Objective: In recent years neutrophil-to-lymphocyte ratio is defined as one of the new and early prognostic markersfor many carcinomas including some types of intracranial tumors. The aim of the present study is to assess theassociation between preoperative and postoperative neutrophil-to-lymphocyte ratios and remissions in patientswith Cushing’s disease.Method: The present study was carried out using the data of 162 consecutive patients operated for Cushing’sdisease by a single surgeon (NG) between 1997 and 2017. Clinical records were analyzed retrospectively.Neutrophil-to-lymphocyte ratios calculated from complete blood counts recorded preoperatively, on postoperative1st day and at postoperative 3rd month in 24 patients in early, and 3rd month remissions and correlations amongthem were investigated.Results: A statistically significant difference was observed between preoperative, postoperative 1st day and postoperative 3rd month NLRs in patients who were in early stage emission (p=0.001) or not (p=0.002). Any statisticallysignificant difference was not found between patients who were in remission or not at 3rd months in terms of NLRsmeasured at different time points. There was a statistically significant difference between preoperative, postoperative first day and postoperative 3rd month NLRs in patients in remission (p=0.001) or not (p=0.005) during longterm follow-up. No statistically significant difference was found between NLRs measured at different times amongthose who were remission or not during long-term follow-up.Conclusion: Cushing’s disease is a disease directly associated with stress hormones and its effects on NLR is inevitable. New studies with larger patient series will shed light on this issue.