The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension

KAYMAKOĞLU, Selahattin; Demir, Kadir; İBRİŞİM, Duygu; Badur, selim; YEKELER, Ensar; ÖKTEN, Atilla; AKSOY, Nevzat; HORASANLI, Sibel; POTUROĞLU, ŞULE; Akyuz, Filiz

The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension

Filiz AKYÜZ, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Gastroenterohepatoloji Anabilim Dalı, İstanbul, Türkiye)

Ensar YEKELER, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Radyoloji Anabilim Dalı, İstanbul, Türkiye)

Selahattin KAYMAKOĞLU, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Gastroenterohepatoloji Bilim Dalı, İstanbul, Türkiye)

Sibel HORASANLI, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

Duygu İBRİŞİM, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Gastroenterohepatoloji Anabilim Dalı, İstanbul, Türkiye)

Kadir DEMİR, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Gastroenterohepatoloji Anabilim Dalı, İstanbul, Türkiye)

Nevzat AKSOY, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Gastroenterohepatoloji Anabilim Dalı, İstanbul, Türkiye)

Şule POTUROĞLU, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Gastroenterohepatoloji Anabilim Dalı, İstanbul, Türkiye)

Selim BADUR, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)

Atilla ÖKTEN (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Gastroenterohepatoloji Anabilim Dalı, İstanbul, Türkiye)

Turkish Journal of Gastroenterology

2 0

Yıl: 2007 Cilt: 18 Sayı: 2 Sayfa Aralığı: 95 - 99 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension

Öz:

Amaç: Sirotik ve nonsirotik portal hipertansiyon tanısı konulan hastalarda trombopoetin ve dalak hacminin trombositopenideki etkisini araştırmaktır. Yöntem: Çalışmaya portal hipertansiyonu olan 74 hasta (grup 1: 28 nonsirotik; grup 2: 46 sirotik) alındı. Dalak hacmi magnetik rezonans görüntüleme ile hesaplandı. Trombopoetin ve hyaluronik asid serumda ELISA ile tayin edildi. Bulgular: Dalak hacmi grup 1’de (1375±658.74 mL) grup 2’ye (981.78±512.39 mL) göre anlamlı olarak büyüktü. Grup 1’de trombopoetin düzeyi 76.6±30.39 pg/ml, hyaluronik asid düzeyi 78.17±66.67 ng/ml olarak bulundu. Trombopoetin (99.89±38.5 pg/ml) ve hyaluronik asid (271.97±197.34 ng/ml) düzeyleri grup 2’de grup 1’den daha yüksekti (p<0.05). Her iki grupta da trombosit ve trombopoetin düzeyleri ile dalak hacmi arasında negatif korelasyon saptandı (p <0.05). Sirotik ve nonsirotik gruplarda serum trombopoetin düzeyleri ile trombosit düzeyleri arasında korelasyon yoktu. Fakat tüm grupta trombopoetin düzeyi ile dalak hacmi arasında negatif korelasyon saptandı (p=0.044, r= - 0.23). Dalak hacmi nonsirotik hastalarda anlamlı olarak daha büyük olmasına rağmen, trombosit düzeyleri her iki grupta da benzerdi. Sonuç: Bu çalışma portal hipertansif hastalarda trombositopeninin esas nedeninin dalaktaki sekestrasyon olduğunu göstermiştir. Bu sonuçlar trombosit düzeyleri üzerinde trombopoetin sentezindeki azalmadan daha çok trombopoetin üretimi ve yıkımı arasındaki dengenin önemli olabileceğini düşündürmüştür.

Anahtar Kelime: Trombopoietin Enzim bağlı immünosorbent tayini Hipertansiyon, portal İleriye dönük çalışma Trombositopeni Trombosit sayısı Splenomegali Hiyalüronik asit Dalak Karaciğer sirozu

Konular: Cerrahi

Sirotik ve nonsirotik portal hipertansiyonlu hastalarda trombopoetin ve dalak hacminin rolü

Öz:

Background/aims: To determine the role of thrombopoietin and spleen volume in thrombocytopenia diagnosed in cirrhotic and noncirrhotic portal hypertensive patients. Methods: Seventy- four portal hypertensive patients (group 1: 28 noncirrhotic; group 2: 46 cirrhotic) were enrolled into this study. Spleen volume was measured by magnetic resonance imaging. Thrombopoietin and hyaluronic acid were detected by ELISA in sera. Results: Splenic volume was significantly higher in group 1 (1375±658.74 ml) than group 2 (981.78±512.39 ml). In group 1, thrombopoietin and hyaluronic acid levels were 76.6±30.39 pg/ml and 78.17±66.67 ng/ml, respectively. These values were significantly higher in group 2, at 99.89±38.5 pg/ml and 271.97±197.34 ng/ml, respectively (p<0.05). Platelet counts and thrombopoietin levels had a negative correlation with spleen volume in both groups (p<0.05). Serum thrombopoietin levels were not correlated with platelet counts in cirrhotic and noncirrhotic groups; however, thrombopoietin levels were negatively correlated with splenic volume in the whole group (p= 0.044, r= - 0.23). Although spleen volume was significantly larger in noncirrhotic patients, platelet counts were similar in both groups. Conclusions: This study confirms that splenic sequestration is the main factor in the thrombocytopenia in portal hypertensive patients. The balance of thrombopoietin production and degradation may be more important for platelet counts than decreasing synthesis.

Anahtar Kelime: Splenomegaly Hyaluronic Acid Spleen Liver Cirrhosis Thrombopoietin Enzyme-Linked Immunosorbent Assay Hypertension, Portal Prospective Studies Thrombocytopenia Platelet Count

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Akyuz F, YEKELER E, KAYMAKOĞLU S, HORASANLI S, İBRİŞİM D, Demir K, AKSOY N, POTUROĞLU Ş, Badur s, ÖKTEN A (2007). The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension. , 95 - 99.
Chicago	Akyuz Filiz,YEKELER Ensar,KAYMAKOĞLU Selahattin,HORASANLI Sibel,İBRİŞİM Duygu,Demir Kadir,AKSOY Nevzat,POTUROĞLU ŞULE,Badur selim,ÖKTEN Atilla The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension. (2007): 95 - 99.
MLA	Akyuz Filiz,YEKELER Ensar,KAYMAKOĞLU Selahattin,HORASANLI Sibel,İBRİŞİM Duygu,Demir Kadir,AKSOY Nevzat,POTUROĞLU ŞULE,Badur selim,ÖKTEN Atilla The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension. , 2007, ss.95 - 99.
AMA	Akyuz F,YEKELER E,KAYMAKOĞLU S,HORASANLI S,İBRİŞİM D,Demir K,AKSOY N,POTUROĞLU Ş,Badur s,ÖKTEN A The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension. . 2007; 95 - 99.
Vancouver	Akyuz F,YEKELER E,KAYMAKOĞLU S,HORASANLI S,İBRİŞİM D,Demir K,AKSOY N,POTUROĞLU Ş,Badur s,ÖKTEN A The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension. . 2007; 95 - 99.
IEEE	Akyuz F,YEKELER E,KAYMAKOĞLU S,HORASANLI S,İBRİŞİM D,Demir K,AKSOY N,POTUROĞLU Ş,Badur s,ÖKTEN A "The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension." , ss.95 - 99, 2007.
ISNAD	Akyuz, Filiz vd. "The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension". (2007), 95-99.

APA	Akyuz F, YEKELER E, KAYMAKOĞLU S, HORASANLI S, İBRİŞİM D, Demir K, AKSOY N, POTUROĞLU Ş, Badur s, ÖKTEN A (2007). The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension. Turkish Journal of Gastroenterology, 18(2), 95 - 99.
Chicago	Akyuz Filiz,YEKELER Ensar,KAYMAKOĞLU Selahattin,HORASANLI Sibel,İBRİŞİM Duygu,Demir Kadir,AKSOY Nevzat,POTUROĞLU ŞULE,Badur selim,ÖKTEN Atilla The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension. Turkish Journal of Gastroenterology 18, no.2 (2007): 95 - 99.
MLA	Akyuz Filiz,YEKELER Ensar,KAYMAKOĞLU Selahattin,HORASANLI Sibel,İBRİŞİM Duygu,Demir Kadir,AKSOY Nevzat,POTUROĞLU ŞULE,Badur selim,ÖKTEN Atilla The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension. Turkish Journal of Gastroenterology, vol.18, no.2, 2007, ss.95 - 99.
AMA	Akyuz F,YEKELER E,KAYMAKOĞLU S,HORASANLI S,İBRİŞİM D,Demir K,AKSOY N,POTUROĞLU Ş,Badur s,ÖKTEN A The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension. Turkish Journal of Gastroenterology. 2007; 18(2): 95 - 99.
Vancouver	Akyuz F,YEKELER E,KAYMAKOĞLU S,HORASANLI S,İBRİŞİM D,Demir K,AKSOY N,POTUROĞLU Ş,Badur s,ÖKTEN A The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension. Turkish Journal of Gastroenterology. 2007; 18(2): 95 - 99.
IEEE	Akyuz F,YEKELER E,KAYMAKOĞLU S,HORASANLI S,İBRİŞİM D,Demir K,AKSOY N,POTUROĞLU Ş,Badur s,ÖKTEN A "The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension." Turkish Journal of Gastroenterology, 18, ss.95 - 99, 2007.
ISNAD	Akyuz, Filiz vd. "The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension". Turkish Journal of Gastroenterology 18/2 (2007), 95-99.