Journal Of Turgut Ozal Medical Center

BÜYÜKGEBİZ, Atilla; ÖZTÜRK, Birol

Journal Of Turgut Ozal Medical Center

Birol ÖZTÜRK, (İstanbul Bilgi Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, İstanbul, Türkiye)

Atilla BÜYÜKGEBİZ (İstanbul Bilgi Üniversitesi, Tıp Fakültesi, Çocuk Endokrinoloji Bölümü, İstanbul, Türkiye)

İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi

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Yıl: 2015 Cilt: 22 Sayı: 1 Sayfa Aralığı: 66 - 72 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Journal Of Turgut Ozal Medical Center

Öz:

Ekosistem üzerinde çok yaygın olarak bulunan ve sayıları giderek artan doğal veya sentetik, hormonal olarak aktif, endokrin sisteme toksik olan maddelere ve ksenohormonlara endokrin bozucular denmektedir. Çevrede bulunan veya tarımda kullanılan haşere ilaçları, bitki koruyucular, bitkilerin hızlı büyümesini artıran hormonal ilaçlar ve endüstriyel maddeler endokrin bozucuların listesini oluşturmaktadır. Endokrin bozucular intrauterine döneme etki ederek konjenital malformasyonlara yolaçabildiği gibi; postnatal dönemde üreme, immun sistem ve tiroid fonksiyonlar üzerine de olumsuz etki gösterirler. Endokrin bozucular hormonların biyosentezini, salınımını, transportunu veya yıkımını reseptör veya postreseptör aktivasyon yoluyla etkileyerek; östrojenik, antiöstrojenik, antiandrojenik veya androjenik etkiler ile gösterirler. Endokrin bozucuların erkek genital sistem üzerine etkileri, östrojenik etkilerinden dolayı daha çok gecikmiş puberte olarak gözükmektedir ve en önemli etkisini Leydig hücrelerinin androjen üretimini azaltarak göstermektedir. Özellikle promycine, linuron, vinclozin, p,p'DDT, dioxin, fitalatlar, genistein, resveratrol ve bisphenol A Leydig hücre fonksiyonunu etkileyen doğal veya sentetik kimyasallar arasında yer almaktadır. Kızlarda ise diethylstilbesterol, dichlorodiphenyltrichloroethane /dichlorodiphenyl-dichloro ethiylene, methoxyklor, bisphenol A, polychlorinatedbiphenyl, dioxinler ve fitalatlar gibi endokrin bozucular, östrojenik etkileri ile erken telarş ve puberte prekoksa neden olmaktadır. Kızlarda geç puberteye neden olan endokrin bozucular ise atrazin, trenbolan asetat, kurşun ve vinclozindir. Bu yazı endokrin bozucuların, hızlı büyüme dönemindeki çocukluk çağı ve adölesanların sürekli gelişim ve değişim halinde olan endokrin sistemleri üzerine etkilerini son yayınlar ışığında gözden geçirmektedir.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Effects of Environmental Chemicals and Drugs on Reproductive Endocrine System

Öz:

Commonly found in ecosystems, endocrine disruptors are a large group of natural or synthetic compounds and xenobiotics that are toxic to the endocrine system of a living organism. The pesticides, herbicides, and hormonally active substances that are widely used in agriculture and industrial compounds are among the endocrine disruptors. Endocrine disrupters interfere with the immune system, thyroid functions, reproductive systems, and intrauterine life of a living organism. Endocrine disruptors show their oestrogenic, anti-oestrogenic, antiandrogenic, and androgenic effects by activating hormone biosynthesis, secretion, transport, degradation, receptors, or postreceptors. Effects of endocrine disruptors on male genital tract can be observed in estrogenic effects that cause delayed puberty, and, more importantly, reduction in androgen production of Leydig cells. Promycine, linuron, vinclozin, p,p'DDT, dioxin, phthalates, genistein, resveratrol, and bisphenol A are among the natural or synthetic chemicals that alter Leydig cell function. On the other hand, endocrine disruptors such as diethylstilbesterol, dichlorodiphenyltrichloroethane/dichlorodiphenyl-dichloro ethylene , methoxychlor, bisphenol A, polychlorinated biphenyls A, polychlorinatedbiphenyl, dioxins, and phthalates cause premature thelarche and precocious puberty with their estrogenic effects in girls. Atrazine, trenbolan acetate, lead, and vinclozis are among the other endocrine disruptors that may cause late puberty in girls. This article is a review of the recent publications that study the influences of endocrine disruptors on endocrine systems during puberty and adolescence, the growth and development periods of children.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

1. Kavlock RJ, Daston GP, DeRosa C, Fenner-Crisp P, Gray LE, Kaattari S, et al. Research needs for the risk assesstment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop. Environ Health Perspect 1996;104:715-40.
2. Greim HA. The endocrine and reproductive system: advers effects of hormonally active substances? Pediatrics 2004;113:1070-5.
3. Abacı A, Demir K, Bober E, Büyükgebiz A. Endocrine disrupters - with special emphasis on sexual development. Pediatr Endocrinol Rev 2009;4:464-75.
4. Whaley DA, Keyes D, Khorrami B. Incorporation of endocrine disruption into chemical hazard scoring for pollution prevention and current list of endocrine disrupting chemicals. Drug Chem Toxicol 2001;24:359-420.
5. Landrigan PJ. Children as a vulnarable population. Int J Occup Med Environ Health 2004;17:175-7.
6. Suk WA, Collman GW. Genes and the environment: their impact on children's health. Environ Health Perspect 1998;106:817-20.
7. Suk WA, Murray K, Avakian MD. Environmental hazards to children's health in the modern world. Mutat Res 2003;544:235-42.
8. Crews D, Willingham E, Skipper JK. Endocrine disruptors: present issues, future directions. Q Rev Biol 200;75:243-60. 9. Phillips KP, Foster WG. Key developments in endocrine disrupters research and human health. J Toxicol Environ Health B Crit Rev 2008;11:322-44.
10. Ottinger MA, Lavoie ET, Thompson N, Bohannon M, Dean K, Quinn MJ Jr. Is the gonadrtropin releasing hormone system vulnarable to endocrine disruption in birds? Gen Comp Endocrinol 2009;163:104-8.
11. Svechnikov K, Izzo G, Landreah L, Weisser J, Söder O. Endocrine disruptors and leydig cell function. J Biomed Biotechnol 2010;25:1-10.
12. Ottinger MA, Wu JM, Hazelton JL, ve ark. Neuroendocrine and behavioral effects of embryonic exposure to endocrine disrupting chemicald in birds. Brain Res Bull 2005;65:199- 209.
13. Ünüvar T, Büyükgebiz A. Fetal and neonatal endocrine disrupters. J Clin Res Endocrinol 2012;4:51-60.
14. 14-Dattani M, Hindmarsh P. Normal and abnormal puberty. In: Brook C, Clayton P, Brown R, eds. Brook's Clinical Pediatric Endocrinology. New York: Blackwell Publishing; 2005. P. 182-210.
15. Sharpe RM. 'The oestrogen hypothesis-where do we stand now?' Int J Androl 2003;26:2-15.
16. Kelce WR, Stone CR, Laws SC, Gray L.E, Kemppanien JA, Wilson EM. 'Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist. Nature 1995;375:581-5.
17. McGray S, Henry PFP, Ottinger MA. Impact of vinclozolin exposure on Japanese quail reproduction. Environ Toxicol Chem 2001;20:2487-93.
18. Mutoh J, Taketoh J, Okumara K, Kagawa T, Ishida T, Ishii Y, et al. Fetal pituitary gonadotropin as an initial target of dioxin in its impairment of cholesterol transportation and steroidogenesis in rats. Endocrinol 2006;147:927-36.
19. Cheng CY, Wong EW, Lie PP, Li MW, Su L, Siu ER, et al. Environmental toxicant and male reproductive function. Spermatogenesis 2011;1:2-13.
20. Haeba MH, Hilscherova K, Mazurova E, Blaha L. Selectedc endocrine disrupting compounds (vizclozolin, flutamide, ketoconazole and dicofol): effects on survival, occurence of males, growth, molting and reproduction of Daphnia manga. Environ Sci Pollut Res Int 2008;15:222-7.
21. Ottinger MA, Quinn MR Jr, Lavoie E, Abdelnabi MA, Thompson N, Hazelton JL, et al. Consequences of endocrine disrupting chemical on reproductive endocrine function in birds:establishing reliable end points of exposure. Domest Anim Endocrinol 2005;29:411-9.
22. Castagna C, Absil P, Foidart A, Balthazar J. Systemic and intracerebroventricular injections of vasotocin inhibit appetitive and consummatory components of male sexual behavior in Japanese quail. Behav Neurosci 1998;112:233- 50.
23. Anderson RJ, Willis B, Phillips J, Oswald C, Zaneveld L. Delayed pubertal development of the male reproductive tract associated with chronic ethanol ingestion. Biochem Pharmacol 1987;36:2157-67.
24. Ottinger MA, Dean K, McKernan M, Quinn MJ. Endocrine Disruption of Reproduction in birds. In: Norris DO, Lopez KH, eds. Hormones and Reproduction of Vertebrates, 1st edition. USA; 2011. p. 239-60.
25. Quinn MJ Jr, Summitt CL, Ottinger MA. Consequences of in ovo exposure to p,p'-DDE on reproductive development and function in Japanese quail. Hormones and Behavior 2008;53:153-249.
26. Rasier G, Toppari J, Parent AS, Bourguignon JP. Female sexual maturation end reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: a review of rodent and and human data. Moll Cell Endocrinol 2006;254-255:187-201.
27. Kim J, Kim S, Huh K, Kim Y, Joung H, Park M. High serum isoflavone concentrations are associated with the risk of precocious puberty in Korean girls. Clin Endocrinol 2011;75:831-6.
28. Wolff MS, Teitelbaum SL, Pinney SM, Windham G, Liao L, Biro F, et al. Invetigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls. Environ Health Perspct 2010;118:1039-46.
29. Bateman HL, Patisaul HB. Disrupted female reproductive physiology following neonatal exposure to phytoestrogens or estrogen specific ligands is associated with decreased Gnrh activation and kisspeptin fiber density in the hypothalamus. Neurotoxicology 2008;29:988-97.
30. Chapin R, Haris MW, Davis BJ, Ward SM, Wilson RE, Mauney MA, et al. The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function. Fundam Appl Toxicol 1997;40:138-57
31. Rubin BS, Murray MK, Damasa DA, King JC, Soto AM. Perinatal exposure to low doses of Bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels. Environ Health Perspect 2001;109:675-80.
32. Adewale HB, Todd KL, Mickens JA, Patisaul HB. The impact of neonatal bisphenol-A exposure on sexually dimorphic hypotalamic nuclei in the female rat. Neurotoxicology. 2011;32:38-49.
33. Munoz-de-Toro M, Markey CM, Wadia PR, Luque EH, Rubin BS, Sonnenschein C, et al. Perinatal exposure to bisphenol A alters peripubertal mammary gland development in mice. Endocrinology 2005;146:4138-47.
34. McKee RH. Phthalate exposure and early telarche. Environ Health Perspect 2004;112:541-3.
35. Jurewicz J, Hanke W. Exposure to phthalates: reproductive outcome and children health. A review of epidemiological studies. Int J Occup Med Environ Health 2011;24:115-41.
36. Qiao L, Zheng L, Cai D. Study on the di-n-butyl phthalate and di-2-ethylhexyl phthalate level of girl serum related with precocious puberty in Shanghai. Wei Sheng Yan Jiu 2007;36:93-5.
37. Sathyanarayana S. Phthalates and children's health. Curr Probl Pediatr Adolesc Health Care 2008;38:34-49.
38. Kakeyema M, Sone H, Tohyama C. Perinatal exposure of female rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces central precocious puberty in offspring. J Endocrinol 2008;197:351-8.
39. Clark EJ, Norris DO, Jones RE. Interactions of gonadal steroids and pesticides (DDT, DDE) on gonaduct growth in larval tiger salamaders, Ambystoma tigrinium. Gen Comp Endocrinol 1998;109:94-105.
40. Quinn Jr, Lavoie ET, Ottinger MA. Reproductive toxicitiy of trenbolane acetate in embryonically exposed Japanese quail. Chemosphere 2007;66:1191-6.
41. Dearth RK, Hiney JK, Srivastava Vİ Les Dees W, Bratton GR. Low level lead (PB) exposure during gestation and lactation: assessment of effects on pubertal development in Fisher 344 and Sprague-Dawley female rats. Life Sci 2004;74:1139- 48.
42. Mendola P, Messer LC, Rappazzo K. Science linking environmental contaminant exposuress with fertility and reproductive health impacts in the adult female. Fertil Steril 2008;89:81-94.
43. Lavicoli I, Carelli G, Stanek EJ, Castellino N, Li Z, Calabrese EJ. Low doses of dietary lead are associated with a profound reduction in the time to onset of puberty in female mice. Reprod Toxicol 2006;22:586-90.
44. Gollenberg AL, Hediger ML, Lee PA, Himes JH, Louis GM. Association between lead and cadmium and reproductive hormones in peripubertal U.S. girls. Environ Health Perspect 2010;118:1782-7.
45. Wolff MS, Britton JA, Boguski L, Hochman S, Maloney N, Serra N, et al. Environmental exposures and puberty in inercity girls. Environ Res 2008;107:393-400.
46. Mendas G, Vuletic M, Galic N, Drevenkar V. Urinary metabolites as biomarkers of human exposure to atrazine: Atrazine mercapturate in agricultural workers. Toxicol Lett 2012;210:174-81.
47. Rinsky JL, Hopenhayn C, Golla V, Browning S, Bush HM. Atrazine exposure in public drinking water and preterm birth. Public Health Rep 2012;127:72-80.
48. Cragin LA, Kesner JS, Bachand AM, Barr AM, Meadows JW, Krieg EF, et al. Menstrual cycle characteristics and reproductive hormone levels in women exposed to atrazine in drinking water. Environ Res 2011;111:1293-301.
49. Lemos MF, van Gestel CA, Soares AM. Reproductive toxicity of the endocrine disrupters vinclozolin and bisphenol A in the terrestrial isopod Porcellio scaber (Latreille,1804). Chemosphere 2010;78:907-13.

APA	ÖZTÜRK B, BÜYÜKGEBİZ A (2015). Journal Of Turgut Ozal Medical Center. , 66 - 72.
Chicago	ÖZTÜRK Birol,BÜYÜKGEBİZ Atilla Journal Of Turgut Ozal Medical Center. (2015): 66 - 72.
MLA	ÖZTÜRK Birol,BÜYÜKGEBİZ Atilla Journal Of Turgut Ozal Medical Center. , 2015, ss.66 - 72.
AMA	ÖZTÜRK B,BÜYÜKGEBİZ A Journal Of Turgut Ozal Medical Center. . 2015; 66 - 72.
Vancouver	ÖZTÜRK B,BÜYÜKGEBİZ A Journal Of Turgut Ozal Medical Center. . 2015; 66 - 72.
IEEE	ÖZTÜRK B,BÜYÜKGEBİZ A "Journal Of Turgut Ozal Medical Center." , ss.66 - 72, 2015.
ISNAD	ÖZTÜRK, Birol - BÜYÜKGEBİZ, Atilla. "Journal Of Turgut Ozal Medical Center". (2015), 66-72.

APA	ÖZTÜRK B, BÜYÜKGEBİZ A (2015). Journal Of Turgut Ozal Medical Center. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, 22(1), 66 - 72.
Chicago	ÖZTÜRK Birol,BÜYÜKGEBİZ Atilla Journal Of Turgut Ozal Medical Center. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi 22, no.1 (2015): 66 - 72.
MLA	ÖZTÜRK Birol,BÜYÜKGEBİZ Atilla Journal Of Turgut Ozal Medical Center. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, vol.22, no.1, 2015, ss.66 - 72.
AMA	ÖZTÜRK B,BÜYÜKGEBİZ A Journal Of Turgut Ozal Medical Center. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi. 2015; 22(1): 66 - 72.
Vancouver	ÖZTÜRK B,BÜYÜKGEBİZ A Journal Of Turgut Ozal Medical Center. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi. 2015; 22(1): 66 - 72.
IEEE	ÖZTÜRK B,BÜYÜKGEBİZ A "Journal Of Turgut Ozal Medical Center." İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, 22, ss.66 - 72, 2015.
ISNAD	ÖZTÜRK, Birol - BÜYÜKGEBİZ, Atilla. "Journal Of Turgut Ozal Medical Center". İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi 22/1 (2015), 66-72.