Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen

AYHAN, HAKAN; AYHAN, Fatma; SÖKMEN, Nazlı; UYSAL, Seda; ÖZYAZICI, MİNE

Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen

Nazlı SÖKMEN, (Muğla Üniversitesi, Fen Fakültesi, Kimya Bölümü, Muğla, Türkiye)

Seda UYSAL, (Ege Üniversitesi, İzmir, Türkiye)

Fatma AYHAN, (Muğla Üniversitesi, Fen Fakültesi, Kimya Bölümü, Muğla, Türkiye)

Mine ÖZYAZICI, (Ege Üniversitesi, İzmir, Türkiye)

Hakan AYHAN (Muğla Üniversitesi, Fen Fakültesi, Kimya Bölümü, Muğla, Türkiye)

Hacettepe Journal of Biology and Chemistry

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Yıl: 2009 Cilt: 37 Sayı: 4 Sayfa Aralığı: 337 - 343 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen

Öz:

In this study, poly(ethylene glycol-diacrylate) (PEG-DA) hydrogels with two different concentrations, 30% and 50% w/w, were prepared by free radical polymerization method. Ethylene glycol dimethacrylate (EGDMA) and 2,2-dimethoxy-2-phenyl-acetophenone (DMPA) were used as cross-linking agent and photoinitiator, respectively. The model drug ketoprofen (KP) was incorporated into the hydrogel during photopolymerization and its release kinetics was tested spectrophotometrically at 256 nm in different buffer solutions of pH 7.5, 4.5, and 1.2. The results showed that the release of KP strongly depends on the dissolution of drug, initial polymer concentration, and the pH of the release medium. All of the obtained results were evaluated kinetically by first order and zero order, Higuchi and Hixon-Crowell kinetic models. The release mechanism was found to obey Higuchi and first order kinetics when the release data of the formulations were applied to the models in the different pH mediums.

Anahtar Kelime:

Konular: Biyoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	SÖKMEN N, UYSAL S, AYHAN F, ÖZYAZICI M, AYHAN H (2009). Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen. , 337 - 343.
Chicago	SÖKMEN Nazlı,UYSAL Seda,AYHAN Fatma,ÖZYAZICI MİNE,AYHAN HAKAN Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen. (2009): 337 - 343.
MLA	SÖKMEN Nazlı,UYSAL Seda,AYHAN Fatma,ÖZYAZICI MİNE,AYHAN HAKAN Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen. , 2009, ss.337 - 343.
AMA	SÖKMEN N,UYSAL S,AYHAN F,ÖZYAZICI M,AYHAN H Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen. . 2009; 337 - 343.
Vancouver	SÖKMEN N,UYSAL S,AYHAN F,ÖZYAZICI M,AYHAN H Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen. . 2009; 337 - 343.
IEEE	SÖKMEN N,UYSAL S,AYHAN F,ÖZYAZICI M,AYHAN H "Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen." , ss.337 - 343, 2009.
ISNAD	SÖKMEN, Nazlı vd. "Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen". (2009), 337-343.

APA	SÖKMEN N, UYSAL S, AYHAN F, ÖZYAZICI M, AYHAN H (2009). Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen. Hacettepe Journal of Biology and Chemistry, 37(4), 337 - 343.
Chicago	SÖKMEN Nazlı,UYSAL Seda,AYHAN Fatma,ÖZYAZICI MİNE,AYHAN HAKAN Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen. Hacettepe Journal of Biology and Chemistry 37, no.4 (2009): 337 - 343.
MLA	SÖKMEN Nazlı,UYSAL Seda,AYHAN Fatma,ÖZYAZICI MİNE,AYHAN HAKAN Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen. Hacettepe Journal of Biology and Chemistry, vol.37, no.4, 2009, ss.337 - 343.
AMA	SÖKMEN N,UYSAL S,AYHAN F,ÖZYAZICI M,AYHAN H Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen. Hacettepe Journal of Biology and Chemistry. 2009; 37(4): 337 - 343.
Vancouver	SÖKMEN N,UYSAL S,AYHAN F,ÖZYAZICI M,AYHAN H Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen. Hacettepe Journal of Biology and Chemistry. 2009; 37(4): 337 - 343.
IEEE	SÖKMEN N,UYSAL S,AYHAN F,ÖZYAZICI M,AYHAN H "Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen." Hacettepe Journal of Biology and Chemistry, 37, ss.337 - 343, 2009.
ISNAD	SÖKMEN, Nazlı vd. "Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen". Hacettepe Journal of Biology and Chemistry 37/4 (2009), 337-343.