Ahmet UYANIKOĞLU, Tevfik SABUNCU,
Rukiye YILDIZ , Çiğdem CİNDOĞLU, Adnan KİRMİT, Özcan EREL
Ahmet UYANIKOĞLU, Tevfik SABUNCU,
Rukiye YILDIZ ,
Çiğdem CİNDOĞLU, Adnan KİRMİT, Özcan EREL
Background/Aims: The aim of this study was to compare the dynamic thiol/disulfide (SS) homeostasis and ischemia-modified albumin
(IMA) concentration between healthy subjects and patients with mild acute pancreatitis (AP).
Materials and Methods: A total of 28 patients with AP (AP group) and 35 age- and sex-matched healthy individuals (control group) were
included in this study. Serum thiols/SS and IMA concentrations were measured and compared between the two groups.
Results: The mean serum native thiol (SH) and total thiol (TT) levels were significantly lower in the AP group than in the control group
(224.7±80.3 μmol/L vs. 314.66±87.5 μmol/L, p<0.001 and 273.3±76.8 vs. 346.9±79 μmol/L, p<0.001, respectively). SS levels were significantly higher in the AP group than in the control group (24.2±11.1 μmol/L vs. 16.1±9.9 μmol/L, p<0.054). There were no differences in the
IMA concentration and the mean IMA/albumin ratio (IMAR) between both the groups.
Conclusion: We found that mild AP may affect serum thiol and SS levels, and cause impaired thiol/SS homeostasis.
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Erhan ŞENSOY, Yasemin ÖZNURLU
Erhan ŞENSOY, Yasemin ÖZNURLU
Background/Aims: The aim of the present study was to determine the changes on the small intestine in mice during pregnancy using
histological, enzyme histochemical, and immunohistochemical methods.
Materials and Methods: A total of 24 Swiss albino female mice were divided as non-pregnant/control, first week, second week, and third
week of pregnancy (n=6). Tissue samples obtained from the duodenum, jejunum, and ileum were processed by means of routine histological techniques and stained with Crossmon’s triple staining. Alkaline phosphatase (ALP) was demonstrated with the simultaneous
azo-coupling method. Proliferating cell nuclear antigen (PCNA) was demonstrated with the streptavidin-biotin-peroxidase complex
method. The numerical data of the parameters were obtained and analyzed statistically.
Results: Villus height, villus width, and the rate of villus height/crypt depth were decreased in the duodenum, jejunum, and ileum in the
last week of pregnancy compared with the control group. Changes in the crypt depth of the duodenum, jejunum, and ileum in pregnancy
were found. The muscle width increased in pregnancy. It was identified that the ALP reactivity statistically significantly increased in the
duodenum, jejunum, and ileum in pregnancy. The percentage of PCNA-positive cells in the duodenum, jejunum, and ileum increased in
the first and second weeks of pregnancy, whereas it decreased in the third week of pregnancy compared with non-pregnant control
animals.
Conclusion: In conclusion, villus parameters, ALP reactivity, and percentage of PCNA-positive cells in the small intestine were affected
during pregnancy.
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Seyit UYAR, Adil DUMAN,
Ayşe TAN , Ferda AKBAY HARMANDAR, Gülşah İNAL, Gökhan KÖKER, Yasin ŞAHİNTÜRK, Feyzi BOSTAN, Ayhan Hilmi ÇEKİN
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Hakan KAYA, Sezgin BARUTÇU
Hakan KAYA, Sezgin BARUTÇU
Background/Aims: Gastroesophageal Reflux Disease (GERD) is a clinical entity affecting the upper gastrointestinal tract. The pathophysiology of GERD has been associated with autonomic nervous system disorders. Autonomic nervous system disturbances in GERD
patients have been shown to lead to fatal ventricular arrhythmias (VAs) that result in electrical and ventricular repolarization anomalies.
The maximum to terminal electrocardiographic T wave (Tpe) has been associated with repolarization of transmural dispersion. In addition, a higher Tpe interval (TpeI) and Tpe/QT ratio correspond with VAs. The goal of this report was to assess ventricular repolarization,
by TpeI and Tpe/QT ratio, in GERD patients.
Materials and Methods: The study was comprised of 46 GERD subjects and 43 healthy volunteers. TpeI, cTpe, and Tpe/Q ratios were
determined from electrocardiograms and associations of the groups were compared.
Results: The clinical characteristics were similar between the two groups. TpeI, corrected Tpe (cTpe) interval, and Tpe/QT ratio were
higher in subjects with GERD in comparison to the control group (P<0.001, P=0.018, and P<0.001, respectively).
Conclusion: TpeI and Tpe/QT ratio were higher in GERD patients. Patients with GERD may have an increased risk for VAs
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Background/Aims: This study was conducted to evaluate the outcomes of endoscopic-ultrasound-guided gallbladder drainage (EUSGBD) using traditional biliary stents without lumen-apposing stents and to determine technical issues.
Materials and Methods: All 18 patients who underwent EUS-GBD at our center between 2012 and 2018 were evaluated. After the clinical outcomes (including technical success, clinical effectiveness, adverse events, and recurrence) were analyzed, technical countermeasures for problems extracted from the analysis were developed.
Results: The rates of technical success, clinical effectiveness, severe adverse event occurrence, and recurrence of acute cholecystitis
were 94% (17/18), 88% (15/17), 6% (1/18, massive bile leakage), and 27% (4/15), respectively. Distal gastrectomy causing scope instability, the non-swollen gallbladder, and double pigtail stent use caused technical difficulties. A fully covered metal stent (fcMS) should
be placed in a shallow position so that it does not wedge into the opposite site. When the puncture route involves the gastric wall, the
proximal portion of an fcMS located in the stomach can migrate toward the abdominal cavity.
Conclusion: Although the clinical outcomes of EUS-GBD were relatively favorable, several technical issues related specifically to EUSGBD were observed. Technical countermeasures would improve the outcomes.
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Işıl BAŞARA AKIN, Canan ALTAY, Göksel BENGİ, Oktay TARHAN, Mustafa SEÇİL
Işıl BAŞARA AKIN, Canan ALTAY, Göksel BENGİ, Oktay TARHAN, Mustafa SEÇİL
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