Does the X-chromosome carry the gene responsible for bipolar disorder? an offspring with bipolar disorder and coexisting muscular dystrophy from a mother with bipolar disorder

EDGUNLU GOKDOGAN, Tuba; SAKALLI ÇETİN, Esin; DUVARCI, İbrahim

Does the X-chromosome carry the gene responsible for bipolar disorder? an offspring with bipolar disorder and coexisting muscular dystrophy from a mother with bipolar disorder

Tuba EDGUNLU GOKDOGAN, (Muğla Sıtkı Koçman Üniversitesi, Muğla, Türkiye)

İbrahim DUVARCI, (Muğla Sıtkı Koçman Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Muğla, Türkiye)

ESİN SAKALLI ÇETİN (Muğla Sıtkı Koçman Üniversitesi, Muğla, Türkiye)

Klinik Psikofarmakoloji Bülteni

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Yıl: 2013 Cilt: 23 Sayı: 3 Sayfa Aralığı: 267 - 271 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Does the X-chromosome carry the gene responsible for bipolar disorder? an offspring with bipolar disorder and coexisting muscular dystrophy from a mother with bipolar disorder

Öz:

Bipolar bozukluk aile, ikiz ve evlat edinme çalışmaları göre, güçlü bir genetik yapı göstermekte olup, bipolar bozukluktan sorumlu olan genler belirsizliğini koru- maktadır. Bu iletim şekli zayıf karakterize edilmiş iken, genetik çalışmalar X kromozomunun bipolar bozukluk- tan sorumlu olabileceğini düşündürmektedir. Müsküler distrofi, X-kromozomuna bağlı resesif geçişli bir hasta- lıktır. Bu vakada, bipolar bozukluğu olan bir annenin çocuğu olan ve bipolar bozukluğa eşlik eden müsküler distrofisi bulunan 35 yaşındaki bir erkek hasta sunuldu. Bu olgu bize, müsküler distrofi ve bipolar bozukluktan sorumlu genlerin X-kromozomu içinde birbirine yakın olabileceği olasılığının dikkate alınması gerektiğini gös- termektedir.

Anahtar Kelime:

Konular: Farmakoloji ve Eczacılık

X-kromozomu bipolar bozukluktan sorumlu geni taşıyor mu? bipolar bozukluğu olan bir annenin bipolar bozukluğu ve müsküler distrofisi olan oğlu

Öz:

According to family, twin and adoption studies, which consistently indicate a strong genetic component, the specific genes that are responsible for bipolar disorder remain unclear. While the mode of transmission is poorly characterized, genetic studies suggest that the X-chromosome may be responsible for bipolar disorder. Muscular dystrophy is an X-chromosome linked recessively inherited disorder. In this case, we present a 35 year-old male with bipolar disorder and coexisting muscular dystrophy whose mother has bipolar disorder. This case prompts us to consider the possibility that those genes responsible for muscular dystrophy and bipolar disorder might be in close proximity within the same chromosome, namely the X-chromosome.

Anahtar Kelime:

Konular: Farmakoloji ve Eczacılık

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık

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APA	EDGUNLU GOKDOGAN T, DUVARCI İ, SAKALLI ÇETİN E (2013). Does the X-chromosome carry the gene responsible for bipolar disorder? an offspring with bipolar disorder and coexisting muscular dystrophy from a mother with bipolar disorder. , 267 - 271.
Chicago	EDGUNLU GOKDOGAN Tuba,DUVARCI İbrahim,SAKALLI ÇETİN Esin Does the X-chromosome carry the gene responsible for bipolar disorder? an offspring with bipolar disorder and coexisting muscular dystrophy from a mother with bipolar disorder. (2013): 267 - 271.
MLA	EDGUNLU GOKDOGAN Tuba,DUVARCI İbrahim,SAKALLI ÇETİN Esin Does the X-chromosome carry the gene responsible for bipolar disorder? an offspring with bipolar disorder and coexisting muscular dystrophy from a mother with bipolar disorder. , 2013, ss.267 - 271.
AMA	EDGUNLU GOKDOGAN T,DUVARCI İ,SAKALLI ÇETİN E Does the X-chromosome carry the gene responsible for bipolar disorder? an offspring with bipolar disorder and coexisting muscular dystrophy from a mother with bipolar disorder. . 2013; 267 - 271.
Vancouver	EDGUNLU GOKDOGAN T,DUVARCI İ,SAKALLI ÇETİN E Does the X-chromosome carry the gene responsible for bipolar disorder? an offspring with bipolar disorder and coexisting muscular dystrophy from a mother with bipolar disorder. . 2013; 267 - 271.
IEEE	EDGUNLU GOKDOGAN T,DUVARCI İ,SAKALLI ÇETİN E "Does the X-chromosome carry the gene responsible for bipolar disorder? an offspring with bipolar disorder and coexisting muscular dystrophy from a mother with bipolar disorder." , ss.267 - 271, 2013.
ISNAD	EDGUNLU GOKDOGAN, Tuba vd. "Does the X-chromosome carry the gene responsible for bipolar disorder? an offspring with bipolar disorder and coexisting muscular dystrophy from a mother with bipolar disorder". (2013), 267-271.

APA	EDGUNLU GOKDOGAN T, DUVARCI İ, SAKALLI ÇETİN E (2013). Does the X-chromosome carry the gene responsible for bipolar disorder? an offspring with bipolar disorder and coexisting muscular dystrophy from a mother with bipolar disorder. Klinik Psikofarmakoloji Bülteni, 23(3), 267 - 271.
Chicago	EDGUNLU GOKDOGAN Tuba,DUVARCI İbrahim,SAKALLI ÇETİN Esin Does the X-chromosome carry the gene responsible for bipolar disorder? an offspring with bipolar disorder and coexisting muscular dystrophy from a mother with bipolar disorder. Klinik Psikofarmakoloji Bülteni 23, no.3 (2013): 267 - 271.
MLA	EDGUNLU GOKDOGAN Tuba,DUVARCI İbrahim,SAKALLI ÇETİN Esin Does the X-chromosome carry the gene responsible for bipolar disorder? an offspring with bipolar disorder and coexisting muscular dystrophy from a mother with bipolar disorder. Klinik Psikofarmakoloji Bülteni, vol.23, no.3, 2013, ss.267 - 271.
AMA	EDGUNLU GOKDOGAN T,DUVARCI İ,SAKALLI ÇETİN E Does the X-chromosome carry the gene responsible for bipolar disorder? an offspring with bipolar disorder and coexisting muscular dystrophy from a mother with bipolar disorder. Klinik Psikofarmakoloji Bülteni. 2013; 23(3): 267 - 271.
Vancouver	EDGUNLU GOKDOGAN T,DUVARCI İ,SAKALLI ÇETİN E Does the X-chromosome carry the gene responsible for bipolar disorder? an offspring with bipolar disorder and coexisting muscular dystrophy from a mother with bipolar disorder. Klinik Psikofarmakoloji Bülteni. 2013; 23(3): 267 - 271.
IEEE	EDGUNLU GOKDOGAN T,DUVARCI İ,SAKALLI ÇETİN E "Does the X-chromosome carry the gene responsible for bipolar disorder? an offspring with bipolar disorder and coexisting muscular dystrophy from a mother with bipolar disorder." Klinik Psikofarmakoloji Bülteni, 23, ss.267 - 271, 2013.
ISNAD	EDGUNLU GOKDOGAN, Tuba vd. "Does the X-chromosome carry the gene responsible for bipolar disorder? an offspring with bipolar disorder and coexisting muscular dystrophy from a mother with bipolar disorder". Klinik Psikofarmakoloji Bülteni 23/3 (2013), 267-271.