In vitro anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr., namely as Earthstar fungus

Ugur, Aysel; ALLI, HAKAN; BAYGAR, Tuba; Sarac, Nurdan

In vitro anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr., namely as Earthstar fungus

Nurdan SARAÇ, (Department of Biology, Faculty of Science, Mugla Sitki Kocman University, 48000 Mugla, Turkey)

Hakan ALLI, (Department of Biology, Faculty of Science, Mugla Sitki Kocman University, 48000 Mugla, Turkey)

Tuba BAYGAR, (Material Research Laboratory, Research Laboratories Center, Mugla Sitki Kocman University, 48000 Mugla, Turkey)

Aysel UĞUR (Section of Medical Microbiology, Department of Basic Sciences, Faculty of Dentistry, Gazi University, Ankara, Turkey)

International Journal of Secondary Metabolite

4 0

Yıl: 2019 Cilt: 6 Sayı: 1 Sayfa Aralığı: 1 - 9 Metin Dili: İngilizce İndeks Tarihi: 29-05-2019

In vitro anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr., namely as Earthstar fungus

Öz:

Mushrooms have great potential to be used as food and pharmaceutical sources. Most of the non-edible mushrooms contain biologically active metabolites that are functional for modern medicinal applications. Within the present study, anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr. (Syn. Geastrum sessile (Sowerby) Pouzar), a mushroom naturally grown in Turkey, were investigated. The in vitro anticoagulant activity of the ethanolic extract obtained with a soxhlet apparatus determined by activated partial thromboplastin time (APTT) and prothrombin time (PT) assays using commercial reagents. The antiinflammatory activity of the extract was determined by lipoxygenase inhibition assay. When compared with the negative control DMSO, G. fimbriatum extract exhibited significant anticoagulant effects in the APTT test that evaluates the intrinsic coagulation pathway. The ethanolic extract found to prolong the coagulation time. However, no inhibition was observed in the PT test which evaluates the extrinsic coagulation pathway, The extract showed 12.92% inhibition on the lipoxygenase enzyme activity. Overall, G. fimbriatum ethanolic extract exhibited potent antiinflammatory activity besides being a potential source of anticoagulant. Further analysis is required to evaluate the medical use of Geastrum mushrooms from a pharmaceutical point of view.

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Konular: Biyoloji

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APA	Sarac N, ALLI H, BAYGAR T, Ugur A (2019). In vitro anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr., namely as Earthstar fungus. , 1 - 9.
Chicago	Sarac Nurdan,ALLI HAKAN,BAYGAR Tuba,Ugur Aysel In vitro anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr., namely as Earthstar fungus. (2019): 1 - 9.
MLA	Sarac Nurdan,ALLI HAKAN,BAYGAR Tuba,Ugur Aysel In vitro anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr., namely as Earthstar fungus. , 2019, ss.1 - 9.
AMA	Sarac N,ALLI H,BAYGAR T,Ugur A In vitro anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr., namely as Earthstar fungus. . 2019; 1 - 9.
Vancouver	Sarac N,ALLI H,BAYGAR T,Ugur A In vitro anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr., namely as Earthstar fungus. . 2019; 1 - 9.
IEEE	Sarac N,ALLI H,BAYGAR T,Ugur A "In vitro anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr., namely as Earthstar fungus." , ss.1 - 9, 2019.
ISNAD	Sarac, Nurdan vd. "In vitro anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr., namely as Earthstar fungus". (2019), 1-9.

APA	Sarac N, ALLI H, BAYGAR T, Ugur A (2019). In vitro anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr., namely as Earthstar fungus. International Journal of Secondary Metabolite, 6(1), 1 - 9.
Chicago	Sarac Nurdan,ALLI HAKAN,BAYGAR Tuba,Ugur Aysel In vitro anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr., namely as Earthstar fungus. International Journal of Secondary Metabolite 6, no.1 (2019): 1 - 9.
MLA	Sarac Nurdan,ALLI HAKAN,BAYGAR Tuba,Ugur Aysel In vitro anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr., namely as Earthstar fungus. International Journal of Secondary Metabolite, vol.6, no.1, 2019, ss.1 - 9.
AMA	Sarac N,ALLI H,BAYGAR T,Ugur A In vitro anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr., namely as Earthstar fungus. International Journal of Secondary Metabolite. 2019; 6(1): 1 - 9.
Vancouver	Sarac N,ALLI H,BAYGAR T,Ugur A In vitro anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr., namely as Earthstar fungus. International Journal of Secondary Metabolite. 2019; 6(1): 1 - 9.
IEEE	Sarac N,ALLI H,BAYGAR T,Ugur A "In vitro anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr., namely as Earthstar fungus." International Journal of Secondary Metabolite, 6, ss.1 - 9, 2019.
ISNAD	Sarac, Nurdan vd. "In vitro anticoagulant and antiinflammatory activities of Geastrum fimbriatum Fr., namely as Earthstar fungus". International Journal of Secondary Metabolite 6/1 (2019), 1-9.