Efficiency of piroxicam in fibromyalgia syndrome. The possible efficiency of a nonsteroid anti-inflammatory drug piroxicam in fibromyalgia syndrome on pain and pain originated disabilities in daily life is investigated in this study. A group of 49 patients (6 male and 43 female) with fibromyalgia syndrome diagnosed according to American College of Rheumatology 1990 criteria were recruited for the study. A comprehensive history including demographic information, pain history and disabilities of the patients were recorded. The home therapy program consisting thirty-minutes daily jogging, home exercises such as strecthing body muscles and paracetamol tablet when needed was performed during the thirty day observation period for all patients. In addition, daily sublingual piroxicam tablet was perscribed to the first 29 patients consecutively. After the therapy, patients were reevaluated and new findings were compared with the first findings. Significant relief in pain and fatigue complaints and on disability scores were achieved, and less paracetamol tablets were used in piroxicam taking group. However, any improvement in patients' self rating health measurement was not detected. On the other hand in control group who were not prescribed piroxicam, the only parameter which was obtained a significant improvement on was Visual Analog Scale (VAS). In conclusion, it is suggested that piroxicam can be used for the pain in fibromyalgia syndrome, but the education of patient, modification the patient's lifestyle, and home compatible exercise program have to also be considered as a part in general therapy approach.