Objective: Migraine is one of the most encountered causes of headaches. Usually, it shows upamong young adults and may cause a decline in life standards and workforce loss. The exact causeof the disease is not known, and environmental factors and genetic predisposition are etiologicallyblamed. Dermatoglyphics are special shapes created by epidermis ridges. They occur during theintrauterine period and remain invariably for lifetime. However, several disorders that developdepending on genetic predisposition may cause deteriorations in the shape and ridge of thedermatoglyphics. Thus, dermatoglyphic samples of the fingertip and palm of patients diagnosedwith migraine were compared with control group and presented in accompanying with literature.Method: The dermatoglyphic data obtained from 51 patients and 70 healthy people (controlgroup), with digital scanner were transferred to computer environment. By using ImageJ program,atd, dat, adt angles, a-b ridge count, sample types of all fingers and ridge counts were calculated.Obtained data were loaded into SPSS 15.0 program. T-test, Mann-Whitney U and chi-square wereused in statistical assessment.Results: Both right and left hand fingerprint ridge counts, a-b ridge counts and total ridge countsof the patients with migraine increased. This increase was also significant except for right handlittle finger. Furthermore, atd angle in both hands of patients with migraine was statistically andsignificantly higher than healthy control group. However, the most frequent sample type in bothgroups except for men s right hand was ulnar loop.Conclusions: The deviation from normality in the distribution of dermatoglyphic samples supportthe genetic predisposition blamed in migraine etiology. Also, by studying the dermatoglyphicsamples, it is likely to detect the individuals with genetic predisposition in society. Hence, it maybe provided for the group in risk to avoid from the circumstances and environments that willtrigger their disease.