OKÜLT HEPATİT B VİRUS ENFEKSİYONU: MOLEKÜLER MEKANİZMALAR VE KLİNİK ÖNEMİ

Bülent ÇAKAL (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)
İstanbul Tıp Fakültesi Dergisi
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Yıl: 2017 Cilt: 80 Sayı: 2 Sayfa Aralığı: 71 - 81 Metin Dili: Türkçe İndeks Tarihi: 13-12-2018

OKÜLT HEPATİT B VİRUS ENFEKSİYONU: MOLEKÜLER MEKANİZMALAR VE KLİNİK ÖNEMİ

Öz:
Okült Hepatitis B Virüs (HBV) infeksiyonu (OBİ) serum HBV DNA statüsü dikkate alınmaksızın mevcut serolojiktestler ile HBV yüzey antijeni (HBsAg) negatif tespit edilen bireylerin karaciğerin de HBV genomunun uzun sürelipersistan varlığı olarak tanımlanır. OBİ virüse ve infekte bireye ait faktörler ile çevresel faktörlerin zemininde gelişengenetik, epigenetik ve immünolojik mekanizmaların karşılıklı etkileşimi ile şekillenen, HBV infeksiyonunun doğalseyri içerisinde yer alan muhtemel safhalarından biri olarak kabul edilir. OBİ klinik açıdan; okült virüsün kantransfüzyonu, doğum, hemodiyaliz ve ortotopik karaciğer gibi organ nakli yolu ile bulaşını takiben alıcıda tipik yeniHBV infeksiyonuna neden olabilmesi, immünsüpresyon koşullarında OBİ reaktivasyonu ve takiben HBV ilişkili (akutve fulminan hepatit) karaciğer hastalıkları, kronik karaciğer hastalıklarının (KKH) progresyonu üzerine etkisi ileözellikle hepatoselüler karsinoma (HSK) için artan bir risk faktörü olduğu yönünde hipotez uyarınca yoğun bir tartışmave araştırma konusudur. Buna karşın gerek HBV infeksiyonunun bu özgün formuna neden olan gerekse ilişkili olduğukaraciğer hastalıklarının patogenezinde rol alan moleküler mekanizmalar henüz tam olarak aydınlatılamamıştır. Buderlemede OBİ’nin klinik önemi, epidemiyolojik özellikleri ve laboratuar tanısına yönelik bilimsel literatürün gözdengeçirilmesi amaçlanmıştır.
Anahtar Kelime:

Konular: Mikrobiyoloji Enfeksiyon Hastalıkları

OCCULT HEPATITIS B VIRUS INFECTION: MOLECULAR MECHANISMS AND CLINICAL SIGNIFICANCE

Öz:
Occult Hepatitis B Virus (HBV) infection (OBI) is defined as the long-lasting persistence of HBV genomes in the hepatocytes of individuals testing negative for HBV surface antigen (HBsAg) by currently available assays and usually for serum HBV DNA. OBI is considered as the possible phase in the natural history of chronic HBV infection that the host’s immune surveillance and epigenetic mechanisms are likely involved. Clinical impact of OB is that it can be transmitted (i.e., through blood transfusion, by liver organ transplantation, hemodialysis and parturition) causing classic forms of hepatitis B in newly infected individuals. The development of an immunosuppressive status may induce OBI reactivation and development of acute and often severe hepatitis. OBI can favor the progression of liver fibrosis. Also OBİ infection has been hypothesized to be a significant risk factor contributing to the progression of chronic liver diseases (CLD) with increased risk for hepatocellular carcinoma (HCC) which may lead to an increased progression of liver diseases. Although OBI is considered a phase in the natural history of HBV, the molecular mechanisms leading to its occurrence and its contribution to HCC development are yet poorly understood. In this review, it is aimed to examine clinical importance, epidemiological aspects and laboratory diagnosis of OBI in recent literature.
Anahtar Kelime:

Konular: Mikrobiyoloji Enfeksiyon Hastalıkları
Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
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APA Cakal B (2017). OKÜLT HEPATİT B VİRUS ENFEKSİYONU: MOLEKÜLER MEKANİZMALAR VE KLİNİK ÖNEMİ. , 71 - 81.
Chicago Cakal Bulent OKÜLT HEPATİT B VİRUS ENFEKSİYONU: MOLEKÜLER MEKANİZMALAR VE KLİNİK ÖNEMİ. (2017): 71 - 81.
MLA Cakal Bulent OKÜLT HEPATİT B VİRUS ENFEKSİYONU: MOLEKÜLER MEKANİZMALAR VE KLİNİK ÖNEMİ. , 2017, ss.71 - 81.
AMA Cakal B OKÜLT HEPATİT B VİRUS ENFEKSİYONU: MOLEKÜLER MEKANİZMALAR VE KLİNİK ÖNEMİ. . 2017; 71 - 81.
Vancouver Cakal B OKÜLT HEPATİT B VİRUS ENFEKSİYONU: MOLEKÜLER MEKANİZMALAR VE KLİNİK ÖNEMİ. . 2017; 71 - 81.
IEEE Cakal B "OKÜLT HEPATİT B VİRUS ENFEKSİYONU: MOLEKÜLER MEKANİZMALAR VE KLİNİK ÖNEMİ." , ss.71 - 81, 2017.
ISNAD Cakal, Bulent. "OKÜLT HEPATİT B VİRUS ENFEKSİYONU: MOLEKÜLER MEKANİZMALAR VE KLİNİK ÖNEMİ". (2017), 71-81.
APA Cakal B (2017). OKÜLT HEPATİT B VİRUS ENFEKSİYONU: MOLEKÜLER MEKANİZMALAR VE KLİNİK ÖNEMİ. İstanbul Tıp Fakültesi Dergisi, 80(2), 71 - 81.
Chicago Cakal Bulent OKÜLT HEPATİT B VİRUS ENFEKSİYONU: MOLEKÜLER MEKANİZMALAR VE KLİNİK ÖNEMİ. İstanbul Tıp Fakültesi Dergisi 80, no.2 (2017): 71 - 81.
MLA Cakal Bulent OKÜLT HEPATİT B VİRUS ENFEKSİYONU: MOLEKÜLER MEKANİZMALAR VE KLİNİK ÖNEMİ. İstanbul Tıp Fakültesi Dergisi, vol.80, no.2, 2017, ss.71 - 81.
AMA Cakal B OKÜLT HEPATİT B VİRUS ENFEKSİYONU: MOLEKÜLER MEKANİZMALAR VE KLİNİK ÖNEMİ. İstanbul Tıp Fakültesi Dergisi. 2017; 80(2): 71 - 81.
Vancouver Cakal B OKÜLT HEPATİT B VİRUS ENFEKSİYONU: MOLEKÜLER MEKANİZMALAR VE KLİNİK ÖNEMİ. İstanbul Tıp Fakültesi Dergisi. 2017; 80(2): 71 - 81.
IEEE Cakal B "OKÜLT HEPATİT B VİRUS ENFEKSİYONU: MOLEKÜLER MEKANİZMALAR VE KLİNİK ÖNEMİ." İstanbul Tıp Fakültesi Dergisi, 80, ss.71 - 81, 2017.
ISNAD Cakal, Bulent. "OKÜLT HEPATİT B VİRUS ENFEKSİYONU: MOLEKÜLER MEKANİZMALAR VE KLİNİK ÖNEMİ". İstanbul Tıp Fakültesi Dergisi 80/2 (2017), 71-81.
Sayfa Oluşturulma Tarihi
23-04-2024 7:0

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