Compliance, persistence, and preference outcomesof postmenopausal osteoporotic women receivinga flexible or fixed regimen of daily risedronate:A multicenter, prospective, parallel group study

ORAL, AYDAN; LORENC, Roman

Compliance, persistence, and preference outcomesof postmenopausal osteoporotic women receivinga flexible or fixed regimen of daily risedronate:A multicenter, prospective, parallel group study

Aydan ORAL, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, İstanbul, Türkiye)

Roman LORENC (Department of Biochemistry, Radioimmunology and Experimental Medicine, The Childrens Memorial Health Institute, Warsaw, Poland)

Acta Orthopaedica et Traumatologica Turcica

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Yıl: 2015 Cilt: 49 Sayı: 1 Sayfa Aralığı: 67 - 74 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Compliance, persistence, and preference outcomesof postmenopausal osteoporotic women receivinga flexible or fixed regimen of daily risedronate:A multicenter, prospective, parallel group study

Öz:

Objective: The aim of this study was to examine the level of compliance and persistence in patients with postmenopausal osteoporosis (OP) receiving daily risedronate (5 mg) with either fixed dosing of three different timing regimens (A: before breakfast; B: in-between meals; C: before bedtime) or with flexible dosing and the effect on urinary N-terminal telopeptide of Type 1 collagen (NTX-1). Methods: The study included 448 patients with postmenopausal OP. Patients were randomly assigned into six treatment groups each with a permutation of the treatment sequence (ABC, BCA, etc.) in the crossover phase (3x1 week) and randomized to 23 weeks of either the daily flexible (either regimen A, B or C) or fixed timing (only regimen A, B, or C) in the patient's preference phase. Urinary NTX-1 was tested.Results: A total of 433 patients participated in the patient's preference phase (49.7% preferred flexible and 50.3% fixed timing). There was no significant difference between the proportion of responders who were both compliant and persistent in the flexible (54.4%) and fixed regimens (53.7%) (p=0.8803). A significant difference between the flexible and fixed regimens was seen in persistence in favor of the flexible regimen (p=0.0306). There was no significant difference between the flexible and fixed regimens in terms of compliance (p=0.4611). Change in urinary NTX-1 did not show any difference between the two regimens. At the final visit, 51% of patients in the flexible and 55% in the fixed regimen group considered the used risedronate regimen as excellent or very good (p=0.1440).Conclusion: A flexible dosing with daily risedronate appears be a valuable option in terms of compliance and persistence for patients with postmenopausal OP

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik

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APA	ORAL A, LORENC R (2015). Compliance, persistence, and preference outcomesof postmenopausal osteoporotic women receivinga flexible or fixed regimen of daily risedronate:A multicenter, prospective, parallel group study. , 67 - 74.
Chicago	ORAL AYDAN,LORENC Roman Compliance, persistence, and preference outcomesof postmenopausal osteoporotic women receivinga flexible or fixed regimen of daily risedronate:A multicenter, prospective, parallel group study. (2015): 67 - 74.
MLA	ORAL AYDAN,LORENC Roman Compliance, persistence, and preference outcomesof postmenopausal osteoporotic women receivinga flexible or fixed regimen of daily risedronate:A multicenter, prospective, parallel group study. , 2015, ss.67 - 74.
AMA	ORAL A,LORENC R Compliance, persistence, and preference outcomesof postmenopausal osteoporotic women receivinga flexible or fixed regimen of daily risedronate:A multicenter, prospective, parallel group study. . 2015; 67 - 74.
Vancouver	ORAL A,LORENC R Compliance, persistence, and preference outcomesof postmenopausal osteoporotic women receivinga flexible or fixed regimen of daily risedronate:A multicenter, prospective, parallel group study. . 2015; 67 - 74.
IEEE	ORAL A,LORENC R "Compliance, persistence, and preference outcomesof postmenopausal osteoporotic women receivinga flexible or fixed regimen of daily risedronate:A multicenter, prospective, parallel group study." , ss.67 - 74, 2015.
ISNAD	ORAL, AYDAN - LORENC, Roman. "Compliance, persistence, and preference outcomesof postmenopausal osteoporotic women receivinga flexible or fixed regimen of daily risedronate:A multicenter, prospective, parallel group study". (2015), 67-74.

APA	ORAL A, LORENC R (2015). Compliance, persistence, and preference outcomesof postmenopausal osteoporotic women receivinga flexible or fixed regimen of daily risedronate:A multicenter, prospective, parallel group study. Acta Orthopaedica et Traumatologica Turcica, 49(1), 67 - 74.
Chicago	ORAL AYDAN,LORENC Roman Compliance, persistence, and preference outcomesof postmenopausal osteoporotic women receivinga flexible or fixed regimen of daily risedronate:A multicenter, prospective, parallel group study. Acta Orthopaedica et Traumatologica Turcica 49, no.1 (2015): 67 - 74.
MLA	ORAL AYDAN,LORENC Roman Compliance, persistence, and preference outcomesof postmenopausal osteoporotic women receivinga flexible or fixed regimen of daily risedronate:A multicenter, prospective, parallel group study. Acta Orthopaedica et Traumatologica Turcica, vol.49, no.1, 2015, ss.67 - 74.
AMA	ORAL A,LORENC R Compliance, persistence, and preference outcomesof postmenopausal osteoporotic women receivinga flexible or fixed regimen of daily risedronate:A multicenter, prospective, parallel group study. Acta Orthopaedica et Traumatologica Turcica. 2015; 49(1): 67 - 74.
Vancouver	ORAL A,LORENC R Compliance, persistence, and preference outcomesof postmenopausal osteoporotic women receivinga flexible or fixed regimen of daily risedronate:A multicenter, prospective, parallel group study. Acta Orthopaedica et Traumatologica Turcica. 2015; 49(1): 67 - 74.
IEEE	ORAL A,LORENC R "Compliance, persistence, and preference outcomesof postmenopausal osteoporotic women receivinga flexible or fixed regimen of daily risedronate:A multicenter, prospective, parallel group study." Acta Orthopaedica et Traumatologica Turcica, 49, ss.67 - 74, 2015.
ISNAD	ORAL, AYDAN - LORENC, Roman. "Compliance, persistence, and preference outcomesof postmenopausal osteoporotic women receivinga flexible or fixed regimen of daily risedronate:A multicenter, prospective, parallel group study". Acta Orthopaedica et Traumatologica Turcica 49/1 (2015), 67-74.