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1. The association of neuropathic pain and disease activity, functional level, and quality of life in patients with ankylosing spondylitis: a cross-sectional study
Yıl: 2018 Cilt: 48 Sayı: 2 Sayfa Aralığı: 257 - 265
Veri Tabanı: Fen

Background/aim: Increased neuropathic pain (NP) symptoms are seen in rheumatologic diseases such as fibromyalgia, osteoarthritis, and rheumatoid arthritis, but no studies have demonstrated a relationship between ankylosing spondylitis (AS) and NP except for a brain imaging study. The aim of this study was to estimate the presence of NP in patients with AS and to investigate how NP was related to disease activity, functional status, and quality of life. Materials and methods: A total of 100 AS patients (71 males and 29 females; median age: 37 years, range: 18–71 years) were included in the study. Pain (visual analog scale (VAS) and the painDETECT questionnaire), disease activity (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Maastricht Ankylosing Spondylitis Enthesitis Score (MASES), Patient Global Assessment of Disease Activity (PGA), and Ankylosing Spondylitis Disease Activity Score (ASDAS)), functional level (Bath Ankylosing Spondylitis Functional Index (BASFI)), and health-related quality of life (36-Item Short Form Survey (SF-36)) were evaluated. Patients were divided into two groups. Group 1 included patients with possible or likely NP symptoms (painDETECT score of ≥13) and Group 2 included patients without NP symptoms (painDETECT score of <13). Results: Low back pain-VAS, peripheral joint-VAS, BASDAI, PGA, ASDAS, and BASFI scores were significantly higher in Group 1 compared to those of Group 2 (P < 0.05). The SF-36 physical component (PC) score was significantly lower in Group 1 compared to that of Group 2 (P < 0.05). There were no significant differences between the groups regarding SF-36 mental component (MC) scores, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) values and MASES scores. Total painDETECT scores correlated positively with low back pain-VAS, peripheral joint-VAS, morning stiffness-VAS, BASDAI, ASDAS-CRP, ASDAS-ESR, PGA, BASFI, and MASES scores and ESR values, and inversely with SF-36 PC scores. Conclusion: Our results suggest that AS patients should be evaluated in terms of NP in order not to underestimate NP. If clinicians find evidence of likely NP, they should treat the patient with drugs that target NP.

2. Effect of Illness Perception on the Quality of Life in Ankylosing Spondylitis
Yıl: 2018 Cilt: 18 Sayı: 1 Sayfa Aralığı: 94 - 102
Veri Tabanı: Fen

Objectives: The aim of the study was to assess the illness perception in patients with ankylosing spondilitis (AS), to evaluate disease activity, functional ability, emotional status and to investigate their association with quality of life (QoL). Materials and Methods: Sixty‐seven patients with AS were included in this study. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) were used for the assessment of disease activity and of physical functions, respectively. The Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire was used for disease‐related quality of life and The Brief Illness Perception Questionnaire (B‐IPQ) was used for the assessment of illness perception in AS patients. Beck Depression Inventory (BDI) was used for the assessment of psychological status. Results: Based on our results, significant association was found between QoL and illness perceptions. However, QoL was most associated with functional status and disease activity. Conclusion: Assessment of illness perception in routine clinical practice could contribute to a better understanding of problems in patients’ behavior that may disturb adherence to treatment. Psychotherapeutic approaches in addition to conventional therapy might attempt to improve patient’s QoL in AS.

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