The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model
Yıl: 2013 Cilt: 4 Sayı: 3 Sayfa Aralığı: 279 - 284 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model
Öz: Amaç: Antipsikotik ilaçların beyinde güçlü biyoelektrik aktivite etkilerinin olduğu bilinmektedir. Fakat tipik ve atipik antipsikotik ilaçlara bağlı olan elektroensefalografi (EEG) değişikliklerinin karşılaştırmalı çalışmaları tartışmalıdır. Biz bir rat modelinde tipik ve atipik antipsikotik ilaçların beyinde elektriksel aktivitesi üzerine olan etkilerini EEG ile karşılaştırmayı amaçladık. Yöntemler: Bu çalışmada, 35 adet erişkin erkek Sprague Dawley cinsi rat kullanıldı. Herbiri 7 adet rat içeren 5 adet grup oluşturuldu. Birinci grup kontrol grubu olarak kullanıldı ve intraperitoneal yolla 1 ml/kg salin verildi. Beş gün boyunca intraperitoneal olarak haloperidol (1 mg/kg) (grup 2), klorpromazin (5 mg/kg) (grup 3), olanzapin (1 mg/kg) (grup 4) ve ziprasidon (1 mg/kg) (grup 5) verildi. Beşinci günün sonunda bütün grupların 30 dakika EEG kaydı alındı.Bulgular: Haloperidol, klorpromazin, olanzapin ve ziprasidon gruplarında delta ve teta dalga yüzdelerinin salin verilen gruba göre anlamlı düzeyde yüksek olduğu görüldü (p<0.001). Olanzapin ve ziprosidon gruplarındaki teta dalgaları haloperidol ve klorpromazin grubuyla karşılaştırıldığında anlamlı düzeyde artmış olarak saptandı (p<0,05).Sonuç: Olanzapin ve ziprasidon tipik antipsikotik ilaçlara göre EEG de daha az yavaş aktiviteye neden olabilir. Bu çalışma antipsikotik ilaçlarin dikkatli kullanılması gerektiğini gösteriyor
Anahtar Kelime: Konular:
Rat modelinde tipik ve atipik antipsikotik ilaçların beyin elektriksel aktivitesi üzerine etkileri
Öz: Objective: Antipsychotic drugs are known to have strong effect on the bioelectric activity in the brain. However, some studies addressing the changes on electroencephalography (EEG) caused by typical and atypical antipsychotic drugs are conflicting. We aimed to compare the effects of typical and atypical antipsychotics on the electrical activity in the brain via EEG recordings in a rat model.Methods: Thirty-two Sprague Dawley adult male rats were used in the study. The rats were divided into five groups, randomly (n=7, for each group). The first group was used as control group and administered 1 ml/kg saline intraperitoneally (IP). Haloperidol (1 mg/kg) (group 2), chlorpromazine (5 mg/kg) (group 3), olanzapine (1 mg/kg) (group 4), ziprasidone (1 mg/ kg) (group 5) were injected IP for five consecutive days. Then, EEG recordings of each group were taken for 30 minutes.Results: The percentages of delta and theta waves in haloperidol, chlorpromazine, olanzapine and ziprasidone groups were found to have a highly significant difference compared with the saline administration group (p<0.001). The theta waves in the olanzapine and ziprasidone groups were increased compared with haloperidol and chlorpromazine groups (p<0.05).Conclusion: The typical and atypical antipsychotic drugs may be risk factor for EEG abnormalities. This study shows that antipsychotic drugs should be used with caution. J Clin Exp Invest 2013; 4 (3): 279-284
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | ERBAS O, Yılmaz M (2013). The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model. , 279 - 284. |
| Chicago | ERBAS Oytun,Yılmaz Mustafa The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model. (2013): 279 - 284. |
| MLA | ERBAS Oytun,Yılmaz Mustafa The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model. , 2013, ss.279 - 284. |
| AMA | ERBAS O,Yılmaz M The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model. . 2013; 279 - 284. |
| Vancouver | ERBAS O,Yılmaz M The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model. . 2013; 279 - 284. |
| IEEE | ERBAS O,Yılmaz M "The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model." , ss.279 - 284, 2013. |
| ISNAD | ERBAS, Oytun - Yılmaz, Mustafa. "The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model". (2013), 279-284. |
| APA | ERBAS O, Yılmaz M (2013). The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model. Journal of Clinical and Experimental Investigations, 4(3), 279 - 284. |
| Chicago | ERBAS Oytun,Yılmaz Mustafa The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model. Journal of Clinical and Experimental Investigations 4, no.3 (2013): 279 - 284. |
| MLA | ERBAS Oytun,Yılmaz Mustafa The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model. Journal of Clinical and Experimental Investigations, vol.4, no.3, 2013, ss.279 - 284. |
| AMA | ERBAS O,Yılmaz M The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model. Journal of Clinical and Experimental Investigations. 2013; 4(3): 279 - 284. |
| Vancouver | ERBAS O,Yılmaz M The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model. Journal of Clinical and Experimental Investigations. 2013; 4(3): 279 - 284. |
| IEEE | ERBAS O,Yılmaz M "The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model." Journal of Clinical and Experimental Investigations, 4, ss.279 - 284, 2013. |
| ISNAD | ERBAS, Oytun - Yılmaz, Mustafa. "The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model". Journal of Clinical and Experimental Investigations 4/3 (2013), 279-284. |
