Psoriasis is a common and serious systemic inflammatory disease. The purpose of this study is to research the relationship between bisphenol A, betatrophin, urocortin 3 and vitamin D levels in patients with psoriasis. Sixty patients with psoriasis (mean age, 34.1±9.6 years) and twenty six age and gender-matched healthy individuals (mean age, 35.5 ±10.5 years) were included in this study. Bisphenol A, betatrophin, urocortin 3 and vitamin D levels were assessed by using enzyme-linked immunosorbent assay in all participants. Serum levels of bisphenol A were detected using UPLC-ESI-MS/MS. In psoriasis patients, the median bisphenol A serum level was 0.537 ng/mL (range 1.1), and significantly higher compared to controls (median 0.2 range 0.9 ng/mL) (p<0.001). The median serum level of betatrophin was 270 ng/mL (range 5834.7 ng/mL) in patients with psoriasis, and significantly different from the control group (median 198.7, range 198.2). The median serum level of urocortin 3 was 63.3 (range 129.1) in patients with psoriasis, and it was not significantly different compared to control group (median 27 range 537.9). The median serum level of vitamin D was 23.6 (range 377), and it was significantly lower than the control group (median 156.8 range 247.1) (p<0.001). A positive correlation was found between serum bisphenol A and PASI scores in patients with psoriasis (p<0.001, r=0.878). Furthermore, urocortin positively correlated with the duration of illness (p<0.001, r= 0.557). In ROC analysis, bisphenol A values greater than 0.764 were predicted psoriasis with 88.3% sensitivity and 61.5% specificity. Betatrophin levels greater than 0.819 were predicted psoriasis with 80% sensitivity and 69.2% specificity. We have determined a relationship between bisphenol A, betatrophin and vitamin D levels in the inflammatory process in the pathophysiology of psoriasis. Bisphenol A and betatrophin may be predictive markers for presence of psoriasis and the disease severity.