Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia

metin aksu, nalan; ÇINAR, Neşe; Ucar, Fatma; Usman, Aydan; YAZGAN AKSOY, Duygu; akkaş, meltem; YILDIZ, Bülent Okan

doi:10.3906/sag-1903-35

Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia

Nalan Metin AKSU, (Hacettepe Üniversitesi)

Duygu YAZGAN AKSOY, (Acıbadem Mehmet Aydınlar Üniversitesi)

Meltem AKKAŞ, (Hacettepe Üniversitesi)

Neşe ÇINAR, (Muğla Sıtkı Koçman Üniversitesi)

Fatma UÇAR, (Sağlık Bakanlığı)

Bülent Okan YILDIZ, (Hacettepe Üniversitesi)

Aydan USMAN (Hacettepe Üniversitesi)

Turkish Journal of Medical Sciences

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Yıl: 2020 Cilt: 50 Sayı: 2 Sayfa Aralığı: 312 - 315 Metin Dili: İngilizce DOI: 10.3906/sag-1903-35 İndeks Tarihi: 28-04-2020

Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia

Öz:

Background/aim: Acute hyperglycemia is generally a frequently encountered condition in the emergency department (ED), becauseit is seen as a complication of diabetes mellitus (DM). In this study, we aimed to detect the change in adiponectin levels during acutehyperglycemic states and after normalization of blood glucose with insulin treatment.Materials and methods: Forty-eight patients over the age of 18 years who were admitted to the ED with acute hyperglycemia wereincluded in the study. Serum samples were taken from patients on admission and 6 h after the normalization of blood glucose withinsulin treatment, and adiponectin levels were measured in both samples.Results: There were 21 female and 27 male patients with a median age of 58.7 ± 18 years. All patients’ blood glucose levels werenormalized with insulin treatment according to international recommendations. Serum adiponectin levels decreased significantly afterthe normalization of blood glucose in the whole group. Adiponectin levels decreased from 28.9 ± 16.5 to 12.1 ± 10.9 μg/mL (P < 0.0001)in the whole group. This decrease was independent of diabetes type and body mass index.Conclusion: Normalization of blood glucose in patients with hyperglycemia caused a decrease in adiponectin levels, independentof diabetes type and/or body weight in an acute emergency setting. Inhibited upregulation of adiponectin secretion and/or bluntedsuppressive effect of insulin due to hyperglycemia or exogenous insulin administration may have caused the decrease in adiponectinlevels.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Centers for Disease Control and Prevention. National Diabetes Statistics Report. Prevent Type 2 Diabetes. Atlanta, GA, USA: CDC; 2019..
2. Gupta T, Hudson M. Update on glucose management among noncritically ill patients hospitalized on medical and surgical wards. Journal of Endocrine Society 2017; 1 (4): 247-259. doi: 10.1210/js.2016-1055
3. Faraj M, Beauregard G, Tardif A, Loizon E, Godbout A et al. Regulation of leptin, adiponectin and acylation-stimulating protein by hyperinsulinaemia and hyperglycaemia in vivo in healthy lean young men. Diabetes & Metabolism 2008; 34 (4): 334-342.
4. Achari AE, Jain SK. Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction. International Journal of Molecular Sciences 2017; 18 (6): E1321. doi: 10.3390/ijms18061321
5. Frankenberg ADV, Reis AF, Gerchman F. Relationships between adiponectin levels, the metabolic syndrome, and type 2 diabetes: a literature review. Archives of Endocrinology and Metabolism 2017; 61 (6): 614-622.
6. Andersson DP, Laurencikiene J, Acosta JR, Rydén M, Arner P. Circulating and adipose levels of adipokines associated with insulin sensitivity in nonobese subjects with type 2 diabetes. Journal of Clinical Endocrinology and Metabolism 2016: 101 (10): 3765-3771.
7. Halberg N, Schraw TD, Wang ZV, Kim JY, Yi J et al. Systemic fate of the adipocyte-derived factor adiponectin. Diabetes 2009; 58 (9): 1961-1970.
8. Jaganathan R, Ravindran R, Dhanasekaran S. Emerging role of adipocytokines in type 2 diabetes as mediators of insulin resistance and cardiovascular disease. Canadian Journal of Diabetes 2018; 42 (4): 446-456.e1.
9. Wang Y, Meng RW, Kunutsor SK, Chowdhury R, Yuan JM. Plasma adiponectin levels and type 2 diabetes risk: a nested case-control study in a Chinese population and an updated meta-analysis. Scientific Reports 2018; 8 (1): 406.
10. Adiyaman SC, Ozer M, Saydam BO, Akinci B. The role of adiponectin in maintaining metabolic homeostasis. Current Diabetes Reviews 2020; 16 (2): 95-103. doi: 10.2174/1573399 815666190702155733
11. Perkins JM, Joy NG, Tate DB, Davis SN. Acute effects of hyperinsulinemia and hyperglycemia on vascular inflammatory biomarkers and endothelial function in overweight and obese humans. American Journal of Physiology, Endocrinology and Metabolism 2015; 309 (2): E168-176.
12. Aso Y, Terasawa T, Kato K, Jojima T, Suzuki K et al. The serum level of soluble CD26/dipeptidyl peptidase 4 increases in response to acute hyperglycemia after an oral glucose load in healthy subjects: association with high-molecular weight adiponectin and hepatic enzymes. Translational Research 2013; 162 (5): 309-316.
13. Ozeki N, Hara K, Yatsuka C, Nakano T, Matsumoto S et al. Serum high-molecular weight adiponectin decreases abruptly after an oral glucose load in subjects with normal glucose tolerance or impaired fasting glucose, but not those with impaired glucose tolerance or diabetes mellitus. Metabolism 2009; 58 (10): 1470-1476.
14. Koniari K, Tousoulis D, Antoniades C, Nikolopoulou A, Voltyrakis E et al. The effect of glucose loading on adiponectin levels in diabetes mellitus type 2. Implications for Endothelial Dysfunction. Journal of Disease Markers 2014; 1 (2): 6.
15. Siervo M, Corander M, Mander AP, Browning LM, Jebb SA. Acute effects of hyperglycaemia on asymmetric dimethylarginine (ADMA), adiponectin and inflammatory markers (IL-6, hs-CRP) in overweight and obese women with metabolic syndrome. British Journal of Biomedical Science 2010; 67 (4): 216-218.
16. Dullaart RPF, Riemens SC, Meinardi JR, Wolffenbuttel BHR, Sluiter WJ. Plasma adiponectin is modestly decreased during 24-hour insulin infusion but not after inhibition of lipolysis by Acipimox. Scandinavian Journal of Clinical Laboratory and Investigation 2005; 65 (6): 523-532.
17. Uchihashi K, Aoki S, Shigematsu M, Kamochi N, Sonoda E et al. Organotypic culture of human bone marrow adipose tissue. Pathology International 2010; 60 (4): 259-267.
18. Orlando A, Nava E, Giussani M, Genovesi S. Adiponectin and cardiovascular risk. From pathophysiology to clinic: focus on children and adolescents. International Journal of Molecular Sciences 2019; 20 (13): E3228. doi: 10.3390/ijms20133228
19. Ismail MM, Abdel Hamid TA, Ibrahim AA, Marzouk H. Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus. Archives of Medical Sciences 2017; 13 (4): 738-744.
20. Yazıcı D, Yavuz D, Öğünç AV, Şirikçi Ö, Toprak A et al. Serum adipokine levels in type 1 diabetic patients: association with carotid intima media thickness. Metabolic Syndrome and Related Disorders 2012; 10 (1): 26-31.
21. Ahlstrom P, Rai E, Chakma S, Cho HH, Rengasamy P et al. Adiponectin improves insulin sensitivity via activation of autophagic flux. Journal of Molecular Endocrinology 2017;59 (4): 339-350.
22. Ruan H, Dong LQ. Adiponectin signaling and function in insulin target tissues. Journal of Molecular Cell Biology 2016; 8 (2): 101-109.

APA	metin aksu n, YAZGAN AKSOY D, akkaş m, ÇINAR N, Ucar F, YILDIZ B, Usman A (2020). Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia. , 312 - 315. 10.3906/sag-1903-35
Chicago	metin aksu nalan,YAZGAN AKSOY Duygu,akkaş meltem,ÇINAR Neşe,Ucar Fatma,YILDIZ Bülent Okan,Usman Aydan Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia. (2020): 312 - 315. 10.3906/sag-1903-35
MLA	metin aksu nalan,YAZGAN AKSOY Duygu,akkaş meltem,ÇINAR Neşe,Ucar Fatma,YILDIZ Bülent Okan,Usman Aydan Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia. , 2020, ss.312 - 315. 10.3906/sag-1903-35
AMA	metin aksu n,YAZGAN AKSOY D,akkaş m,ÇINAR N,Ucar F,YILDIZ B,Usman A Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia. . 2020; 312 - 315. 10.3906/sag-1903-35
Vancouver	metin aksu n,YAZGAN AKSOY D,akkaş m,ÇINAR N,Ucar F,YILDIZ B,Usman A Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia. . 2020; 312 - 315. 10.3906/sag-1903-35
IEEE	metin aksu n,YAZGAN AKSOY D,akkaş m,ÇINAR N,Ucar F,YILDIZ B,Usman A "Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia." , ss.312 - 315, 2020. 10.3906/sag-1903-35
ISNAD	metin aksu, nalan vd. "Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia". (2020), 312-315. https://doi.org/10.3906/sag-1903-35

APA	metin aksu n, YAZGAN AKSOY D, akkaş m, ÇINAR N, Ucar F, YILDIZ B, Usman A (2020). Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia. Turkish Journal of Medical Sciences, 50(2), 312 - 315. 10.3906/sag-1903-35
Chicago	metin aksu nalan,YAZGAN AKSOY Duygu,akkaş meltem,ÇINAR Neşe,Ucar Fatma,YILDIZ Bülent Okan,Usman Aydan Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia. Turkish Journal of Medical Sciences 50, no.2 (2020): 312 - 315. 10.3906/sag-1903-35
MLA	metin aksu nalan,YAZGAN AKSOY Duygu,akkaş meltem,ÇINAR Neşe,Ucar Fatma,YILDIZ Bülent Okan,Usman Aydan Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia. Turkish Journal of Medical Sciences, vol.50, no.2, 2020, ss.312 - 315. 10.3906/sag-1903-35
AMA	metin aksu n,YAZGAN AKSOY D,akkaş m,ÇINAR N,Ucar F,YILDIZ B,Usman A Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia. Turkish Journal of Medical Sciences. 2020; 50(2): 312 - 315. 10.3906/sag-1903-35
Vancouver	metin aksu n,YAZGAN AKSOY D,akkaş m,ÇINAR N,Ucar F,YILDIZ B,Usman A Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia. Turkish Journal of Medical Sciences. 2020; 50(2): 312 - 315. 10.3906/sag-1903-35
IEEE	metin aksu n,YAZGAN AKSOY D,akkaş m,ÇINAR N,Ucar F,YILDIZ B,Usman A "Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia." Turkish Journal of Medical Sciences, 50, ss.312 - 315, 2020. 10.3906/sag-1903-35
ISNAD	metin aksu, nalan vd. "Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia". Turkish Journal of Medical Sciences 50/2 (2020), 312-315. https://doi.org/10.3906/sag-1903-35