The Protective Role of Resveratrol on Diabetic Cardiomyopathy in Streptozocin Induced Diabetic Rats
Yıl: 2019 Cilt: 7 Sayı: 2 Sayfa Aralığı: 84 - 88 Metin Dili: İngilizce DOI: 10.32596/ejcm.galenos.2019.00023 İndeks Tarihi: 25-02-2020
The Protective Role of Resveratrol on Diabetic Cardiomyopathy in Streptozocin Induced Diabetic Rats
Öz: Objectives: We aimed to investigate the effect ofresveratrol on diabetic cardiomyopathy in streptozocininduced diabetic rats.Materials and Methods: Rats were injected withstreptozocin to establish diabetes model. After fourweeks, heart tissues were collected for histopathologicalexamination and immunoexpression of nitric oxidesynthases-2 (NOS-2) and transforming growth factor-β1(TGF-β1). Lipid peroxidation was evaluated.Results: In diabetic rats, cardiac muscle cell thickness(hypertrophy), TGF-β1 and NOS-2 expression wereincreased significantly when compared to control group.Administration of resveratrol in diabetic rats causes asignificant reduction both in cardiac muscle cell thickness,TGF-β1 and NOS-2 expression in these rats.Blood glucose levels were significantly increased in diabeticrats expectedly, but there was no important differencebetween diabetic rats and resveratrol administrated diabeticrats in terms of blood glucose levels.Conclusion: We showed protective effects of resveratrolon dilated cardiomyopathy on diabetic rats by reducingoxidative stress. As the prevalence of diabetes mellitusis increasing, resveratrol supplementation could helppreventing diabetic cardiomyopathy.
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| APA | Canbolat I, ÇAVUŞOĞLU T, Yigitturk G, ATEŞ U, ERBAS O (2019). The Protective Role of Resveratrol on Diabetic Cardiomyopathy in Streptozocin Induced Diabetic Rats. , 84 - 88. 10.32596/ejcm.galenos.2019.00023 |
| Chicago | Canbolat Ismail Polat,ÇAVUŞOĞLU Türker,Yigitturk Gurkan,ATEŞ Utku,ERBAS Oytun The Protective Role of Resveratrol on Diabetic Cardiomyopathy in Streptozocin Induced Diabetic Rats. (2019): 84 - 88. 10.32596/ejcm.galenos.2019.00023 |
| MLA | Canbolat Ismail Polat,ÇAVUŞOĞLU Türker,Yigitturk Gurkan,ATEŞ Utku,ERBAS Oytun The Protective Role of Resveratrol on Diabetic Cardiomyopathy in Streptozocin Induced Diabetic Rats. , 2019, ss.84 - 88. 10.32596/ejcm.galenos.2019.00023 |
| AMA | Canbolat I,ÇAVUŞOĞLU T,Yigitturk G,ATEŞ U,ERBAS O The Protective Role of Resveratrol on Diabetic Cardiomyopathy in Streptozocin Induced Diabetic Rats. . 2019; 84 - 88. 10.32596/ejcm.galenos.2019.00023 |
| Vancouver | Canbolat I,ÇAVUŞOĞLU T,Yigitturk G,ATEŞ U,ERBAS O The Protective Role of Resveratrol on Diabetic Cardiomyopathy in Streptozocin Induced Diabetic Rats. . 2019; 84 - 88. 10.32596/ejcm.galenos.2019.00023 |
| IEEE | Canbolat I,ÇAVUŞOĞLU T,Yigitturk G,ATEŞ U,ERBAS O "The Protective Role of Resveratrol on Diabetic Cardiomyopathy in Streptozocin Induced Diabetic Rats." , ss.84 - 88, 2019. 10.32596/ejcm.galenos.2019.00023 |
| ISNAD | Canbolat, Ismail Polat vd. "The Protective Role of Resveratrol on Diabetic Cardiomyopathy in Streptozocin Induced Diabetic Rats". (2019), 84-88. https://doi.org/10.32596/ejcm.galenos.2019.00023 |
| APA | Canbolat I, ÇAVUŞOĞLU T, Yigitturk G, ATEŞ U, ERBAS O (2019). The Protective Role of Resveratrol on Diabetic Cardiomyopathy in Streptozocin Induced Diabetic Rats. E Journal of Cardiovascular Medicine, 7(2), 84 - 88. 10.32596/ejcm.galenos.2019.00023 |
| Chicago | Canbolat Ismail Polat,ÇAVUŞOĞLU Türker,Yigitturk Gurkan,ATEŞ Utku,ERBAS Oytun The Protective Role of Resveratrol on Diabetic Cardiomyopathy in Streptozocin Induced Diabetic Rats. E Journal of Cardiovascular Medicine 7, no.2 (2019): 84 - 88. 10.32596/ejcm.galenos.2019.00023 |
| MLA | Canbolat Ismail Polat,ÇAVUŞOĞLU Türker,Yigitturk Gurkan,ATEŞ Utku,ERBAS Oytun The Protective Role of Resveratrol on Diabetic Cardiomyopathy in Streptozocin Induced Diabetic Rats. E Journal of Cardiovascular Medicine, vol.7, no.2, 2019, ss.84 - 88. 10.32596/ejcm.galenos.2019.00023 |
| AMA | Canbolat I,ÇAVUŞOĞLU T,Yigitturk G,ATEŞ U,ERBAS O The Protective Role of Resveratrol on Diabetic Cardiomyopathy in Streptozocin Induced Diabetic Rats. E Journal of Cardiovascular Medicine. 2019; 7(2): 84 - 88. 10.32596/ejcm.galenos.2019.00023 |
| Vancouver | Canbolat I,ÇAVUŞOĞLU T,Yigitturk G,ATEŞ U,ERBAS O The Protective Role of Resveratrol on Diabetic Cardiomyopathy in Streptozocin Induced Diabetic Rats. E Journal of Cardiovascular Medicine. 2019; 7(2): 84 - 88. 10.32596/ejcm.galenos.2019.00023 |
| IEEE | Canbolat I,ÇAVUŞOĞLU T,Yigitturk G,ATEŞ U,ERBAS O "The Protective Role of Resveratrol on Diabetic Cardiomyopathy in Streptozocin Induced Diabetic Rats." E Journal of Cardiovascular Medicine, 7, ss.84 - 88, 2019. 10.32596/ejcm.galenos.2019.00023 |
| ISNAD | Canbolat, Ismail Polat vd. "The Protective Role of Resveratrol on Diabetic Cardiomyopathy in Streptozocin Induced Diabetic Rats". E Journal of Cardiovascular Medicine 7/2 (2019), 84-88. https://doi.org/10.32596/ejcm.galenos.2019.00023 |
