Gastric Carcinoma With Lymphoid Stroma (Gastric Medullary Carcinoma): A Rare Case Report

Ekmekci, Sumeyye; Sarioglu, Sulen; DEĞİRMENCİ, Mustafa; SAĞOL, Özgül; calik, bulent; DERE, YELDA

Gastric Carcinoma With Lymphoid Stroma (Gastric Medullary Carcinoma): A Rare Case Report

Sümeyye EKMEKÇİ, (Tepecik Eğitim ve Araştırma Hastanesi, Patoloji Kliniği, İzmir, Türkiye)

Yelda DERE, (Muğla Sıtkı Koçman Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Muğla, Türkiye)

Mustafa DEĞİRMENCİ, (Tepecik Eğitim ve Araştırma Hastanesi, Tıbbi Onkoloji Kliniği, İzmir, Türkiye)

Bülent ÇALIK, (Tepecik Eğitim ve Araştırma Hastanesi, Genel Cerrahi Kliniği, İzmir, Türkiye)

Özgül SAĞOL, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, İzmir, Türkiye)

Sülen SARIOĞLU (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, İzmir, Türkiye)

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

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Yıl: 2019 Cilt: 6 Sayı: 2 Sayfa Aralığı: 105 - 107 Metin Dili: İngilizce İndeks Tarihi: 19-08-2020

Gastric Carcinoma With Lymphoid Stroma (Gastric Medullary Carcinoma): A Rare Case Report

Öz:

Gastric carcinoma associated with lymphoid stroma (GCLS), also known as gastric medullary carcinoma is a rare neoplasia of the stomach which is characterized with poorly developed tubular structures admixed within a lymphocyte-rich stroma. Most of the GCLS are found to be associated with Epstein-Barr virus (EBV) infection. Herein we present a case of GCLS in a 76-year-old patient. Gastroscopic examination revealed an ulcerated mass located at the cardia and the biopsy was diagnosed as poorly differentiated adenocarcinoma. After gastrectomy, the microscopic examination revealed an ulcerated tumor limited to the subserosa with pushing borders and dense lymphocytic infiltrate. The tumor diffusely consisted of sheets of pleomorphic tumor cells showing vesicular nuclei. In-situ hybridization analysis of EBV encoded RNA (EBER) was positive lymphoid cells. The disease was staged as T3N0M0. He had no relapse until now and he is under follow-up for 36 months treated with adjuvant systemic treatment.

Anahtar Kelime:

Lenfoid Stroma İlişkili Gastrik Karsinom (Gastrik Meduller Karsinom): Nadir Bir Olgu Sunumu

Öz:

Mide medüller karsinomu olarak da bilinen lenfoid stroma ilişkili mide karsinomu (GCLS), lenfositlerden zengin bir stroma içerisinde kötü düzenlenmiş tübül yapıları ile karakterize midenin nadir görülen bir neoplazisidir. Çoğu GCLS Epstein- Barr virüs (EBV) ile ilişkilidir. Burada 76 yaşında erkek GCLS olgusu sunulmaktadır. Gastroskopik muayenede kardiyada ülsere kitle saptanan olgu, endoskopik biyopsisinden kötü diferansiye adenokarsinom tanısı aldı. Gastrektomi sonrası mikroskobik incelemede subserozal alanda sınırlanmış, lenfositten zengin stromada, solid paternde gelişim göstermiş büyük ve pleomorfik, veziküler nükleuslu hücrelerden oluşan, itici sınırlara sahip tümör izlendi. In-situ hibridizasyonda EBV encoded RNA (EBER) lenfoid hücrelerde pozitifti. Hastalık evre T3N0M0’dı. Hasta sistemik adjuvan tedavi almıştır. 36 aylık takibinde, şu ana kadar nüks saptanmamıştır.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık

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APA	Ekmekci S, DERE Y, DEĞİRMENCİ M, calik b, SAĞOL Ö, Sarioglu S (2019). Gastric Carcinoma With Lymphoid Stroma (Gastric Medullary Carcinoma): A Rare Case Report. , 105 - 107.
Chicago	Ekmekci Sumeyye,DERE YELDA,DEĞİRMENCİ Mustafa,calik bulent,SAĞOL Özgül,Sarioglu Sulen Gastric Carcinoma With Lymphoid Stroma (Gastric Medullary Carcinoma): A Rare Case Report. (2019): 105 - 107.
MLA	Ekmekci Sumeyye,DERE YELDA,DEĞİRMENCİ Mustafa,calik bulent,SAĞOL Özgül,Sarioglu Sulen Gastric Carcinoma With Lymphoid Stroma (Gastric Medullary Carcinoma): A Rare Case Report. , 2019, ss.105 - 107.
AMA	Ekmekci S,DERE Y,DEĞİRMENCİ M,calik b,SAĞOL Ö,Sarioglu S Gastric Carcinoma With Lymphoid Stroma (Gastric Medullary Carcinoma): A Rare Case Report. . 2019; 105 - 107.
Vancouver	Ekmekci S,DERE Y,DEĞİRMENCİ M,calik b,SAĞOL Ö,Sarioglu S Gastric Carcinoma With Lymphoid Stroma (Gastric Medullary Carcinoma): A Rare Case Report. . 2019; 105 - 107.
IEEE	Ekmekci S,DERE Y,DEĞİRMENCİ M,calik b,SAĞOL Ö,Sarioglu S "Gastric Carcinoma With Lymphoid Stroma (Gastric Medullary Carcinoma): A Rare Case Report." , ss.105 - 107, 2019.
ISNAD	Ekmekci, Sumeyye vd. "Gastric Carcinoma With Lymphoid Stroma (Gastric Medullary Carcinoma): A Rare Case Report". (2019), 105-107.

APA	Ekmekci S, DERE Y, DEĞİRMENCİ M, calik b, SAĞOL Ö, Sarioglu S (2019). Gastric Carcinoma With Lymphoid Stroma (Gastric Medullary Carcinoma): A Rare Case Report. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, 6(2), 105 - 107.
Chicago	Ekmekci Sumeyye,DERE YELDA,DEĞİRMENCİ Mustafa,calik bulent,SAĞOL Özgül,Sarioglu Sulen Gastric Carcinoma With Lymphoid Stroma (Gastric Medullary Carcinoma): A Rare Case Report. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 6, no.2 (2019): 105 - 107.
MLA	Ekmekci Sumeyye,DERE YELDA,DEĞİRMENCİ Mustafa,calik bulent,SAĞOL Özgül,Sarioglu Sulen Gastric Carcinoma With Lymphoid Stroma (Gastric Medullary Carcinoma): A Rare Case Report. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, vol.6, no.2, 2019, ss.105 - 107.
AMA	Ekmekci S,DERE Y,DEĞİRMENCİ M,calik b,SAĞOL Ö,Sarioglu S Gastric Carcinoma With Lymphoid Stroma (Gastric Medullary Carcinoma): A Rare Case Report. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi. 2019; 6(2): 105 - 107.
Vancouver	Ekmekci S,DERE Y,DEĞİRMENCİ M,calik b,SAĞOL Ö,Sarioglu S Gastric Carcinoma With Lymphoid Stroma (Gastric Medullary Carcinoma): A Rare Case Report. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi. 2019; 6(2): 105 - 107.
IEEE	Ekmekci S,DERE Y,DEĞİRMENCİ M,calik b,SAĞOL Ö,Sarioglu S "Gastric Carcinoma With Lymphoid Stroma (Gastric Medullary Carcinoma): A Rare Case Report." Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, 6, ss.105 - 107, 2019.
ISNAD	Ekmekci, Sumeyye vd. "Gastric Carcinoma With Lymphoid Stroma (Gastric Medullary Carcinoma): A Rare Case Report". Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 6/2 (2019), 105-107.