Osteoartritte intraartiküler hyalüronik asit tedavisi

DIRAÇOĞLU, Demirhan

Osteoartritte intraartiküler hyalüronik asit tedavisi

Demirhan DIRAÇOĞLU (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, İstanbul, Türkiye)

Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi

68 4

Yıl: 2007 Cilt: 53 Sayı: 4 Sayfa Aralığı: 154 - 159 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Osteoartritte intraartiküler hyalüronik asit tedavisi

Öz:

Osteoartrit (OA) dünya üzerinde en sık rastlanan kronik eklem hastalığıdır. OA tedavisinde intraartiküler hyalüronik asit (HA) uygulamaları giderek yaygınlaşmaktadır. Ancak bu tedavi yöntemi hakkında pek çok hekimin kafasında hala bir takım sorular mevcuttur. Bu yazıda yapılan klinik araştırmaların ışığında OA tedavisinde intraartiküler HA uygulamalarının yeri gözden geçirilmiştir. Bu konuda yapılmış çok sayıda araştırma mevcuttur. Diz OA’sında HA’ların ağrı ve fonksiyonel düzelme açısından kanıta dayalı tıp metodolojisine göre kanıt düzeyi 1b’dir. Amerika Birleşik Devletleri’nde ve Avrupa’da yayınlanan pek çok tedavi klavuzunda diz OA tedavisinde önerilmektedir. İlk ve en sık kullanıldığı eklem diz eklemidir. Diğer eklemlere yapılacak uygulamalar da ümit vaad etmektedir ancak bu konuda çalışmalara ihtiyaç vardır. Her ne kadar karşıt görüşler olsa da yapılan çok sayıda in-vitro çalışma olumludur ve in-vivo kontrollü klinik çalışmalar ile diz OA’sında intraartiküler HA uygulamalarının plaseboya üstünlüğü gösterilmiştir. Tedavinin etkin olup olmadığını söyleyebilmek için doğru seçilmiş hastalar üzerinde uygulama yapılmalı ve bulgular değerlendirilmelidir. İstenmeyen etkiler arasında en sık görüleni psödoseptik reaksiyondur. Bu lokal etki geçicidir ve çoğunlukla enjeksiyon tekniği ile ilişkilidir.

Anahtar Kelime: Osteoartrit Hiyalüronik asit Enjeksiyon, eklem içi İlaç toksisitesi

Konular: Genel ve Dahili Tıp

Intra-articular hyaluronic acid in the management of osteoarthritis

Öz:

Osteoarthritis (OA) is the most common chronic joint disease in the world. Intra-articular hyaluronic acid (HA) managements have been pervading increasingly in the OA treatment. But many physicians have still plenty of questions about this method. In this article, intra-articular HA management in OA treatment was reviewed in the light of clinic investigations. Actually there are many researches about this subject. Pain and functional recovery rank is 1b evidence level with HA management in knee OA according to evidence-based medicine methodology. HA is recommended in the knee OA treatment in a lot of guidelines published in USA and Europe. First and the most common application area is knee joint. Carrying out for other joints are hopeful but we need more quality studies about this topic. Although there are opposite point of views, many in-vitro studies are constructive and, effectiveness of HA managements beyond the placebo was shown with in-vivo controlled clinic studies. To state whether the treatment is effective or not, application must be done on patients chosen properly and findings must be evaluated objectively. Pseudoseptic reaction is the most seen side effect. This local effect is temporary and in general it is relation with the injection technique.

Anahtar Kelime: Hyaluronic Acid Injections, Intra-Articular Drug Toxicity Osteoarthritis

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	DIRAÇOĞLU D (2007). Osteoartritte intraartiküler hyalüronik asit tedavisi. , 154 - 159.
Chicago	DIRAÇOĞLU Demirhan Osteoartritte intraartiküler hyalüronik asit tedavisi. (2007): 154 - 159.
MLA	DIRAÇOĞLU Demirhan Osteoartritte intraartiküler hyalüronik asit tedavisi. , 2007, ss.154 - 159.
AMA	DIRAÇOĞLU D Osteoartritte intraartiküler hyalüronik asit tedavisi. . 2007; 154 - 159.
Vancouver	DIRAÇOĞLU D Osteoartritte intraartiküler hyalüronik asit tedavisi. . 2007; 154 - 159.
IEEE	DIRAÇOĞLU D "Osteoartritte intraartiküler hyalüronik asit tedavisi." , ss.154 - 159, 2007.
ISNAD	DIRAÇOĞLU, Demirhan. "Osteoartritte intraartiküler hyalüronik asit tedavisi". (2007), 154-159.

APA	DIRAÇOĞLU D (2007). Osteoartritte intraartiküler hyalüronik asit tedavisi. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 53(4), 154 - 159.
Chicago	DIRAÇOĞLU Demirhan Osteoartritte intraartiküler hyalüronik asit tedavisi. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi 53, no.4 (2007): 154 - 159.
MLA	DIRAÇOĞLU Demirhan Osteoartritte intraartiküler hyalüronik asit tedavisi. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, vol.53, no.4, 2007, ss.154 - 159.
AMA	DIRAÇOĞLU D Osteoartritte intraartiküler hyalüronik asit tedavisi. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi. 2007; 53(4): 154 - 159.
Vancouver	DIRAÇOĞLU D Osteoartritte intraartiküler hyalüronik asit tedavisi. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi. 2007; 53(4): 154 - 159.
IEEE	DIRAÇOĞLU D "Osteoartritte intraartiküler hyalüronik asit tedavisi." Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 53, ss.154 - 159, 2007.
ISNAD	DIRAÇOĞLU, Demirhan. "Osteoartritte intraartiküler hyalüronik asit tedavisi". Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi 53/4 (2007), 154-159.