How is Aurora Kinase AExpression Altered in Chronic Lymphocytic Leukemia?

BOZKURT, GOKAY; Kadikoylu, Gurhan; bolaman, ali zahit; pektas, gokhan; Çetin, Deniz; yavasoglu, İrfan; Kacar Döger, Füruzan

How is Aurora Kinase AExpression Altered in Chronic Lymphocytic Leukemia?

Deniz ÇETİN, (Muğla Sıtkı Koçman Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, Muğla)

Gökhan PEKTAŞ, (Muğla Sıtkı Koçman Üniversitesi Tıp Fakültesi Hematoloji Anabilim Dalı, Muğla,Türkiye)

Gökay BOZKURT, (Adnan Menderes Üniversitesi Tıp Fakültesi tıbbi Genetik Anabilim Dalı, Aydın,Türkiye)

Füruzan Kacar DÖGER, (Adnan Menderes Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı, Aydın,Türkiye)

İrfan YAVAŞOĞLU, (Adnan Menderes Üniversitesi Tıp Fakültesi Hematoloji Anabilim Dalı, Aydın,Türkiye)

Zahit BOLAMAN, (Adnan Menderes Üniversitesi Tıp Fakültesi Hematoloji Anabilim Dalı, Aydın,Türkiye)

Gürhan KADIKÖYLÜ (Kent Hastanesi, Hematoloji Anabilim Dalı, İzmir)

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

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Yıl: 2020 Cilt: 7 Sayı: 1 Sayfa Aralığı: 24 - 29 Metin Dili: İngilizce İndeks Tarihi: 19-10-2020

How is Aurora Kinase AExpression Altered in Chronic Lymphocytic Leukemia?

Öz:

Aurora kinase A is an enzyme which regulates the maturation and separation of centrosomes and the assembly and stability of mitotic spindles during mitosis. The dysregulation of Aurora kinase A is related with aneuploidy and a pronounced increase in cancerrisk. This study aims to determine how the expression of Aurora kinase Aisalteredinchroniclymphocyticleukemia(CLL).This prospective case-control study reviewed 41 patients who were newlydiagnosedwithCLLand18patientswithbenign hematologicaldiseases. Bone marrow aspiration and biopsy were performed in all patients. Aurora kinase A expression in bone marrow cells was assessed by quantitative reverse transcriptase-polymerasechainreaction.Bonemarrowspecimenswere immunohistochemically stained for Aurora-A antibody. Chromosomal abnormalities including 13q deletion, 17p deletion andtrisomy12wereinvestigatedbyfluorescenceinsitu hybridization in bone marrow aspirates of CLL patients. The CLL patients and the patients with benign hematological diseases were statistically similar in aspect of Aurora kinase A mRNA expression through β-actin and GAPDH housekeeping genes (respectively p=0.742 and p=0.229). Positive immunohistochemical staining for Aurora kinase A was significantly more frequent in CLL patients (p<0.001). Immunohistochemical staining for Aurora kinase A in bone marrow biopsies of CLL patients did not change significantly with respect to cytogenetic abnormalities such as 13q deletion, 17p deletion or trisomy 12 (p>0.05 for all).Aurora kinase A may play a role in the pathogenesis of CLL but this role may not be as evident as it has previously been specified.

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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Çetin D, pektas g, BOZKURT G, Kacar Döger F, yavasoglu İ, bolaman a, Kadikoylu G (2020). How is Aurora Kinase AExpression Altered in Chronic Lymphocytic Leukemia?. , 24 - 29.
Chicago	Çetin Deniz,pektas gokhan,BOZKURT GOKAY,Kacar Döger Füruzan,yavasoglu İrfan,bolaman ali zahit,Kadikoylu Gurhan How is Aurora Kinase AExpression Altered in Chronic Lymphocytic Leukemia?. (2020): 24 - 29.
MLA	Çetin Deniz,pektas gokhan,BOZKURT GOKAY,Kacar Döger Füruzan,yavasoglu İrfan,bolaman ali zahit,Kadikoylu Gurhan How is Aurora Kinase AExpression Altered in Chronic Lymphocytic Leukemia?. , 2020, ss.24 - 29.
AMA	Çetin D,pektas g,BOZKURT G,Kacar Döger F,yavasoglu İ,bolaman a,Kadikoylu G How is Aurora Kinase AExpression Altered in Chronic Lymphocytic Leukemia?. . 2020; 24 - 29.
Vancouver	Çetin D,pektas g,BOZKURT G,Kacar Döger F,yavasoglu İ,bolaman a,Kadikoylu G How is Aurora Kinase AExpression Altered in Chronic Lymphocytic Leukemia?. . 2020; 24 - 29.
IEEE	Çetin D,pektas g,BOZKURT G,Kacar Döger F,yavasoglu İ,bolaman a,Kadikoylu G "How is Aurora Kinase AExpression Altered in Chronic Lymphocytic Leukemia?." , ss.24 - 29, 2020.
ISNAD	Çetin, Deniz vd. "How is Aurora Kinase AExpression Altered in Chronic Lymphocytic Leukemia?". (2020), 24-29.

APA	Çetin D, pektas g, BOZKURT G, Kacar Döger F, yavasoglu İ, bolaman a, Kadikoylu G (2020). How is Aurora Kinase AExpression Altered in Chronic Lymphocytic Leukemia?. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, 7(1), 24 - 29.
Chicago	Çetin Deniz,pektas gokhan,BOZKURT GOKAY,Kacar Döger Füruzan,yavasoglu İrfan,bolaman ali zahit,Kadikoylu Gurhan How is Aurora Kinase AExpression Altered in Chronic Lymphocytic Leukemia?. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 7, no.1 (2020): 24 - 29.
MLA	Çetin Deniz,pektas gokhan,BOZKURT GOKAY,Kacar Döger Füruzan,yavasoglu İrfan,bolaman ali zahit,Kadikoylu Gurhan How is Aurora Kinase AExpression Altered in Chronic Lymphocytic Leukemia?. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, vol.7, no.1, 2020, ss.24 - 29.
AMA	Çetin D,pektas g,BOZKURT G,Kacar Döger F,yavasoglu İ,bolaman a,Kadikoylu G How is Aurora Kinase AExpression Altered in Chronic Lymphocytic Leukemia?. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi. 2020; 7(1): 24 - 29.
Vancouver	Çetin D,pektas g,BOZKURT G,Kacar Döger F,yavasoglu İ,bolaman a,Kadikoylu G How is Aurora Kinase AExpression Altered in Chronic Lymphocytic Leukemia?. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi. 2020; 7(1): 24 - 29.
IEEE	Çetin D,pektas g,BOZKURT G,Kacar Döger F,yavasoglu İ,bolaman a,Kadikoylu G "How is Aurora Kinase AExpression Altered in Chronic Lymphocytic Leukemia?." Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, 7, ss.24 - 29, 2020.
ISNAD	Çetin, Deniz vd. "How is Aurora Kinase AExpression Altered in Chronic Lymphocytic Leukemia?". Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 7/1 (2020), 24-29.