Objective: Traumatic brain injury (TBI) is one of the leading causes that cognitive andbehavioral problems. Many pharmacological therapies reveal early neurochemical changes. TheCRS-R is a standardized neuro-behavioral evaluation tool comprising six organized subscales(auditory, visual, motor, oromotor–verbal, communication, and arousal). We hypothesized that,the effect of amantadine sulfate infusion treatment on conscious recovery and clinical improvement in patients with severe head injury in terms of CRS-R and clinical recovery. Material and Methods: Patients’ age, gender, days of hospitalization, pre-treatment andpost-treatment GCS, education level, day of amantadine sulfate, intubated or non-intubatedwhen he/she come to intensive care unit (ICU), recovery time of conscious, discharge time, CTor MR pathology will be retrospectively recorded. Patients were aged >18 years, had brain trauma,had amantadine sulfate therapy in ICU were included the study between June 2016-June 2017.Results: A total of 40 patients using amantadine sulfate infusion were included in the study. Itwas determined that 13 of patients had mortality. Improvement in CT and MRI findings weredetected in 21 of the living patients (77.8%). There were no differences between the mean starting time according to the clinical recovery levels and recovery status on CT-MRI. There werestatistically significant differences between starting time and time of extubation and startingtime of consciousness recovery and discharge time. Conclusion: In conclusion, we believe thatamantadine treatment accelerates neurological recovery in terms of CRS-R and clinical recovery inTBI patients.