Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis
Yıl: 2019 Cilt: 36 Sayı: 3 Sayfa Aralığı: 174 - 178 Metin Dili: İngilizce DOI: 10.4274/balkanmedj.galenos.2018.2017.1034 İndeks Tarihi: 20-01-2020
Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis
Öz: Background: It is well known that axonal degeneration plays a role in disability in patients with multiple sclerosis, and synaptopathy has recently become an important issue.Aims: To investigate the possible roles of selected synaptic and presynaptic membrane protein genetic polymorphisms (VAMP2, SNAP-25, synaptotagmin, and syntaxin 1A) in patients with multiple sclerosis.Study Design: Case-control study.Methods: A total of 123 patients with multiple sclerosis and 192 healthy controls were included. The functional polymorphisms of specific SNARE complex proteins (VAMP2, synaptotagmin XI, syntaxin 1A, and SNAP-25) were analyzed by polymerase chain reaction.Results: Significant differences were detected in the genotype and allele distribution of 26-bp Ins/Del polymorphisms of VAMP2 between patients with multiple sclerosis and control subjects; Del/Del genotype and Del allele of VAMP2 were more frequent in patients with multiple sclerosis (p=0.011 and p=0.004, respectively). Similarly, Ddel polymorphism of SNAP-25 gene C/C genotype (p=0.059), syntaxin 1A T/C and C/C genotypes (p=0.005), and synaptotagmin XI gene C allele (p=0.001) were observed more frequently in patients with multiple sclerosis. CC, syntaxin rs1569061 1A gene for 33-bp promoter region TC haplotypes, and synaptotagmin XI gene were found to be associated with an increased risk for multiple sclerosis (p=0.012). Similarly, GC haplotype for rs3746544 of SNAP-25 gene and rs1051312 of SNAP-25 gene were associated with an increased risk for multiple sclerosis (p=0.022).Conclusion: Genetic polymorphisms of SNARE complex proteins, which have critical roles in synaptic structure and communication, may play a role in the development of multiple sclerosis.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Yalın O, GÖKDOĞAN EDGÜNLÜ T, KARAKAŞ ÇELİK S, EMRE U, GÜNEŞ T, ERDAL Y, EROĞLU ÜNAL A (2019). Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis. , 174 - 178. 10.4274/balkanmedj.galenos.2018.2017.1034 |
| Chicago | Yalın Osman Özgür,GÖKDOĞAN EDGÜNLÜ Tuba,KARAKAŞ ÇELİK Sevim,EMRE Ufuk,GÜNEŞ TAŞKIN,ERDAL Yuksel,EROĞLU ÜNAL Aysun Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis. (2019): 174 - 178. 10.4274/balkanmedj.galenos.2018.2017.1034 |
| MLA | Yalın Osman Özgür,GÖKDOĞAN EDGÜNLÜ Tuba,KARAKAŞ ÇELİK Sevim,EMRE Ufuk,GÜNEŞ TAŞKIN,ERDAL Yuksel,EROĞLU ÜNAL Aysun Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis. , 2019, ss.174 - 178. 10.4274/balkanmedj.galenos.2018.2017.1034 |
| AMA | Yalın O,GÖKDOĞAN EDGÜNLÜ T,KARAKAŞ ÇELİK S,EMRE U,GÜNEŞ T,ERDAL Y,EROĞLU ÜNAL A Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis. . 2019; 174 - 178. 10.4274/balkanmedj.galenos.2018.2017.1034 |
| Vancouver | Yalın O,GÖKDOĞAN EDGÜNLÜ T,KARAKAŞ ÇELİK S,EMRE U,GÜNEŞ T,ERDAL Y,EROĞLU ÜNAL A Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis. . 2019; 174 - 178. 10.4274/balkanmedj.galenos.2018.2017.1034 |
| IEEE | Yalın O,GÖKDOĞAN EDGÜNLÜ T,KARAKAŞ ÇELİK S,EMRE U,GÜNEŞ T,ERDAL Y,EROĞLU ÜNAL A "Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis." , ss.174 - 178, 2019. 10.4274/balkanmedj.galenos.2018.2017.1034 |
| ISNAD | Yalın, Osman Özgür vd. "Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis". (2019), 174-178. https://doi.org/10.4274/balkanmedj.galenos.2018.2017.1034 |
| APA | Yalın O, GÖKDOĞAN EDGÜNLÜ T, KARAKAŞ ÇELİK S, EMRE U, GÜNEŞ T, ERDAL Y, EROĞLU ÜNAL A (2019). Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis. Balkan Medical Journal, 36(3), 174 - 178. 10.4274/balkanmedj.galenos.2018.2017.1034 |
| Chicago | Yalın Osman Özgür,GÖKDOĞAN EDGÜNLÜ Tuba,KARAKAŞ ÇELİK Sevim,EMRE Ufuk,GÜNEŞ TAŞKIN,ERDAL Yuksel,EROĞLU ÜNAL Aysun Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis. Balkan Medical Journal 36, no.3 (2019): 174 - 178. 10.4274/balkanmedj.galenos.2018.2017.1034 |
| MLA | Yalın Osman Özgür,GÖKDOĞAN EDGÜNLÜ Tuba,KARAKAŞ ÇELİK Sevim,EMRE Ufuk,GÜNEŞ TAŞKIN,ERDAL Yuksel,EROĞLU ÜNAL Aysun Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis. Balkan Medical Journal, vol.36, no.3, 2019, ss.174 - 178. 10.4274/balkanmedj.galenos.2018.2017.1034 |
| AMA | Yalın O,GÖKDOĞAN EDGÜNLÜ T,KARAKAŞ ÇELİK S,EMRE U,GÜNEŞ T,ERDAL Y,EROĞLU ÜNAL A Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis. Balkan Medical Journal. 2019; 36(3): 174 - 178. 10.4274/balkanmedj.galenos.2018.2017.1034 |
| Vancouver | Yalın O,GÖKDOĞAN EDGÜNLÜ T,KARAKAŞ ÇELİK S,EMRE U,GÜNEŞ T,ERDAL Y,EROĞLU ÜNAL A Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis. Balkan Medical Journal. 2019; 36(3): 174 - 178. 10.4274/balkanmedj.galenos.2018.2017.1034 |
| IEEE | Yalın O,GÖKDOĞAN EDGÜNLÜ T,KARAKAŞ ÇELİK S,EMRE U,GÜNEŞ T,ERDAL Y,EROĞLU ÜNAL A "Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis." Balkan Medical Journal, 36, ss.174 - 178, 2019. 10.4274/balkanmedj.galenos.2018.2017.1034 |
| ISNAD | Yalın, Osman Özgür vd. "Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis". Balkan Medical Journal 36/3 (2019), 174-178. https://doi.org/10.4274/balkanmedj.galenos.2018.2017.1034 |
