Objective: Hospital infection is a major issue in developed and developing countries. Hospital infections may cause functional impairments, emotional stress, reduced quality of life or death. Also, it increases economic burden due to reasons such as longer hospitalization periods, loss of work, increase in the use of medicine, need for isolation, use of additional laboratory and other diagnostic methods. Methods: In this study, data about infection control program of a foundation hospital accredited by JCI, and its infection indicators, and preventive measures taken against infection during the periods between 2014 January-March and 2015 January-March were examined, and compared with 2013 infection rates of Republic of Turkey Ministry of Health. Results: In general, gross infection rate of the hospital decreased from the first three months of 2014 down to 0.39% in 2015. However. hospital infection incidence density (2.1%) in 2015 hadn't changed compared to 2014. Ventilator related pneumonias were the most seen nosocomial infections between January, and March 2014. Nosocomial pneumonia was the most frequently seen infection during the first three months of 2015. The maximum incidence of infections was seen in the intensive care unit (40%) during the first three months of 2014 Infections were most frequently seen in internal medicine (50%) during the first three months of 2015. Concusion: The Foundation Hospital has taken measures, performed infection risk analysis and surveillance studies, and produced and applied risk mitigating solutions.