Yıl: 2018 Cilt: 48 Sayı: 1 Sayfa Aralığı: 18 - 24 Metin Dili: İngilizce DOI: 10.5152/IstanbulJPharm.2018.396764 İndeks Tarihi: 21-10-2019

In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation

Öz:
Prevention and treatment of noncommunicable diseases such as neurodegenerative diseases, diabetes, and hyperpigmentationusing medicinal plants has attracted increasing attention during the past few decades. In this study, Colutea cilicicaBoiss. & Balansa extracts (ethyl acetate, methanol, and water) were evaluated against key enzymes involved in neurodegenerativediseases, diabetes, and hyperpigmentation. The antioxidant (free radical scavenging, reducing power, β-carotene/linoleic acid, and phosphomolybdenum) and metal chelation properties were also investigated. The methanol extracts of C.cilicica vigorously inhibited the activities of acetylcholinesterase and butyrylcholinesterase (1.33 and 0.68 mg galantamineequivalents (GALAE)/g extract, respectively). It was observed that C. cilicica extracts possessed a higher inhibitory potentialfor α-glucosidase (2.71–1.23 mmol acarbose equivalents (ACAE)/g extract) than that for α-amylase (0.57–0.12 mmol ACAE/gextract). The water extract of C. cilicica showed potent radical scavenging capacity against DPPH (2, 2-diphenyl-1-picrylhydrazyl)and ABTS (2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (42.46 and 57.70 mg trolox equivalents (TE)/g extract,respectively). Phytochemical determination showed that C. cilicica water extract (17.26 mg rutin equivalents (RE)/g extract)was rich in flavonoids compared with ethyl acetate and methanol extracts (2.78 and 2.83 mg RE/g extract, for the respectiveextracts). These findings reveal the interesting potential of C. cilicica as a valuable source of phytochemicals that can be usedagainst common noncommunicable diseases, particularly against enzymes involved in neurodegenerative diseases.
Anahtar Kelime:

Konular: Farmakoloji ve Eczacılık
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA UYSAL Ş, Ceylan R, Aktumsek A, GÜLER G, PİCOT C, Zengin G, MAHOMOODALLY M (2018). In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation. , 18 - 24. 10.5152/IstanbulJPharm.2018.396764
Chicago UYSAL ŞENGÜL,Ceylan Ramazan,Aktumsek Abdurrahman,GÜLER GÖKALP ÖZMEN,PİCOT Carene,Zengin Gokhan,MAHOMOODALLY M. Fawzi In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation. (2018): 18 - 24. 10.5152/IstanbulJPharm.2018.396764
MLA UYSAL ŞENGÜL,Ceylan Ramazan,Aktumsek Abdurrahman,GÜLER GÖKALP ÖZMEN,PİCOT Carene,Zengin Gokhan,MAHOMOODALLY M. Fawzi In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation. , 2018, ss.18 - 24. 10.5152/IstanbulJPharm.2018.396764
AMA UYSAL Ş,Ceylan R,Aktumsek A,GÜLER G,PİCOT C,Zengin G,MAHOMOODALLY M In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation. . 2018; 18 - 24. 10.5152/IstanbulJPharm.2018.396764
Vancouver UYSAL Ş,Ceylan R,Aktumsek A,GÜLER G,PİCOT C,Zengin G,MAHOMOODALLY M In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation. . 2018; 18 - 24. 10.5152/IstanbulJPharm.2018.396764
IEEE UYSAL Ş,Ceylan R,Aktumsek A,GÜLER G,PİCOT C,Zengin G,MAHOMOODALLY M "In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation." , ss.18 - 24, 2018. 10.5152/IstanbulJPharm.2018.396764
ISNAD UYSAL, ŞENGÜL vd. "In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation". (2018), 18-24. https://doi.org/10.5152/IstanbulJPharm.2018.396764
APA UYSAL Ş, Ceylan R, Aktumsek A, GÜLER G, PİCOT C, Zengin G, MAHOMOODALLY M (2018). In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation. Istanbul Journal of Pharmacy, 48(1), 18 - 24. 10.5152/IstanbulJPharm.2018.396764
Chicago UYSAL ŞENGÜL,Ceylan Ramazan,Aktumsek Abdurrahman,GÜLER GÖKALP ÖZMEN,PİCOT Carene,Zengin Gokhan,MAHOMOODALLY M. Fawzi In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation. Istanbul Journal of Pharmacy 48, no.1 (2018): 18 - 24. 10.5152/IstanbulJPharm.2018.396764
MLA UYSAL ŞENGÜL,Ceylan Ramazan,Aktumsek Abdurrahman,GÜLER GÖKALP ÖZMEN,PİCOT Carene,Zengin Gokhan,MAHOMOODALLY M. Fawzi In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation. Istanbul Journal of Pharmacy, vol.48, no.1, 2018, ss.18 - 24. 10.5152/IstanbulJPharm.2018.396764
AMA UYSAL Ş,Ceylan R,Aktumsek A,GÜLER G,PİCOT C,Zengin G,MAHOMOODALLY M In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation. Istanbul Journal of Pharmacy. 2018; 48(1): 18 - 24. 10.5152/IstanbulJPharm.2018.396764
Vancouver UYSAL Ş,Ceylan R,Aktumsek A,GÜLER G,PİCOT C,Zengin G,MAHOMOODALLY M In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation. Istanbul Journal of Pharmacy. 2018; 48(1): 18 - 24. 10.5152/IstanbulJPharm.2018.396764
IEEE UYSAL Ş,Ceylan R,Aktumsek A,GÜLER G,PİCOT C,Zengin G,MAHOMOODALLY M "In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation." Istanbul Journal of Pharmacy, 48, ss.18 - 24, 2018. 10.5152/IstanbulJPharm.2018.396764
ISNAD UYSAL, ŞENGÜL vd. "In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation". Istanbul Journal of Pharmacy 48/1 (2018), 18-24. https://doi.org/10.5152/IstanbulJPharm.2018.396764