Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study
Yıl: 2017 Cilt: 13 Sayı: 1 Sayfa Aralığı: 5 - 9 Metin Dili: İngilizce DOI: 10.5152/tjbh.2016.3142 İndeks Tarihi: 29-03-2019
Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study
Öz: Objective: Breast carcinoma is the most common malignant tumor detected in women. fte hypothesis that increased levels of adhesion molecules and Cathepsin D affect cancerous cells moving away the primary tumor and contributes to migration of the cancerous cell and may cause remote organ metastases is defended. fte aim of the present study was to search the association of intracellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), Cyclin D1, cathepsin D immunohistochemically with clinicopathological parameters in the patients diagnosed with invasive ductal breast carcinoma.Materials and Methods: fte pathological slides of 153 patients diagnosed with invasive ductal carcinoma were evaluated retrospectively. ftree groups were created. Group 1 consisted of patients with positive lymph node metastasis and extranodal tumor invasion; Group 2 consisted of patients with positive axillary lymph node metastasis and negative extranodal tumor invasion and Group 3 consisted of the patients with negative axillary lymph node metastasis. In all groups, 20 paraffin blocks belonging to the primary tumor in the breast were stained by ICAM-1, VCAM-1, Cyclin D1 and Cathepsin D. Findings were examined by comparing with clinicopathological parameters.Results: fte highest number of metastatic axillary lymph nodes and the highest rate of cathepsin D staining were statistically found in the cases with positive axillary lymph node metastasis and extranodal tumor invasion. CerbB2 was negative in the cases with negative ICAM-1 whereas estro- gen receptor and progesterone receptor were positive in the cases with positive VCAM-1.Conclusion: fte present study reveals significant results for the patients diagnosed with invasive ductal carcinoma through breast biopsy espe- cially before mastectomy in terms of increased number of metastatic axillary lymph nodes and extranodal tumor invasion by immunohistochemical Cathepsin D stain without any additional invasive intervention. Results of the present study may contribute to monitoring and treatment of the patients in the future.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Greenlee RT, Murray T, Bolden S, Wingo PA. Cancer Statistics, 2000. CA Cancer J Clin 2000; 50:7-33. (PMID: 10735013) [CrossRef]
- Gillett C, Fantl V, Smith R, Fisher C, Bartek J, Dickson C, Barnes D, Peters G. Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining. Cancer Res 1994; 54:1812- 1817. (PMID: 8137296)
- Velikova G, Banks RE, Gearing A, Hemingway I, Forbes MA, Preston SR, Jones M, Wyatt J, Miller K, Ward U, Al-Maskatti J, Singh SM, Am- brose NS, Primrose JN, Selby PJ. Circulating soluble adhesion molecules E-cadherin, E-selectin, intracellular adhesion molecule-1 (ICAM-1) and vasculer cell adhesion molecule-1 (VCAM-1) in patiens vith gastric can- cer. Br J Cancer 1997; 76:1398-1404. (PMID: 9400933) [CrossRef]
- Fantl V, Richards MA, Smith R, Lammie GA, Johnstone G, Allen D, Gregory W, Peters G, Dickson C, Barnes DM. Gene amplification on chromosome band 11q13 and estrogen receptor status in breast cancer. Eur J Cancer 1990; 26:423-429. (PMID: 2141507) [CrossRef]
- Arnold A, Papanikolaou A. Cyclin D1 in breast cancer pathogenesis. J Clin Oncol 2005; 23:4215-4224. (PMID: 15961768) [CrossRef]
- Ferrandina G, Scambia G, Bardelli F, Benedetti Panici P, Mancuso S, Mes- sori A.Relationship between cathepsin D content and disease-free sur- vival in node-negative breast cancer patients: a meta-analysis. Br J Cancer 1997; 76:661-666. (PMID: 9303368) [CrossRef]
- Rochefort H. Biological and clinical significance of cathepsin D in breast cancer. Acta Oncol. 1992; 31:125-130. (PMID: 1622626) [CrossRef]
- Yusufu M, Changwen W, Munire M, Jie T, Bangxing H, Jing Z, Tao H. Overexpression of VCAM-1 is correlated with poor survival of patients with breast cancer. Int J Clin Exp Pathol 2016; 9:7451-7457.
- Yılmaz G, Geyik P, Uluoğlu Ö, Prognostic significance of immunohis- tochemical expression of cathepsin D, cyclin D1 and thymidine kinase 1 in invasive ductal breast carcinomas with a predominant intraductal component. Gazi Medical Journal 2008; 19:112-120.
- Onitilo AA, Engel JM, Greenlee RT, Mukesh BN. Breast cancer subtypes based on ER/PR and Her2 expression: comparison of clinicopathologic features and survival. Clin Med Res 2009; 7:4-13. (PMID: 19574486) [CrossRef]
- Charpin C, Garcia S, Andrac L, Horschowski N, Choux R, Lavaut MN. VCAM(IGSF) Adhesion Molecule Expression in Breast Carcinomas De- tected by Automated and Quantitative Immunocytochemical Assays. Hum Pathol 1998; 29:896-903. (PMID: 9744304) [CrossRef] Henry JA, McCarthy AL, Angus B, Westley BR, May FE, Nicholson S, Cairns J, Harris AL Horne CH. Prognostic significance of the estrogen regulated protein, cathepsin D, in breast cancer. An immunohistochemi- cal study. Cancer 1990; 65:265-271. (PMID: 2295049) [CrossRef]
- Duffy MJ, Brouillet JP, Reilly D, McDermott E, O’Higgins N, Fennelly JJ, Maudelonde T, Rochefort H. Cathepsin D concentration in breast cancer cytosols: correlation with biochemical, histological and clinical findings. Clin Chem 1991; 37:101-104. (PMID: 1899058)
- Têtu B, Brisson J, Wang CS, Lapointe H, Beaudry G, Blanchette C Ex- pression of cathepsin D, stromelysin-3, and urokinase by reactive stro- mal cells on breast carcinoma prognosis. Cancer 2001; 92:2957-2964. (PMID: 11753972) [CrossRef]
- Fisher BJ, Perera FE, Cooke AL, Opeitum A, Dar AR, Venkatesan VM, Stitt L, Radwan JS. Extracapsular axillary node extension in patients receiving adjuvant systemic therapy: an indication for radiotherapy? Int J Radiat Oncol Biol Phys 1997; 38:551-559. (PMID: 9231679) [CrossRef ]
- Jacobson-Raber G, Lazarev I, Novack V, Mermershteın W, Baumfeld Y, Geffen DB, Sion-Vardy N, Ariad S. fte prognostic importance of cathep- sin D and E-cadherin in early breast cancer: A single-institution experi- ence, Oncol Lett 2011; 2:1183-1190. (PMID: 22848286)
- Dian D, Vrekoussis T, Shabani N, Mylonas I, Kuhn C, Schindlbeck C, Navrozoglou I, Friese K, Makrigiannakis A, Jeschke U. Expression of cathepsin-D in primary breast cancer and corresponding local recurrence or metastasis: an immunohistochemical study. Anticancer Research 2012; 32:901-906. (PMID: 22399610)
- Markićević M, Kanjer K, Mandušić V, Buta M, Nešković-Konstantinović Z, Nikolić-Vukosavljević D.Cathepsin D as an indicator of clinical out- come in early breast carcinoma during the first 3 years of follow-up. Bio- mark Med 2013; 7:747-758. (PMID: 24044567) [CrossRef]
- Huang L, Liu Z, Chen S, Liu Y, Shao Z. A prognostic model for triple- negative breast cancer patients based on node status, cathepsin-D and Ki-67 index. PLoS One 2013; 8:12. (PMID: 24340082) [CrossRef]
- Guerra E, Cimadamore A, Simeone P, Vacca G, Lattanzio R, Botti G, Gatta V, D’Aurora M, Simionati B, Piantelli M, Alberti S. p53, cathepsin D, Bcl-2 are joint prognostic indicators of breast cancer metastatic spread- ing. BMC Cancer 2016; 16:649. (PMID: 27538498)[CrossRef]
| APA | KÜLAHCI Ö, ESEN H, ASUT E, GÜNGÖR S (2017). Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study. , 5 - 9. 10.5152/tjbh.2016.3142 |
| Chicago | KÜLAHCI ÖZGÜR,ESEN H. Hasan,ASUT Elife,GÜNGÖR Salim Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study. (2017): 5 - 9. 10.5152/tjbh.2016.3142 |
| MLA | KÜLAHCI ÖZGÜR,ESEN H. Hasan,ASUT Elife,GÜNGÖR Salim Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study. , 2017, ss.5 - 9. 10.5152/tjbh.2016.3142 |
| AMA | KÜLAHCI Ö,ESEN H,ASUT E,GÜNGÖR S Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study. . 2017; 5 - 9. 10.5152/tjbh.2016.3142 |
| Vancouver | KÜLAHCI Ö,ESEN H,ASUT E,GÜNGÖR S Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study. . 2017; 5 - 9. 10.5152/tjbh.2016.3142 |
| IEEE | KÜLAHCI Ö,ESEN H,ASUT E,GÜNGÖR S "Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study." , ss.5 - 9, 2017. 10.5152/tjbh.2016.3142 |
| ISNAD | KÜLAHCI, ÖZGÜR vd. "Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study". (2017), 5-9. https://doi.org/10.5152/tjbh.2016.3142 |
| APA | KÜLAHCI Ö, ESEN H, ASUT E, GÜNGÖR S (2017). Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study. The Journal of Breast Health, 13(1), 5 - 9. 10.5152/tjbh.2016.3142 |
| Chicago | KÜLAHCI ÖZGÜR,ESEN H. Hasan,ASUT Elife,GÜNGÖR Salim Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study. The Journal of Breast Health 13, no.1 (2017): 5 - 9. 10.5152/tjbh.2016.3142 |
| MLA | KÜLAHCI ÖZGÜR,ESEN H. Hasan,ASUT Elife,GÜNGÖR Salim Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study. The Journal of Breast Health, vol.13, no.1, 2017, ss.5 - 9. 10.5152/tjbh.2016.3142 |
| AMA | KÜLAHCI Ö,ESEN H,ASUT E,GÜNGÖR S Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study. The Journal of Breast Health. 2017; 13(1): 5 - 9. 10.5152/tjbh.2016.3142 |
| Vancouver | KÜLAHCI Ö,ESEN H,ASUT E,GÜNGÖR S Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study. The Journal of Breast Health. 2017; 13(1): 5 - 9. 10.5152/tjbh.2016.3142 |
| IEEE | KÜLAHCI Ö,ESEN H,ASUT E,GÜNGÖR S "Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study." The Journal of Breast Health, 13, ss.5 - 9, 2017. 10.5152/tjbh.2016.3142 |
| ISNAD | KÜLAHCI, ÖZGÜR vd. "Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study". The Journal of Breast Health 13/1 (2017), 5-9. https://doi.org/10.5152/tjbh.2016.3142 |
