Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA)

Introduction: The results of standard chemotherapy in lung cancer are not very satisfactory, so it is important to identify geneticmutations that provide targeted therapies. Recent reports have suggested influences of racial difference on the frequency of mutationin lung cancer. We aimed to determine the frequency and regional distribution of genetic mutations of non-small cell lung cancer(NSCLC) in Turkey.Materials and Methods: Regional distribution of genetic mutations in lung cancer in Turkey (REDIGMA) study was carried out as aprospective, cross-sectional, observational study in a large number of centers in which lung cancer patients were followed and couldperform genetic mutation analysis on patients’ biopsy materials.Results: The 703 patients (77.7% male, mean age 63.3 ± 12.5 years) who were diagnosed as NSCLC from 25 different centers wereincluded in the study. Tumor samples from patients were reported as 87.1% adenocarcinoma, 6.4% squamous cell carcinoma and6.5% other. Mutation tests were found to be positive in 18.9% of these patients. The mutations were 69.9% EGFR, 26.3% ALK, 1.6%ROS and 2.2% PDL. Mutations were higher in women and non-smokers (p< 0.000, p< 0.001). Again, the frequency of mutations inadenocarcinoma was higher in metastatic disease. There was no difference between the patient’s age, area of residence, comorbidityand clinical stage and mutation frequency.Conclusion: Our study revealed that the EGFR mutation rate in Turkey with NSCLC was similar to East European, African–Americanand Caucasian patients, and was lower than in East Asia.

Anahtar Kelime:

Türkiye’de akciğer kanserinde genetik mutasyonların bölgesel dağılımı (REDIGMA)

Öz:

Giriş: Akciğer kanserinde standart kemoterapinin sonuçları çok tatmin edici değildir, bu nedenle hedefe yönelik tedavileri sağlayan genetik mutasyonları belirlemek önemlidir. Son raporlar, ırksal farklılığın ve bölgesel değişikliğin akciğer kanserinde mutasyon sıklığı üzerindeki etkilerini göstermiştir. Çalışmamızda küçük hücreli dışı akciğer kanseri (KHDAK)'nde genetik mutasyonların Türkiye'deki sıklığını ve bölgesel dağılımını belirlemeyi amaçladık. Materyal ve Metod: Türkiye'de akciğer kanserinde genetik mutasyonların bölgesel dağılımı (REDIGMA) çalışması, akciğer kanseri hastalarının takip edildiği ve hastaların biyopsisinde genetik mutasyon analizi yapılabilecek çok sayıda merkezde prospektif, kesitsel ve gözlemsel bir çalışma olarak gerçekleştirildi. Bulgular: Çalışmaya 25 farklı merkezden KHDAK tanısı konan 703 hasta (%77.7 erkek, ortalama yaş 63.3 ± 12.5 yıl) alındı. Hastalardan alınan tümör örnekleri %87.1 adenokarsinom, %6.4 skuamöz hücreli karsinom ve %6.5 diğer olarak bildirildi. Mutasyon testleri bu hastaların %18.9'unda pozitif bulundu. Mutasyonlar %69.9 EGFR, %26.3 ALK, %1.6 ROS ve %2.2 PDL idi. Mutasyonlar kadınlarda ve sigara içmeyenlerde istatistiksel olarak daha yüksek tespit edildi (p< 0.000, p< 0.001). Yine, adenokarsinomdaki mutasyonların sıklığı metastatik hastalıkta daha yüksekti. Hastanın yaşı, ikamet alanı, komorbiditesi, klinik evresi ve mutasyon sıklığı arasında farklılık saptanmamıştır. Sonuç: Çalışmamızın sonucunda Türkiye geneli mutasyon pozitifliği literatür ile karşılaştırıldığında Türkiye’de KHDAK'lı hastalarda EGFR mutasyon oranının Doğu Avrupa, Afrikalı-Amerikalı ve Kafkasyalı hastalara benzer ve Doğu Asya'dan daha düşük olduğu ortaya koyulmuştur

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	OZCELIK N, Aksel N, BÜLBÜL Y, Erdoğan Y, GÜLDAVAL F, KARABULUT GÜL Ş, BİRCAN A, CAN A, ÖZ N, ŞENTÜRK A, ARINÇ S, KILIÇ T, Kurt E, GÜNAY E, ÇAĞLAYAN B, ÇELEBİ AYDIN D, Basyigit I, SAVAŞ İ, TATAR D, ARSLAN S, Komurcuoglu B, Bayram M, GÜLMEZ İ, DOGAN O, ÖZGÜN NİKSARLIOĞLU E, KABA E, Karaoğlanoğlu S, AYDIN ÖZGÜR E, OZCELIK A, ÖZLÜ T, GROUP R (2019). Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA). , 197 - 204. 10.5578/tt.68707
Chicago	OZCELIK Neslihan,Aksel Nimet,BÜLBÜL Yılmaz,Erdoğan Yurdanur,GÜLDAVAL FİLİZ,KARABULUT GÜL Şule,BİRCAN Ahmet,CAN Atilla,ÖZ Necdet,ŞENTÜRK Ayşegül,ARINÇ Sibel,KILIÇ Talat,Kurt EMİNE BAHAR,GÜNAY Ersin,ÇAĞLAYAN Benan Niku,ÇELEBİ AYDIN Derya,Basyigit Ilknur,SAVAŞ İSMAİL,TATAR Dursun,ARSLAN Sulhattin,Komurcuoglu Berna,Bayram Mehmet,GÜLMEZ İnci,DOGAN OMER TAMER,ÖZGÜN NİKSARLIOĞLU Elif Yelda,KABA Erkan,Karaoğlanoğlu Selen,AYDIN ÖZGÜR Esra,OZCELIK ALI ERDEM,ÖZLÜ Tevfik,GROUP REDIGMA Study Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA). (2019): 197 - 204. 10.5578/tt.68707
MLA	OZCELIK Neslihan,Aksel Nimet,BÜLBÜL Yılmaz,Erdoğan Yurdanur,GÜLDAVAL FİLİZ,KARABULUT GÜL Şule,BİRCAN Ahmet,CAN Atilla,ÖZ Necdet,ŞENTÜRK Ayşegül,ARINÇ Sibel,KILIÇ Talat,Kurt EMİNE BAHAR,GÜNAY Ersin,ÇAĞLAYAN Benan Niku,ÇELEBİ AYDIN Derya,Basyigit Ilknur,SAVAŞ İSMAİL,TATAR Dursun,ARSLAN Sulhattin,Komurcuoglu Berna,Bayram Mehmet,GÜLMEZ İnci,DOGAN OMER TAMER,ÖZGÜN NİKSARLIOĞLU Elif Yelda,KABA Erkan,Karaoğlanoğlu Selen,AYDIN ÖZGÜR Esra,OZCELIK ALI ERDEM,ÖZLÜ Tevfik,GROUP REDIGMA Study Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA). , 2019, ss.197 - 204. 10.5578/tt.68707
AMA	OZCELIK N,Aksel N,BÜLBÜL Y,Erdoğan Y,GÜLDAVAL F,KARABULUT GÜL Ş,BİRCAN A,CAN A,ÖZ N,ŞENTÜRK A,ARINÇ S,KILIÇ T,Kurt E,GÜNAY E,ÇAĞLAYAN B,ÇELEBİ AYDIN D,Basyigit I,SAVAŞ İ,TATAR D,ARSLAN S,Komurcuoglu B,Bayram M,GÜLMEZ İ,DOGAN O,ÖZGÜN NİKSARLIOĞLU E,KABA E,Karaoğlanoğlu S,AYDIN ÖZGÜR E,OZCELIK A,ÖZLÜ T,GROUP R Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA). . 2019; 197 - 204. 10.5578/tt.68707
Vancouver	OZCELIK N,Aksel N,BÜLBÜL Y,Erdoğan Y,GÜLDAVAL F,KARABULUT GÜL Ş,BİRCAN A,CAN A,ÖZ N,ŞENTÜRK A,ARINÇ S,KILIÇ T,Kurt E,GÜNAY E,ÇAĞLAYAN B,ÇELEBİ AYDIN D,Basyigit I,SAVAŞ İ,TATAR D,ARSLAN S,Komurcuoglu B,Bayram M,GÜLMEZ İ,DOGAN O,ÖZGÜN NİKSARLIOĞLU E,KABA E,Karaoğlanoğlu S,AYDIN ÖZGÜR E,OZCELIK A,ÖZLÜ T,GROUP R Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA). . 2019; 197 - 204. 10.5578/tt.68707
IEEE	OZCELIK N,Aksel N,BÜLBÜL Y,Erdoğan Y,GÜLDAVAL F,KARABULUT GÜL Ş,BİRCAN A,CAN A,ÖZ N,ŞENTÜRK A,ARINÇ S,KILIÇ T,Kurt E,GÜNAY E,ÇAĞLAYAN B,ÇELEBİ AYDIN D,Basyigit I,SAVAŞ İ,TATAR D,ARSLAN S,Komurcuoglu B,Bayram M,GÜLMEZ İ,DOGAN O,ÖZGÜN NİKSARLIOĞLU E,KABA E,Karaoğlanoğlu S,AYDIN ÖZGÜR E,OZCELIK A,ÖZLÜ T,GROUP R "Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA)." , ss.197 - 204, 2019. 10.5578/tt.68707
ISNAD	OZCELIK, Neslihan vd. "Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA)". (2019), 197-204. https://doi.org/10.5578/tt.68707

APA	OZCELIK N, Aksel N, BÜLBÜL Y, Erdoğan Y, GÜLDAVAL F, KARABULUT GÜL Ş, BİRCAN A, CAN A, ÖZ N, ŞENTÜRK A, ARINÇ S, KILIÇ T, Kurt E, GÜNAY E, ÇAĞLAYAN B, ÇELEBİ AYDIN D, Basyigit I, SAVAŞ İ, TATAR D, ARSLAN S, Komurcuoglu B, Bayram M, GÜLMEZ İ, DOGAN O, ÖZGÜN NİKSARLIOĞLU E, KABA E, Karaoğlanoğlu S, AYDIN ÖZGÜR E, OZCELIK A, ÖZLÜ T, GROUP R (2019). Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA). Tüberküloz ve Toraks, 67(3), 197 - 204. 10.5578/tt.68707
Chicago	OZCELIK Neslihan,Aksel Nimet,BÜLBÜL Yılmaz,Erdoğan Yurdanur,GÜLDAVAL FİLİZ,KARABULUT GÜL Şule,BİRCAN Ahmet,CAN Atilla,ÖZ Necdet,ŞENTÜRK Ayşegül,ARINÇ Sibel,KILIÇ Talat,Kurt EMİNE BAHAR,GÜNAY Ersin,ÇAĞLAYAN Benan Niku,ÇELEBİ AYDIN Derya,Basyigit Ilknur,SAVAŞ İSMAİL,TATAR Dursun,ARSLAN Sulhattin,Komurcuoglu Berna,Bayram Mehmet,GÜLMEZ İnci,DOGAN OMER TAMER,ÖZGÜN NİKSARLIOĞLU Elif Yelda,KABA Erkan,Karaoğlanoğlu Selen,AYDIN ÖZGÜR Esra,OZCELIK ALI ERDEM,ÖZLÜ Tevfik,GROUP REDIGMA Study Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA). Tüberküloz ve Toraks 67, no.3 (2019): 197 - 204. 10.5578/tt.68707
MLA	OZCELIK Neslihan,Aksel Nimet,BÜLBÜL Yılmaz,Erdoğan Yurdanur,GÜLDAVAL FİLİZ,KARABULUT GÜL Şule,BİRCAN Ahmet,CAN Atilla,ÖZ Necdet,ŞENTÜRK Ayşegül,ARINÇ Sibel,KILIÇ Talat,Kurt EMİNE BAHAR,GÜNAY Ersin,ÇAĞLAYAN Benan Niku,ÇELEBİ AYDIN Derya,Basyigit Ilknur,SAVAŞ İSMAİL,TATAR Dursun,ARSLAN Sulhattin,Komurcuoglu Berna,Bayram Mehmet,GÜLMEZ İnci,DOGAN OMER TAMER,ÖZGÜN NİKSARLIOĞLU Elif Yelda,KABA Erkan,Karaoğlanoğlu Selen,AYDIN ÖZGÜR Esra,OZCELIK ALI ERDEM,ÖZLÜ Tevfik,GROUP REDIGMA Study Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA). Tüberküloz ve Toraks, vol.67, no.3, 2019, ss.197 - 204. 10.5578/tt.68707
AMA	OZCELIK N,Aksel N,BÜLBÜL Y,Erdoğan Y,GÜLDAVAL F,KARABULUT GÜL Ş,BİRCAN A,CAN A,ÖZ N,ŞENTÜRK A,ARINÇ S,KILIÇ T,Kurt E,GÜNAY E,ÇAĞLAYAN B,ÇELEBİ AYDIN D,Basyigit I,SAVAŞ İ,TATAR D,ARSLAN S,Komurcuoglu B,Bayram M,GÜLMEZ İ,DOGAN O,ÖZGÜN NİKSARLIOĞLU E,KABA E,Karaoğlanoğlu S,AYDIN ÖZGÜR E,OZCELIK A,ÖZLÜ T,GROUP R Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA). Tüberküloz ve Toraks. 2019; 67(3): 197 - 204. 10.5578/tt.68707
Vancouver	OZCELIK N,Aksel N,BÜLBÜL Y,Erdoğan Y,GÜLDAVAL F,KARABULUT GÜL Ş,BİRCAN A,CAN A,ÖZ N,ŞENTÜRK A,ARINÇ S,KILIÇ T,Kurt E,GÜNAY E,ÇAĞLAYAN B,ÇELEBİ AYDIN D,Basyigit I,SAVAŞ İ,TATAR D,ARSLAN S,Komurcuoglu B,Bayram M,GÜLMEZ İ,DOGAN O,ÖZGÜN NİKSARLIOĞLU E,KABA E,Karaoğlanoğlu S,AYDIN ÖZGÜR E,OZCELIK A,ÖZLÜ T,GROUP R Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA). Tüberküloz ve Toraks. 2019; 67(3): 197 - 204. 10.5578/tt.68707
IEEE	OZCELIK N,Aksel N,BÜLBÜL Y,Erdoğan Y,GÜLDAVAL F,KARABULUT GÜL Ş,BİRCAN A,CAN A,ÖZ N,ŞENTÜRK A,ARINÇ S,KILIÇ T,Kurt E,GÜNAY E,ÇAĞLAYAN B,ÇELEBİ AYDIN D,Basyigit I,SAVAŞ İ,TATAR D,ARSLAN S,Komurcuoglu B,Bayram M,GÜLMEZ İ,DOGAN O,ÖZGÜN NİKSARLIOĞLU E,KABA E,Karaoğlanoğlu S,AYDIN ÖZGÜR E,OZCELIK A,ÖZLÜ T,GROUP R "Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA)." Tüberküloz ve Toraks, 67, ss.197 - 204, 2019. 10.5578/tt.68707
ISNAD	OZCELIK, Neslihan vd. "Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA)". Tüberküloz ve Toraks 67/3 (2019), 197-204. https://doi.org/10.5578/tt.68707