Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey

Demir, Kadir; ÖKTEN, Atilla; Badur, selim; Beşışık, Fatih; ÇAKALOĞLU, Yılmaz; PINARBAŞI, Binnur; İBRİŞİM, Duygu; BOZACI, Mürvet; Kaymakoglu, Sabahattin; Akyuz, Filiz

Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey

Yılmaz ÇAKALOĞLU, (İstanbul Üniversitesi, Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, İstanbul, Türkiye)

Filiz AKYÜZ, (İstanbul Üniversitesi, Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, İstanbul, Türkiye)

Mürvet BOZACI, (İstanbul Üniversitesi, Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, İstanbul, Türkiye)

Duygu İBRİŞİM, (İstanbul Üniversitesi, Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, İstanbul, Türkiye)

Binnur PINARBAŞI, (İstanbul Üniversitesi, Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, İstanbul, Türkiye)

Kadir DEMİR, (İstanbul Üniversitesi, Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, İstanbul, Türkiye)

Sabahattin KAYMAKOĞLU, (İstanbul Üniversitesi, Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, İstanbul, Türkiye)

Fatih BEŞIŞIK, (İstanbul Üniversitesi, Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, İstanbul, Türkiye)

Selim BADUR, (İstanbul Üniversitesi, Tıp Fakültesi, Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

Atilla ÖKTEN (İstanbul Üniversitesi, Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, İstanbul, Türkiye)

Turkish Journal of Gastroenterology

3 0

Yıl: 2008 Cilt: 19 Sayı: 2 Sayfa Aralığı: 104 - 108 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey

Öz:

Amaç: SEN virus paranteral yolla bulaşır ve transfüzyon sonrası hepatite neden olabilir. Klinik önemi ve sıklığı kronik C ve B hepatitli hastalarda araştırılmıştır, ancak kronik D hepatitinde önemi bilinmemektedir. Bu çalışmada amaç Türkiye’de kronik C, B ve delta hepatitinde SEN virus-H sıklığı ve klinik önemini belirlemektir. Yöntem: Seksen beş kronik viral hepatitli hasta (30 HCV, 30 HBV ve 25 HDV) ve 43 sağlıklı kan vericisinde SEN virus-H araştırılmıştır. Hepatit B, C ve D hastaları nda sırasıyla HBV DNA, HCV RNA ve HDV RNA pozitif idi. SEN virus-H DNA’sı serumdan DNA ekstraksiyonu yapıldı ktan sonra (NucleoSpin blood; Macherey-Nagel GmbH & Co KG, Germany) seminested polimeraz zincir reaksiyonu ile (L2AS, C5S primer in first step, L2AS, D11 in second step) araştırılmıştır. Bulgular: SEN virus-H DNA pozitifliği, kronik C, B, D hepatitinde ve sağlıklı kan vericilerinde sırasıyla 7/30(23.3%), 10/30 (33.3%), 6/25(24%), 7/43(16.2%) olarak saptandı. Kronik viral hepatitli hastalarda, SEN virus-H pozitif ve negatif hastalar arasında klinik özellikler ve tedaviye cevap açısından farklılık saptanmadı. Sonuç: SEN virus kronik viral hepatitli hastalarda sağlıklı kan vericilerinden daha fazladır. Bu sonuçlar, SEN virusun kronik viral hepatitde tedavi cevabı ve klinik seyirde etkili olmadığı nı göstermektedir.

Anahtar Kelime: Hepatit B, kronik Kan vericileri DNA virüs enfeksiyonları Genotip Tedavi sonucu Torque teno virüs Eş tanı DNA, viral Hepatit D, kronik Yaygınlık Hepatit C, kronik gamma-glutamiltranferaz Aspartat aminotransferazlar Geriyedönük çalışma Alkalin fosfataz

Konular: Cerrahi

Türkiye’de kronik B, C ve D hepatit infeksiyonlarında SEN-H virüsünün klinik önemi ve sıklığı

Öz:

Background/aims: SEN viruses are transmitted parenterally and can cause post-transfusion hepatitis. The prevalence and clinical significance of SEN viruses have been investigated in patients with chronic hepatitis C and B but not in D. We aimed to determine the prevalence and clinical significance of SEN viruses- H in patients with chronic hepatitis C, B and delta in Turkey. Methods: SEN viruses-H was analyzed in 85 patients with chronic viral hepatitis (30 HCV, 30 HBV and 25 HDV) and 43 non-professional blood donors. HBV DNA, HCV RNA and HDV RNA were positive in patients with hepatitis B, C and D, respectively. SEN viruses-H DNA was detected by semi-nested polymerase chain reaction method (L2AS, C5S primer in first step, L2AS, D11 in second step) after extraction of DNA from sera (NucleoSpin blood; Macherey-Nagel GmbH & Co KG, Germany). Results: SEN viruses-H DNA was found to be positive in 7/30 (23.3%), 10/30 (33.3%), 6/25 (24%), and 7/43 (16.2%) of patients with chronic C, B, and D hepatitis and healthy blood donors, respectively. There was no significant difference in clinical features and treatment response between SEN viruses- H-positive and -negative patients with chronic viral hepatitis. Conclusions: SEN viruses is more frequent in chronic hepatitis patients than in healthy blood donors. These results indicate that SEN viruses has no effect on the clinical course and treatment response of chronic viral hepatitis.

Anahtar Kelime: Comorbidity DNA, Viral Hepatitis D, Chronic Prevalence Hepatitis C, Chronic gamma-Glutamyltransferase Aspartate Aminotransferases Retrospective Studies Alkaline Phosphatase Hepatitis B, Chronic Blood Donors DNA Virus Infections Genotype Treatment Outcome Torque teno virus

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÇAKALOĞLU Y, Akyuz F, BOZACI M, İBRİŞİM D, PINARBAŞI B, Demir K, Kaymakoglu S, Beşışık F, Badur s, ÖKTEN A (2008). Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey. , 104 - 108.
Chicago	ÇAKALOĞLU Yılmaz,Akyuz Filiz,BOZACI Mürvet,İBRİŞİM Duygu,PINARBAŞI Binnur,Demir Kadir,Kaymakoglu Sabahattin,Beşışık Fatih,Badur selim,ÖKTEN Atilla Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey. (2008): 104 - 108.
MLA	ÇAKALOĞLU Yılmaz,Akyuz Filiz,BOZACI Mürvet,İBRİŞİM Duygu,PINARBAŞI Binnur,Demir Kadir,Kaymakoglu Sabahattin,Beşışık Fatih,Badur selim,ÖKTEN Atilla Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey. , 2008, ss.104 - 108.
AMA	ÇAKALOĞLU Y,Akyuz F,BOZACI M,İBRİŞİM D,PINARBAŞI B,Demir K,Kaymakoglu S,Beşışık F,Badur s,ÖKTEN A Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey. . 2008; 104 - 108.
Vancouver	ÇAKALOĞLU Y,Akyuz F,BOZACI M,İBRİŞİM D,PINARBAŞI B,Demir K,Kaymakoglu S,Beşışık F,Badur s,ÖKTEN A Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey. . 2008; 104 - 108.
IEEE	ÇAKALOĞLU Y,Akyuz F,BOZACI M,İBRİŞİM D,PINARBAŞI B,Demir K,Kaymakoglu S,Beşışık F,Badur s,ÖKTEN A "Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey." , ss.104 - 108, 2008.
ISNAD	ÇAKALOĞLU, Yılmaz vd. "Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey". (2008), 104-108.

APA	ÇAKALOĞLU Y, Akyuz F, BOZACI M, İBRİŞİM D, PINARBAŞI B, Demir K, Kaymakoglu S, Beşışık F, Badur s, ÖKTEN A (2008). Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey. Turkish Journal of Gastroenterology, 19(2), 104 - 108.
Chicago	ÇAKALOĞLU Yılmaz,Akyuz Filiz,BOZACI Mürvet,İBRİŞİM Duygu,PINARBAŞI Binnur,Demir Kadir,Kaymakoglu Sabahattin,Beşışık Fatih,Badur selim,ÖKTEN Atilla Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey. Turkish Journal of Gastroenterology 19, no.2 (2008): 104 - 108.
MLA	ÇAKALOĞLU Yılmaz,Akyuz Filiz,BOZACI Mürvet,İBRİŞİM Duygu,PINARBAŞI Binnur,Demir Kadir,Kaymakoglu Sabahattin,Beşışık Fatih,Badur selim,ÖKTEN Atilla Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey. Turkish Journal of Gastroenterology, vol.19, no.2, 2008, ss.104 - 108.
AMA	ÇAKALOĞLU Y,Akyuz F,BOZACI M,İBRİŞİM D,PINARBAŞI B,Demir K,Kaymakoglu S,Beşışık F,Badur s,ÖKTEN A Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey. Turkish Journal of Gastroenterology. 2008; 19(2): 104 - 108.
Vancouver	ÇAKALOĞLU Y,Akyuz F,BOZACI M,İBRİŞİM D,PINARBAŞI B,Demir K,Kaymakoglu S,Beşışık F,Badur s,ÖKTEN A Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey. Turkish Journal of Gastroenterology. 2008; 19(2): 104 - 108.
IEEE	ÇAKALOĞLU Y,Akyuz F,BOZACI M,İBRİŞİM D,PINARBAŞI B,Demir K,Kaymakoglu S,Beşışık F,Badur s,ÖKTEN A "Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey." Turkish Journal of Gastroenterology, 19, ss.104 - 108, 2008.
ISNAD	ÇAKALOĞLU, Yılmaz vd. "Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey". Turkish Journal of Gastroenterology 19/2 (2008), 104-108.