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1. The role of heparin-binding protein in the diagnosis of acute mesenteric ischemia
Yıl: 2019 Cilt: 25 Sayı: 3 Sayfa Aralığı: 205 - 212
Veri Tabanı: Fen

BACKGROUND: Acute mesenteric ischemia (AMI) is associated with a high mortality rate, yet diagnostic difficulties persist.Although many biomarkers have been investigated for diagnostic purposes, as well as imaging methods, a sufficiently specific and sensitive marker has not been identified. This research was designed to examine whether heparin-binding protein (HBP), which has a rolein the early phase of inflammation, could be useful in the diagnosis of AMI.METHODS: Serum samples obtained from a previously performed rabbit model of AMI were used in the study. HBP, C-reactiveprotein (CRP) and interleukin 6 (IL-6) levels were measured in blood samples obtained at baseline and 1, 3, and 6 hours from subjectsthat were separated into 3 groups: control, sham, and ischemia. The change in each marker over time and comparisons of the groupswere evaluated statistically.RESULTS: A significant difference was not detected at the first hour in any of the studied markers. At the third hour, the CRP andIL-6 levels in the ischemia group indicated a significant increase in comparison with the control and sham groups (p<0.001). The HBPvalues showed a significant increase at the sixth hour in the ischemia group in comparison with the others (p<0.001).CONCLUSION: The HBP level demonstrated a slower increase in a rabbit model of AMI compared with CRP and IL-6. However,it still has the potential to become an early diagnostic biomarker. Diagnostic sensitivity and specificity should be evaluated in further clinical trials.

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