Ki-67 index. The apoptotic index was similar between primary and secondary glioblastoma. CONCluSION: This study showed a high TrxR1 expression in primary glioblastoma which could indicate a role of the Trx system in promoting the malignant progression by some complex processes.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ERDİ F, kaya b, ESEN H, Karatas Y, FINDIK S, keskin f, FEYZİOĞLU B, KALKAN E (2018). New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?. , 7 - 12.
Chicago ERDİ Fatih,kaya bülent,ESEN Hasan,Karatas Yasar,FINDIK Sıddıka,keskin fatih,FEYZİOĞLU Bahadır,KALKAN Erdal New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?. (2018): 7 - 12.
MLA ERDİ Fatih,kaya bülent,ESEN Hasan,Karatas Yasar,FINDIK Sıddıka,keskin fatih,FEYZİOĞLU Bahadır,KALKAN Erdal New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?. , 2018, ss.7 - 12.
AMA ERDİ F,kaya b,ESEN H,Karatas Y,FINDIK S,keskin f,FEYZİOĞLU B,KALKAN E New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?. . 2018; 7 - 12.
Vancouver ERDİ F,kaya b,ESEN H,Karatas Y,FINDIK S,keskin f,FEYZİOĞLU B,KALKAN E New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?. . 2018; 7 - 12.
IEEE ERDİ F,kaya b,ESEN H,Karatas Y,FINDIK S,keskin f,FEYZİOĞLU B,KALKAN E "New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?." , ss.7 - 12, 2018.
ISNAD ERDİ, Fatih vd. "New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?". (2018), 7-12.
APA ERDİ F, kaya b, ESEN H, Karatas Y, FINDIK S, keskin f, FEYZİOĞLU B, KALKAN E (2018). New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?. Turkish Neurosurgery, 28(1), 7 - 12.
Chicago ERDİ Fatih,kaya bülent,ESEN Hasan,Karatas Yasar,FINDIK Sıddıka,keskin fatih,FEYZİOĞLU Bahadır,KALKAN Erdal New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?. Turkish Neurosurgery 28, no.1 (2018): 7 - 12.
MLA ERDİ Fatih,kaya bülent,ESEN Hasan,Karatas Yasar,FINDIK Sıddıka,keskin fatih,FEYZİOĞLU Bahadır,KALKAN Erdal New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?. Turkish Neurosurgery, vol.28, no.1, 2018, ss.7 - 12.
AMA ERDİ F,kaya b,ESEN H,Karatas Y,FINDIK S,keskin f,FEYZİOĞLU B,KALKAN E New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?. Turkish Neurosurgery. 2018; 28(1): 7 - 12.
Vancouver ERDİ F,kaya b,ESEN H,Karatas Y,FINDIK S,keskin f,FEYZİOĞLU B,KALKAN E New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?. Turkish Neurosurgery. 2018; 28(1): 7 - 12.
IEEE ERDİ F,kaya b,ESEN H,Karatas Y,FINDIK S,keskin f,FEYZİOĞLU B,KALKAN E "New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?." Turkish Neurosurgery, 28, ss.7 - 12, 2018.
ISNAD ERDİ, Fatih vd. "New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?". Turkish Neurosurgery 28/1 (2018), 7-12.