Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats

Ton, Ozlem; KIRIS, TALAT; OVALIOĞLU ÖZDEMİR, Ayşegül; TON, Tuğrul; BİLGE, Turgay

Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats

Tuğrul TON, (Haseki Eğitim ve Araştırma Hastanesi, İstanbul, Türkiye)

Ayşegül OVALIOĞLU ÖZDEMİR, (Haseki Eğitim ve Araştırma Hastanesi, İstanbul, Türkiye)

Özlem TON, (Şişli Etfal Eğitim ve Araştırma Hastanesi, İstanbul, Türkiye)

Turgay BİLGE, (Haseki Eğitim ve Araştırma Hastanesi, İstanbul, Türkiye)

Talat KIRIŞ (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Nöroşirurji Anabilim Dalı, İstanbul, Türkiye)

Turkish Neurosurgery

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Yıl: 2013 Cilt: 23 Sayı: 2 Sayfa Aralığı: 155 - 160 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats

Öz:

AMAÇ: Alfa lipoik asidin (α-LA) doza bağımlı etkileri bir sıçan vazospazm modelinde morfoloj ik olarak araştırılmıştır.yÖntem ve GereÇler: 32 sıçan dört gruba bölünmüştür: grup I = kontrol; grup II = vazospazm; grup III = vazospazm + düşük doz (20 mg/ kg) intraperitoneal α-LA uygulaması ve grup IV = vazospazm + yüksek doz (100 mg/kg) intraperitoneal α-LA uygulaması. Her grup için ışıkmikroskopu altında histoloj ik ve morfometrik incelemeler yapılmıştır.BULGUlAR: Ana vasküler duvar kalınlığı grup II ve IIIte grup I ile karşılaştırıldığında önemli bir artış göstermiştir (p<0,05). Grup II ve IVünistatistiksel olarak karşılaştırılması vasküler duvar kalınlığı açısından grup IVte önemli bir azalma ve vasküler lümen açısından yine grup IVteönemli bir artış göstermiştir (p<0,05). SONUÇ: α-LAnın yüksek doz tedavi grubunda duvar kalınlığını azaltıp lümen yüzey alanını arttırarak vazospazm etkilerini azalttığı gösterilmiştir.Mevcut çalışma yeterli dozda α-LAnın deneysel bir vazospazm modelinde potansiyel bir terapötik ajan olduğunu düşündürmektedir.

Anahtar Kelime:

Konular: Cerrahi

Sıçanlarda A lf a Lip oik Asidin Vazosp astik Femoral A rterde Doza Bağ ımlı Morf oloj ik Etkileri

Öz:

AIM: The dose dependent effects of alpha lipoic acid (α-LA) were investigated morphologically on rat vasospasm model.mAterIAl and methOds: 32 rats were divided into four groups: group I=control; group II=vasospasm; group III=vasospasm +low dose (20mg/kg) intraperitoneal α-LA administered; and group IV=vasospasm +high dose (100 mg/kg) intraperitoneal α-LA administered. Histologicaland morphometric examinations were carried out for each groups under light microscope.results: The mean vascular wall thickness displayed significant increase in group II and III compared with group I (p<.05). Statisticalcomparison of group II and IV, regarding vascular wall thickness showed a significant decrease in group IV, and regarding vascular lumen areashowed a significant increase in group IV (p<.05). COnClusIOn: It is demonstrated α-LA reduces the effects of vasospasm in high dose treatment group by decreasing the wall thickness andincreasing the lumen surface area. The present study suggests that adequate dose of α-LA is a potential therapeutic agent in experimentalvasospasm model.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	TON T, OVALIOĞLU ÖZDEMİR A, Ton O, BİLGE T, KIRIS T (2013). Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats. , 155 - 160.
Chicago	TON Tuğrul,OVALIOĞLU ÖZDEMİR Ayşegül,Ton Ozlem,BİLGE Turgay,KIRIS TALAT Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats. (2013): 155 - 160.
MLA	TON Tuğrul,OVALIOĞLU ÖZDEMİR Ayşegül,Ton Ozlem,BİLGE Turgay,KIRIS TALAT Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats. , 2013, ss.155 - 160.
AMA	TON T,OVALIOĞLU ÖZDEMİR A,Ton O,BİLGE T,KIRIS T Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats. . 2013; 155 - 160.
Vancouver	TON T,OVALIOĞLU ÖZDEMİR A,Ton O,BİLGE T,KIRIS T Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats. . 2013; 155 - 160.
IEEE	TON T,OVALIOĞLU ÖZDEMİR A,Ton O,BİLGE T,KIRIS T "Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats." , ss.155 - 160, 2013.
ISNAD	TON, Tuğrul vd. "Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats". (2013), 155-160.

APA	TON T, OVALIOĞLU ÖZDEMİR A, Ton O, BİLGE T, KIRIS T (2013). Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats. Turkish Neurosurgery, 23(2), 155 - 160.
Chicago	TON Tuğrul,OVALIOĞLU ÖZDEMİR Ayşegül,Ton Ozlem,BİLGE Turgay,KIRIS TALAT Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats. Turkish Neurosurgery 23, no.2 (2013): 155 - 160.
MLA	TON Tuğrul,OVALIOĞLU ÖZDEMİR Ayşegül,Ton Ozlem,BİLGE Turgay,KIRIS TALAT Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats. Turkish Neurosurgery, vol.23, no.2, 2013, ss.155 - 160.
AMA	TON T,OVALIOĞLU ÖZDEMİR A,Ton O,BİLGE T,KIRIS T Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats. Turkish Neurosurgery. 2013; 23(2): 155 - 160.
Vancouver	TON T,OVALIOĞLU ÖZDEMİR A,Ton O,BİLGE T,KIRIS T Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats. Turkish Neurosurgery. 2013; 23(2): 155 - 160.
IEEE	TON T,OVALIOĞLU ÖZDEMİR A,Ton O,BİLGE T,KIRIS T "Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats." Turkish Neurosurgery, 23, ss.155 - 160, 2013.
ISNAD	TON, Tuğrul vd. "Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats". Turkish Neurosurgery 23/2 (2013), 155-160.