The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase
Yıl: 2018 Cilt: 43 Sayı: 5 Sayfa Aralığı: 549 - 556 Metin Dili: İngilizce DOI: 10.1515/tjb-2017-0154 İndeks Tarihi: 08-10-2019
The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase
Öz: Objective: Conflicting data are available in literatureregarding the effects of vitamin D (VitD) supplementationdiet on lipid panel. Therefore, we had the purpose to evaluatethe effects of VitD supplementation on lipid panel bya controlled experimental study, and those of VitD supplementationon oxidative stress index (OSI) and paraoxonase-1 (PON1) values in healthy and hypercholesterolemicmale rabbits.Methods: Thirty New Zealand rabbits were randomly separatedinto control, VD, HC + VD and HC groups. Control andVD groups were fed with standard chow, whereas HC + VDand HC groups were fed with 0.5% cholesterol chow aperiod of 8 weeks. During this period, VD and HC + VDgroups were orally administered with 300 IU/kg/day VitD.Results: The increase in serum total cholesterol (TC) andOSI level of HC group were significant compared to thosein HC + VD group. Decreases in serum HDL-cholesterol(HDL-C) and TC levels of VD group were significant withinthe groups.Conclusion: Without any doubt it is important that appliedVitD level should be in the ideal range for healthy living.However, it is also necessary to increase the serum HDL-Clevel (and hence PON1), which is decreases as a result ofVitD supplementation. Therefore, we believe that duringVitD supplementation, regular physical activity should beperformed to increases serum HDL-C.
Anahtar Kelime: Konular:
Sağlıklı ve hiperkolesterolemik tavşanlara vitamin D ilavesinin OSI ve paraoksonaz düzeylerine etkileri
Öz: Amaç: Literatürde, diyete D vitamini (VitD) ilavesinin lipit paneli üzerine etkisi hakkında birbirinden farklı sonuçlar bulunmaktadır. Bu yüzden projemizde kontrollü deneysel bir çalışma ile, sağlıklı ve hiperkolesterolemik erkek tavşanlara VitD ilavesinin lipit paneli üzerine etkisine, ve yine VitD ilavesinin oksidatif stress indeksi (OSI) ve paraoksonaz- 1 (PON-1) değerleri üzerine etkilerini araştırmayı amaçladık. Metod: 30 adet yeni zellanda tavşanı rastgele control, VD, HC + VD ve HC gruplarına ayrıldı. Kontrol ve VD grupları normal tavşan pelet yemiyle, HC + VD ve HC grupları ise önceden hazırlanmış olan % 0.5 kolesterollü yem ile 8 hafta süresince beslenildi. Bu süreçte VD ve HC + VD gruplarına oral yoldan 300 IU/kg/gün VitD verildi. Bulgular: HC + VD grubuna göre; HC grubu serum total kolesterol (TC) ve OSI seviyesindeki artış anlamlı bulundu. VD grubu, grup içi serum HDL kolesterol (HDL-C) ve TC seviyelerindeki azalışlar anlamlı bulundu. Sonuç: Kuşkusuz, sağlıklı bir yaşam için kan VitD seviyemizin ideal aralıkta olması önemlidir. Ancak VitD takviyesi sonucunda azalan serum HDL-C (dolayısı ile PON1) seviyesini, artırmak da gerekmektedir. Dolayısı ile VitD takviyesi ile birlikte, serum HDL-C’yi artıran, düzenli fiziksel aktivite yapılması gerektiğini düşünüyoruz.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | KOCABAŞ R, AKÖZ M (2018). The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase. , 549 - 556. 10.1515/tjb-2017-0154 |
| Chicago | KOCABAŞ Rahim,AKÖZ MEHMET The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase. (2018): 549 - 556. 10.1515/tjb-2017-0154 |
| MLA | KOCABAŞ Rahim,AKÖZ MEHMET The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase. , 2018, ss.549 - 556. 10.1515/tjb-2017-0154 |
| AMA | KOCABAŞ R,AKÖZ M The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase. . 2018; 549 - 556. 10.1515/tjb-2017-0154 |
| Vancouver | KOCABAŞ R,AKÖZ M The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase. . 2018; 549 - 556. 10.1515/tjb-2017-0154 |
| IEEE | KOCABAŞ R,AKÖZ M "The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase." , ss.549 - 556, 2018. 10.1515/tjb-2017-0154 |
| ISNAD | KOCABAŞ, Rahim - AKÖZ, MEHMET. "The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase". (2018), 549-556. https://doi.org/10.1515/tjb-2017-0154 |
| APA | KOCABAŞ R, AKÖZ M (2018). The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase. Türk Biyokimya Dergisi, 43(5), 549 - 556. 10.1515/tjb-2017-0154 |
| Chicago | KOCABAŞ Rahim,AKÖZ MEHMET The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase. Türk Biyokimya Dergisi 43, no.5 (2018): 549 - 556. 10.1515/tjb-2017-0154 |
| MLA | KOCABAŞ Rahim,AKÖZ MEHMET The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase. Türk Biyokimya Dergisi, vol.43, no.5, 2018, ss.549 - 556. 10.1515/tjb-2017-0154 |
| AMA | KOCABAŞ R,AKÖZ M The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase. Türk Biyokimya Dergisi. 2018; 43(5): 549 - 556. 10.1515/tjb-2017-0154 |
| Vancouver | KOCABAŞ R,AKÖZ M The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase. Türk Biyokimya Dergisi. 2018; 43(5): 549 - 556. 10.1515/tjb-2017-0154 |
| IEEE | KOCABAŞ R,AKÖZ M "The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase." Türk Biyokimya Dergisi, 43, ss.549 - 556, 2018. 10.1515/tjb-2017-0154 |
| ISNAD | KOCABAŞ, Rahim - AKÖZ, MEHMET. "The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase". Türk Biyokimya Dergisi 43/5 (2018), 549-556. https://doi.org/10.1515/tjb-2017-0154 |
