The efficacy of topical thiocolchicoside (Muscoril®) in the treatment of acute cervical myofascial pain syndrome: A single-blind, randomized, prospective, phase IV clinical study

ESMAEİLZADEH, Sina; BASAT, Hande; Ketenci, Ayşegül

The efficacy of topical thiocolchicoside (Muscoril®) in the treatment of acute cervical myofascial pain syndrome: A single-blind, randomized, prospective, phase IV clinical study

Ayşegül KETENCİ, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, İstanbul, Türkiye)

Hande BASAT, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, İstanbul, Türkiye)

Sina ESMAEİLZADEH (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, İstanbul, Türkiye)

Ağrı

38 0

Yıl: 2009 Cilt: 21 Sayı: 3 Sayfa Aralığı: 95 - 103 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The efficacy of topical thiocolchicoside (Muscoril®) in the treatment of acute cervical myofascial pain syndrome: A single-blind, randomized, prospective, phase IV clinical study

Öz:

Amaç: Miyofasiyal ağrı sendromu, bir veya birkaç kas ve/veya bağ dokusunda bulunan ve tetik nokta denilen hipersensitif bölgelerle kendini gösteren; ağrı, kas spazmı, hassasiyet, sertlik, hareket kısıtlılığı, güçsüzlük ve nadiren otonomik disfonksiyon yapabilen bir rahatsızlıktır. Miyofasiyal ağrı sendromunun tedavisinde çeşitli tedavi yöntemleri kullanılmıştır. Bu tedaviler arasında germe ve sprey tekniği, tetik nokta enjeksiyonu, kuru iğneleme, çeşitli ilaç tedavileri ve fizik tedavi yöntemlerinin etkinliği gösterilmiştir. Gereç ve Yöntem: Çalışmaya akut miyofasiyal ağrı sendromulu 65 hasta alındı. Hastalar üç gruba randomize edildi. İlk gruba tetik noktalar üzerine tiyokolşikosid merhem, ikinci gruba tetik noktalar üzerine tiyokolşikosid ampul intramuskuler, üçüncü gruba ikisi birlikte uygulandı. Tedaviler beş gün boyunca yapıldı. Algometrik ve goniometrik ölçümler, vizüel analog skala (VAS) ile ağrı şiddeti değerlendirimi birinci, üçüncü ve beşinci günde yapıldı. Bulgular: VAS ile ölçülen ağrı şiddeti birinci günden itibaren monoterapi gruplarında, üçüncü günden itibaren tüm gruplarda anlamlı oranda düştü. Her üç grupta da sağa lateral fleksiyonda anlamlı düzelme gözlenirken, kombine tedavi grubunda sola lateral fleksiyonda anlamlı düzelme saptanmadı. Sonuç: Tiyokolşikosid, miyofasiyal ağrı sendromu tedavisinde kullanılabilir ve merhem formu özellikle enjeksiyon uygulanamayan hastalar için iyi bir alternatif oluşturabilir.

Anahtar Kelime:

Konular: Cerrahi

Servikal miyofasiyal ağrı sendromunun tedavisinde topikal tiyokolşikosid'in (Muscoril®) etkinliği: Tek-kör, randomize, prospektif, faz IV klinik çalışma

Öz:

Objectives: Myofascial pain syndrome is a disorder characterized by hypersensitive sites called trigger points at one or more muscles and/or connective tissue, leading to pain, muscle spasm, sensitivity, rigor, limitation of movement, weakness, and rarely, autonomic dysfunction. Various treatment methods have been used in the treatment of myofascial pain syndrome. Among these, stretch and spray technique, trigger point injection, dry needling, pharmacological agents, and physical therapy modalities have been proven effective. Methods: Sixty-five patients with acute myofascial pain syndrome were recruited into the study. Patients were randomized into three groups. The first group received thiocolchicoside ointment onto the trigger points, the second group received 8 mg thiocolchicoside intramuscular injection to the trigger points, and the third group received both treatments. Treatment was applied for 5 consecutive days. Algometric and goniometric measurements and pain severity assessments with visual analog scale (VAS) were repeated on the first, third, and fifth days of the treatment. Results: Pain severity measured with VAS significantly improved after the first day in the mono-therapy groups and after the third day in all groups. While significant improvement was observed in all three groups in right lateral flexion measurements, no significant changes were observed in the combined treatment group in left lateral flexion measurements. Conclusion: Thiocolchicoside can be used in the treatment of myofascial pain syndrome. The ointment form may be a good alternative, particularly in patients who cannot receive injections.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Ketenci A, BASAT H, ESMAEİLZADEH S (2009). The efficacy of topical thiocolchicoside (Muscoril®) in the treatment of acute cervical myofascial pain syndrome: A single-blind, randomized, prospective, phase IV clinical study. , 95 - 103.
Chicago	Ketenci Ayşegül,BASAT Hande,ESMAEİLZADEH Sina The efficacy of topical thiocolchicoside (Muscoril®) in the treatment of acute cervical myofascial pain syndrome: A single-blind, randomized, prospective, phase IV clinical study. (2009): 95 - 103.
MLA	Ketenci Ayşegül,BASAT Hande,ESMAEİLZADEH Sina The efficacy of topical thiocolchicoside (Muscoril®) in the treatment of acute cervical myofascial pain syndrome: A single-blind, randomized, prospective, phase IV clinical study. , 2009, ss.95 - 103.
AMA	Ketenci A,BASAT H,ESMAEİLZADEH S The efficacy of topical thiocolchicoside (Muscoril®) in the treatment of acute cervical myofascial pain syndrome: A single-blind, randomized, prospective, phase IV clinical study. . 2009; 95 - 103.
Vancouver	Ketenci A,BASAT H,ESMAEİLZADEH S The efficacy of topical thiocolchicoside (Muscoril®) in the treatment of acute cervical myofascial pain syndrome: A single-blind, randomized, prospective, phase IV clinical study. . 2009; 95 - 103.
IEEE	Ketenci A,BASAT H,ESMAEİLZADEH S "The efficacy of topical thiocolchicoside (Muscoril®) in the treatment of acute cervical myofascial pain syndrome: A single-blind, randomized, prospective, phase IV clinical study." , ss.95 - 103, 2009.
ISNAD	Ketenci, Ayşegül vd. "The efficacy of topical thiocolchicoside (Muscoril®) in the treatment of acute cervical myofascial pain syndrome: A single-blind, randomized, prospective, phase IV clinical study". (2009), 95-103.

APA	Ketenci A, BASAT H, ESMAEİLZADEH S (2009). The efficacy of topical thiocolchicoside (Muscoril®) in the treatment of acute cervical myofascial pain syndrome: A single-blind, randomized, prospective, phase IV clinical study. Ağrı, 21(3), 95 - 103.
Chicago	Ketenci Ayşegül,BASAT Hande,ESMAEİLZADEH Sina The efficacy of topical thiocolchicoside (Muscoril®) in the treatment of acute cervical myofascial pain syndrome: A single-blind, randomized, prospective, phase IV clinical study. Ağrı 21, no.3 (2009): 95 - 103.
MLA	Ketenci Ayşegül,BASAT Hande,ESMAEİLZADEH Sina The efficacy of topical thiocolchicoside (Muscoril®) in the treatment of acute cervical myofascial pain syndrome: A single-blind, randomized, prospective, phase IV clinical study. Ağrı, vol.21, no.3, 2009, ss.95 - 103.
AMA	Ketenci A,BASAT H,ESMAEİLZADEH S The efficacy of topical thiocolchicoside (Muscoril®) in the treatment of acute cervical myofascial pain syndrome: A single-blind, randomized, prospective, phase IV clinical study. Ağrı. 2009; 21(3): 95 - 103.
Vancouver	Ketenci A,BASAT H,ESMAEİLZADEH S The efficacy of topical thiocolchicoside (Muscoril®) in the treatment of acute cervical myofascial pain syndrome: A single-blind, randomized, prospective, phase IV clinical study. Ağrı. 2009; 21(3): 95 - 103.
IEEE	Ketenci A,BASAT H,ESMAEİLZADEH S "The efficacy of topical thiocolchicoside (Muscoril®) in the treatment of acute cervical myofascial pain syndrome: A single-blind, randomized, prospective, phase IV clinical study." Ağrı, 21, ss.95 - 103, 2009.
ISNAD	Ketenci, Ayşegül vd. "The efficacy of topical thiocolchicoside (Muscoril®) in the treatment of acute cervical myofascial pain syndrome: A single-blind, randomized, prospective, phase IV clinical study". Ağrı 21/3 (2009), 95-103.