Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer
Yıl: 2018 Cilt: 43 Sayı: 2 Sayfa Aralığı: 159 - 166 Metin Dili: İngilizce DOI: 10.1515/tjb-2017-0215 İndeks Tarihi: 04-10-2019
Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer
Öz: Objective: Chemoradiotherapy (CRT) is a commonly usedtherapeutic modality. We investigated CRT effects onacute phase reactants (APRs). The aim of this study wasto assess possible changes in APR levels during radiotherapyand to determine the usefulness of APRs as prognosticfactors in patients with non-small cell lung cancer(NSCLC) and glioblastoma multiforme (GBM).Methods: We prospectively evaluated 30 patients and30 healthy controls. Plasma levels of APRs were measured.Post-CRT and pre-CRT levels were compared. Survival ofpatients were also followed up for a period of 3 years.Results: In NSCLC patients, post-CRT albumin, transferrin(Trf), and ceruloplasmin (Cp) levels were significantlylower, and post-CRT ferritin (FER) levels were significantlyhigher, than their pre-CRT levels. In GBM patients, post-CRT Trf and prealbumin (Prealb) levels were significantlyhigher than pre-CRT levels. Pre-CRT C-reactive protein(CRP) and FER levels in NSCLC patients and Cp levels inGBM patients were associated with patient survival.Conclusion: This study suggests that APRs may be usefulfor monitoring response to treatment during CRT in NSCLCand GBM patients. Bearing in mind their accessibility andclinical value, plasma CRP and FER in NSCLC patients andCp in GBM patients can be considered candidate prognosticfactors.
Anahtar Kelime: Konular:
Glioblastoma multiforme ve lokal ileri evre küçük hücreli dışı akciğer kanserinde kemoradyoterapinin akut faz protein seviyelerine etkisi
Öz: Amaç: Kemoradyoterapi (KRT) sık kullanılan bir tedavi yöntemidir. KRT’nin akut faz reaktanları (AFR) üzerindeki etkilerini araştırdık. Bu çalışmanın amacı, radyoterapi sırasında AFR düzeylerindeki olası değişiklikleri değerlendirmek ve küçük hücreli dışı akciğer kanseri (KHDAK) ve glioblastoma multiforme (GBM) hastalarında prognostik faktör olarak AFR’lerin kullanılabilirliğini belirlemektir. Metod: Prospektif olarak 30 hasta ve 30 sağlıklı kontrol değerlendirildi. AFR’lerin plazma seviyeleri ölçüldü. Post- KRT ve pre-KRT seviyeleri karşılaştırıldı. Hastaların sağkalımı da 3 yıllık bir süre boyunca takip edildi. Bulgular: KHDAK hastalarında; pre-KRT seviyeleri ile karşılaştırıldığında post-KRT albümin, transferrin (Trf), ve seruloplasmin (Cp) düzeyleri anlamlı derecede düşük ve post-KRT ferritin (FER) düzeyleri anlamlı derecede yüksek bulunmuşdur. GBM hastalarında; Post-KRT Trf ve prealbümin (Prealb) düzeyleri KRT öncesi düzeyler ile kıyaslandığında anlamlı derecede yüksekti. KHDAK hastalarında pre-KRT C-reaktif protein (CRP) ve FER düzeyleri ve GBM hastalarında Cp düzeyleri hasta sağkalımı ile ilişkilendirildi. Sonuç: Bu çalışma, AFR’larının KHDAK ve GBM’li hastalarda KRT sırasında tedaviye yanıtın izlenmesi için yararlı olabileceğini düşündürmektedir. Erişilebilirlik ve klinik değeri göz önüne alındığında, KHDAK hastalarında plazma CRP ve FER, GBM hastalarında Cp aday prognostik faktörler olarak düşünülebilir.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010;60:277–300.
- 2. Auperin A, Le Pechoux C, Rolland E, Curran WJ, Furuse K, Fournel P, et al. Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer. J Clin Oncol 2010;28:2181–90.
- 3. O’Rourke N, Roque IF, Farre Bernado N, Macbeth F. Concurrent chemoradiotherapy in non-small cell lung cancer. Cochrane Database Syst Rev 2010;6:CD002140.
- 4. Rosenblum MK. The 2007 WHO Classification of Nervous System Tumors: newly recognized members of the mixed glioneuronal group. Brain Pathol 2007;17:308–13.
- 5. Lu H, Ouyang W, Huang C. Inflammation, a key event in cancer development. Mol Cancer Res 2006;4:221–33.
- 6. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987–96.
- 7. Wigmore SJ, McMahon AJ, Sturgeon CM, Fearon KC. Acute-phase protein response, survival and tumour recurrence in patients with colorectal cancer. Br J Surg 2001;88:255–60.
- 8. van Leeuwen MA, van Rijswijk MH. Acute phase proteins in the monitoring of inflammatory disorders. Baillieres Clin Rheumatol 1994;8:531–52.
- 9. Alkhateeb AA, Han B, Connor JR. Ferritin stimulates breast cancer cells through an iron-independent mechanism and is localized within tumor-associated macrophages. Breast Cancer Res Treat 2013;137:733–44.
- 10. Fracchia A, Ubbiali A, El Bitar O, Pacetti M, Sommariva E, Arreghini M, et al. A comparative study on ferritin concentration in serum and bilateral bronchoalveolar lavage fluid of patients with peripheral lung cancer versus control subjects. Oncology 1999;56:181–8.
- 11. Kukulj S, Jaganjac M, Boranic M, Krizanac S, Santic Z, Poljak- Blazi M. Altered iron metabolism, inflammation, transferrin receptors, and ferritin expression in non-small-cell lung cancer. Med Oncol 2010;27:268–77.
- 12. Arner E, Forrest AR, Ehrlund A, Mejhert N, Itoh M, Kawaji H, et al. Ceruloplasmin is a novel adipokine which is overexpressed in adipose tissue of obese subjects and in obesity-associated cancer cells. PLoS One 2014;9:e80274.
- 13. Cogalgil S, Taysi S. Levels of antioxidant proteins and soluble intercellular adhesion molecule-1 in serum of patients with rheumatoid arthritis. Ann Clin Lab Sci 2002;32:264–70.
- 14. Taysi S, Akcay F, Uslu C, Dogru Y, Gulcin I. Trace elements and some extracellular antioxidant protein levels in serum of patients with laryngeal cancer. Biol Trace Elem Res 2003;9:11–8.
- 15. Orhan HG, Ozgunes H, Beksac MS. Correlation between plasma malondialdehyde and ceruloplasmin activity values in preeclamptic pregnancies. Clin Biochem 2001;34:505–6.
- 16. Taysi S, Polat F, Gul M, Sari RA, Bakan E. Lipid peroxidation, some extracellular antioxidants, and antioxidant enzymes in serum of patients with rheumatoid arthritis. Rheumatol Int 2002;21:200–4.
- 17. Taysi S, Gul M, Sari RA, Akcay F, Bakan N. Serum oxidant/antioxidant status of patients with systemic lupus erythematosus. Clin Chem Lab Med 2002;40:684–8.
- 18. Maria TG, Vasileios KE, Panagiotis PS, Kostas SN. Changes of acute-phase protein levels in the serum of lung cancer patients following radiotherapy. Int J Clin Exp Med 2013;6:50–6.
- 19. Ingenbleek Y, Young VR. Significance of transthyretin in protein metabolism. Clin Chem Lab Med 2002;40:1281–91.
- 20. Koc M, Taysi S, Sezen O, Bakan N. Levels of some acute-phase proteins in the serum of patients with cancer during radiotherapy. Biol Pharm Bull 2003;26:1494–7.
- 21. Han S, Huang Y, Li Z, Hou H, Wu A. The prognostic role of preoperative serum albumin levels in glioblastoma patients. BMC Cancer 2015;15:108.
- 22. Unal D, Orhan O, Eroglu C, Kaplan B. Prealbumin is a more sensitive marker than albumin to assess the nutritional status in patients undergoing radiotherapy for head and neck cancer. Contemp Oncol (Pozn) 2013;17:276–80.
- 23. Maretty-Nielsen K. Prognostic factors in soft tissue sarcoma. Dan Med J 2014;61:B4957.
- 24. Arruda LF, Arruda SF, Campos NA, de Valencia FF, Siqueira EM. Dietary iron concentration may influence aging process by altering oxidative stress in tissues of adult rats. PLoS One 2013;8:e61058.
- 25. Kim KU, Xiao J, Ni HT, Cho KH, Spellman SR, Low WC, et al. Changes in expression of transferrin, insulin-like growth factor 1, and interleukin 4 receptors after irradiation of cells of primary malignant brain tumor cell lines. Radiat Res 2003;160:224–31.
- 26. Orino K, Lehman L, Tsuji Y, Ayaki H, Torti SV, Torti FM. Ferritin and the response to oxidative stress. Biochem J 2001;357(Pt 1):241–7.
- 27. Shi HB, Li XD, Jiang JT, Zhao WQ, Ji M, Wu CP. Serum ferritin is elevated in advanced non-small cell lung cancer patients and is associated with efficacy of platinum-based chemotherapy. J Cancer Res Ther 2014;10:681–5.
- 28. Milman N, Pedersen LM. The serum ferritin concentration is a significant prognostic indicator of survival in primary lung cancer. Oncol Rep 2002;9:193–8.
- 29. Onizuka K, Migita S, Yamada H, Matsumoto I. Serum protein fractions in patients with laryngeal cancer undergoing radiation therapy. Possibility as a prognostic factor. Fukuoka Igaku Zasshi 1999;90:46–58.
- 30. Ozyilkan O, Baltali E, Kirazli S. CA 15-3, ceruloplasmin and tissue polypeptide specific antigen as a tumour marker panel in breast cancer. East Afr Med J 2000;77:291–4.
- 31. Tang LQ, Hu DP, Chen QY, Zhang L, Lai XP, He Y, et al. Elevated high-sensitivity C-reactive protein levels predict decreased survival for nasopharyngeal carcinoma patients in the intensitymodulated radiotherapy era. PLoS One 2015;10:e0122965.
- 32. Zeng YC, Wu R, Xiao YP, Chi F, Xue M, Zhang ZY, et al. Serum C-reactive protein predicts poor prognosis in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy. Curr Oncol 2015;22:20–4.
- 33. Fiala O, Pesek M, Finek J, Topolcan O, Racek J, Minarik M, et al. High serum level of C-reactive protein is associated with worse outcome of patients with advanced-stage NSCLC treated with erlotinib. Tumour Biol 2015;36:9215–22.
| APA | deniz c, GÜRBİLEK M, KOC M (2018). Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer. , 159 - 166. 10.1515/tjb-2017-0215 |
| Chicago | deniz cigdem damla,GÜRBİLEK Mehmet,KOC Mehmet Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer. (2018): 159 - 166. 10.1515/tjb-2017-0215 |
| MLA | deniz cigdem damla,GÜRBİLEK Mehmet,KOC Mehmet Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer. , 2018, ss.159 - 166. 10.1515/tjb-2017-0215 |
| AMA | deniz c,GÜRBİLEK M,KOC M Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer. . 2018; 159 - 166. 10.1515/tjb-2017-0215 |
| Vancouver | deniz c,GÜRBİLEK M,KOC M Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer. . 2018; 159 - 166. 10.1515/tjb-2017-0215 |
| IEEE | deniz c,GÜRBİLEK M,KOC M "Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer." , ss.159 - 166, 2018. 10.1515/tjb-2017-0215 |
| ISNAD | deniz, cigdem damla vd. "Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer". (2018), 159-166. https://doi.org/10.1515/tjb-2017-0215 |
| APA | deniz c, GÜRBİLEK M, KOC M (2018). Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer. Türk Biyokimya Dergisi, 43(2), 159 - 166. 10.1515/tjb-2017-0215 |
| Chicago | deniz cigdem damla,GÜRBİLEK Mehmet,KOC Mehmet Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer. Türk Biyokimya Dergisi 43, no.2 (2018): 159 - 166. 10.1515/tjb-2017-0215 |
| MLA | deniz cigdem damla,GÜRBİLEK Mehmet,KOC Mehmet Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer. Türk Biyokimya Dergisi, vol.43, no.2, 2018, ss.159 - 166. 10.1515/tjb-2017-0215 |
| AMA | deniz c,GÜRBİLEK M,KOC M Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer. Türk Biyokimya Dergisi. 2018; 43(2): 159 - 166. 10.1515/tjb-2017-0215 |
| Vancouver | deniz c,GÜRBİLEK M,KOC M Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer. Türk Biyokimya Dergisi. 2018; 43(2): 159 - 166. 10.1515/tjb-2017-0215 |
| IEEE | deniz c,GÜRBİLEK M,KOC M "Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer." Türk Biyokimya Dergisi, 43, ss.159 - 166, 2018. 10.1515/tjb-2017-0215 |
| ISNAD | deniz, cigdem damla vd. "Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer". Türk Biyokimya Dergisi 43/2 (2018), 159-166. https://doi.org/10.1515/tjb-2017-0215 |
