DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER

Hatice GÜNEŞ, (Biyoloji Bölümü, Fen Fakültesi, Muğla Sıtkı Koçman Üniversitesi, Muğla, Türkiye)
Müjgan KESİK OKTAY (Biyoloji Bölümü, Fen Fakültesi, Muğla Sıtkı Koçman Üniversitesi, Muğla, Türkiye)
Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji
14 0
Yıl: 2017 Cilt: 6 Sayı: 2 Sayfa Aralığı: 103 - 113 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER

Öz:
Bacillus thuringiensis doğada geniş yayılım gösteren, gram pozitif ve spor oluşturan bir bakteridir. Sporulasyon evresinde, sporlarla birlikte birçok böcek çeşidine karşı insektisit etki gösteren kristal proteinleri de üretir. İnsektisidal kristal proteinler Cry ve Cyt proteinler olup; aktivitelerini duyarlı böceklerin orta barsak membranlarında bulunan reseptöre bağlanarak gösterirler. Bu reseptör bağlantılı özgül aktivitelerinden dolayı zirai mücadelede önemlidirler. Daha sonraları, insektisit olanlara göre doğada daha geniş dağılım gösteren insektisit olmayan kristal proteinler üzerindeki çalışmalar yeni bir protein sınıfı olan parasporinleri ortaya çıkarmıştır. Parasporinler ayrıcalıklı olarak kanser hücrelerine karşı sitotoksik etki gösterirken normal hücrelere etki etmez ve hemolitik etki göstermez. Şimdiye kadar altı parasporin ailesi tanımlanmış olup toplamda 19 alt grup bilinmektedir. Parasporinler de insektisidal kristal proteinlere benzer şekilde reseptör bağlantılı etki gösterdiğinden kanser tedavisiyle ilgili çalışmalarda yeni bir araştırma alanının ortaya çıkmasını sağlamıştır. Bu derlemede; parasporinlerin keşfi, özellikleri, çeşitleri ve etki mekanizmaları hakkında yapılmış olan çalışmalar özetle anlatılmıştır
Anahtar Kelime:

PARASPORINS AS A NATURAL ANTI-CANCER PROTEIN

Öz:
Bacillus thuringiensis (Bt) is a gram positive and spore forming bacterium that shows a wide distribution in the nature. During the sporulation phase, it produces insecticidal crystal proteins along with spores. These insecticidal proteins are called Cry and Cyt proteins and have an activity when binding to spesific receptor located on the plasma membrane of mid-gut epithelial cells of susceptible insects. This receptor mediated spesific activity makes Bt important in agricultural control of insects. Afterwards, research on non-insecticidal proteins that have a wider distribution in nature than insecticidal ones revealed a new protein class called parasporin. Parasporins are capable of discriminately killing cancer cells while does not show cytotoxic and hemolytic activity against normal cells. So far, six parasporin families have been defined and a total of 19 sub-group is known. Because parasporins have a similar spesific-receptor binding effect with insecticidal crystal proteins, they had led to emergence of a new research field related to cancer treatment. This study reviewed the discovery of parasporins, their characteristics, varieties and their mechanisms of action on cancer cells
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
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APA güneş h, KESİK OKTAY M (2017). DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER. , 103 - 113.
Chicago güneş hatice,KESİK OKTAY MÜJGAN DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER. (2017): 103 - 113.
MLA güneş hatice,KESİK OKTAY MÜJGAN DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER. , 2017, ss.103 - 113.
AMA güneş h,KESİK OKTAY M DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER. . 2017; 103 - 113.
Vancouver güneş h,KESİK OKTAY M DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER. . 2017; 103 - 113.
IEEE güneş h,KESİK OKTAY M "DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER." , ss.103 - 113, 2017.
ISNAD güneş, hatice - KESİK OKTAY, MÜJGAN. "DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER". (2017), 103-113.
APA güneş h, KESİK OKTAY M (2017). DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji, 6(2), 103 - 113.
Chicago güneş hatice,KESİK OKTAY MÜJGAN DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji 6, no.2 (2017): 103 - 113.
MLA güneş hatice,KESİK OKTAY MÜJGAN DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji, vol.6, no.2, 2017, ss.103 - 113.
AMA güneş h,KESİK OKTAY M DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji. 2017; 6(2): 103 - 113.
Vancouver güneş h,KESİK OKTAY M DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji. 2017; 6(2): 103 - 113.
IEEE güneş h,KESİK OKTAY M "DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER." Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji, 6, ss.103 - 113, 2017.
ISNAD güneş, hatice - KESİK OKTAY, MÜJGAN. "DOĞAL BİR ANTİ-KANSER PROTEİN OLAN PARASPORİNLER". Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji 6/2 (2017), 103-113.
Sayfa Oluşturulma Tarihi
23-04-2024 5:9

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