Müjgan TEK, Mehmet Serkan ÇETİN, Berkten BERKALP, Basri AMASYALI, Mehmet ÖZGEYİK, Savaş Akyürek ÇELEBİ, Erdem DİKER
Müjgan TEK, Mehmet Serkan ÇETİN, Berkten BERKALP, Basri AMASYALI, Mehmet ÖZGEYİK, Savaş Akyürek ÇELEBİ,
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Objective: Reduced baseline hemoglobin level is associated with worse outcomes in many cardiovascular conditions including percutaneous interventions of native coronary arteries. However, this relationship has not been studied in saphenous vein graft disease undergoing elective percutaneous intervention. Metods: In this study, we evaluated baseline hemoglobin levels of 105 patients undergoing saphenous vein graft intervention. The mean follow-up was 42.4±18.4 months, and the end-point of our study was all-cause mortality. Results: Twelve patients suffered all-cause mortality, and these patients’ mean baseline hemoglobin levels were 2 g/dl lower (11.7±1.0 vs. 13.7±1.5, p=0.005), and their ejection fractions were 22% lower (49.3±10,8 vs. 38.3±12,4, p=0.014) than those of the patients without all-cause mortality. A hemoglobin cut-off 12.55 g/dL discriminated all-cause mortality with an accuracy of 85% (sensitivity: 83,3%, specificity: 76.4%, p=<0.001). Survival curve demonstrated a survival benefit of twenty-one months for the patients with hemoglobin levels higher than 12.55 g/dl (cumulative survival 95.3% vs. 70%, Log-rank p-value 0.001). Conclusion: In summary, baseline hemoglobin levels may be associated with all-cause mortality in patients undergoing elective saphenous vein graft interventions.
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Objective: We aimed to compare the normal main portal vein diameter measured in computed tomography with the commonly used upper limit value. Materials and Method: Computed tomography examinations performed between March 2015 and April 2018 in our department were scanned from the archive system. Mean portal vein diameters were measured on axial contrast-enhanced and non-enhanced abdominal CT scans of the patients without any known disease. Results: 500 main portal vein measurements were performed from 276 individuals. In the non-enhanced images (n = 243), the mean diameter of main portal vein was 15.03 ± 1.72 mm and in the post-contrast enhanced images (n = 257) the mean diameter of the main portal vein was 15,05 ± 1.71 mm. These values showed a significant difference from the widely accepted upper limit of 13 mm (95% confidence interval for non-enhanced images: 1.81-2.25 mm higher, p <0.001, 95% confidence interval for post-contrast images: 1.84-2.26 mm higher, p <0.001). The mean main portal vein diameter measured from contrast tomography images was 0.26 mm wider than the mean main portal vein diameter measured at non-enhanced images (95% confidence interval: 0.23-0.29 mm, p <0.001). Conclusion: The mean normal portal vein diameter measured in computed tomography (15.05 mm) was significantly higher than the accepted upper limit of 13 mm (p <0.0001). The mean main portal vein diameter in contrast-enhanced tomography was 0.26 mm larger than the mean main portal vein diameter measured in the non-enhanced examination.
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Burcu CERCİ GÜRBÜZ, Mustafa SOYOZ, Tülay KILIÇARSLAN AYNA, İbrahim PİRİM
Burcu CERCİ GÜRBÜZ, Mustafa SOYOZ, Tülay KILIÇARSLAN AYNA, İbrahim PİRİM
Human leucocyte antigen-G (HLA-G) is a non-classical HLA that researchers primarily focused on association with the complications of pregnancy. Recent studies about the immunomodulatory characteristics of HLA-G showed that this molecule is not only important in pregnancy but also have effects on transplantation, autoimmune diseases, cancer and infectious diseases. The restricted polymorphic nature and the disease association has also showed in various studies. In this review it was aimed to evaluate the benefits and damages of the HLA-G by considering both the expression levels and polymorphisms.
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Purpose: To evaluate the histopathologic changes in the cornea due to topical mitomycin C (MMC) application at various doses and administration periods. Materials and Methods: The study group consisted of 35 albino rabbits with a mean age of 6 months. The animals were divided into the 7 groups, each comprising 10 eyes of five rabbits. Five rabbits were used as the control group. Other subjects were divided into the 2 groups according to the application period. The first 3 groups subsequently underwent 0.2, 0.4, and 0.8 mg/mL mitomycin C application 6 times at weekly intervals. Groups 4, 5 and 6 underwent MMC application at the same doses 12 times. The control group underwent topical physiologic serum application. After the last treatment, the rabbits were sacrificed and enucleation was performed . Results: Light and electron microscopic examinations of mitomycin C treated animals revealed different histopathologic changes in the corneal epithelium and endothelium according to various doses and administration periods. Discussion: Topical mitomycin C has toxic effects on the cornea related to dose and period and is known to be more toxic, especially in increased doses.. In this study, we identified the most effective dose without side effects. Long-term treatment with MMC at low doses is more advantageous than short-term treatment at high doses.
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Objective: In this study, the primary objective was to compare CD 74 antigen levels between patients with ankylosing spondylitis (AS) and healthy controls. The secondary objective was to investigate the distribution of Macrophage Migration Inhibitory Factor (MIF) 173 G/C polymorphisms in AS patients and a control group. Finally, it was also aimed to reveal the presence of a relationship between CD 74 antigen levels and MIF 173 G/C polymorphism. Materials and Methods: 82 healthy blood donors and 79 AS patients were enrolled in this study. MIF 173 G/C polymorphism and CD 74 levels were investigated in the patient and control groups using the ELISA method. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Radiology Index (BASRI), Visual Analogue Scale (VAS) and Ankylosing Spondylitis Quality of Life (ASQoL) scores were calculated and recorded. Results: There was no significant difference between the patient and control groups in terms of age, gender, and body mass index. The median CD74 level of the patient group was 1.17 (0.93-2.1), which was significantly lower than that of the control group, i.e. 2.16 (1.6-4.41). There was no correlation between CD 74 antigen levels and BASDAI, BASMI, BASFI, BASRI, VAS and ASQoL scores. The number of patients who had the C allele was higher among the patients with AS in comparison to the control group; however, the difference was not statistically significant (p>0.05). There was no correlation between genotypes and BASDAI, BASMI, BASFI, BASRI, VAS and ASQoL scores (p>0.05). Comparison of the median CD74 levels of the individuals in the patient group according to their HLA-B27 status and genotypes did not reveal any statistically significant difference. Conclusion: The CD74 antigen levels of the patients with AS were significantly lower compared to the control group. This implies that CD 74 is a parameter that can be used in the diagnosis of AS. Although the C allele among the MIF 173 G/C polymorphisms was more frequently observed in the patient group, the difference was not statistically significant. Moreover, there was no significant relationship between CD 74 antigen levels and polymorphisms.
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Purpose: In our study the diagnostic role of HMGB1 levels measured in serum were investigated in prostatitis and prostate carcinoma diagnosis and in the differential diagnosis of these two diseases. Material Method: Patients followed up for histopathologically verified diagnosis of prostate carcinoma and prostatitis in 20142017 at the Urology Clinic were included. HMGB1 measurement in serum was performed with the ELISA method. Results: A total of 78 subjects were included in the study, consisting of 30 (38.5%) prostatitis patients, 25 (32%) prostate carcinoma patients and 23 (29.5%) healthy subjects. HMGB1 was detected as 11.9±2.6 (Range 6.7-18.4) ng/ml in the prostatitis group, 15.1±4.5 (Range 8.4-24.8) ng/ml in the prostate carcinoma patients and as 9.2±3.1 (Range 4.7-18.7) ng/ml in the control group. The difference between the groups were investigated using the Friedman test as HMGB1 did not show normal distribution. Significant difference was detected between the three groups (p<0.001). When the groups were compared in pair, significant difference was detected between the prostatitis group and the control group (p=0.001). Significant difference was again detected between the prostate carcinoma group and the control group (p<0.001). Significant difference was detected between the prostatitis group and the prostate carcinoma group (p=0.006). Measurement of serum total prostate specific antigen (tPSA) levels were conducted automatically with the electro chemiluminescent method. A moderate level of (r=0.276) but a highly significant (p=0.009) positive correlation was found between PSA and HMGB1. Conclusion: In our study we showed that high PSA and high HMGB1 were highly correlated. HMGB1 measured in serum could be a useful marker in the differentiation of prostatitis and prostate carcinoma, in the early diagnosis of suspected prostate carcinoma and that HMGB1 value was significantly high in prostate carcinoma patients.
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Mehmet Akif KAPLAN, Fethi YAVUZ, Vedat DAVUTOĞLU, Murat YÜCE, Yurdaer DÖNMEZ, Özge Özcan ABACIOĞLU
Mehmet Akif KAPLAN, Fethi YAVUZ, Vedat DAVUTOĞLU, Murat YÜCE, Yurdaer DÖNMEZ, Özge Özcan ABACIOĞLU
Objective: There are many factors associated with chorda tendinea rupture. The present study aims to investigate the role of Interleukin-6 (IL-6), total antioxidant activity (TAA), total oxidant activity (TOA) and tumor necrosis factor alpha (TNF- α) levels on the development of the mitral valve chordae tendinea rupture. Methods: Our study consisted of 30 patients with mitral chordae rupture, 30 patients with severe rheumatic mitral regurgitation, and 20 healthy participants who were admitted to our polyclinic unit. The participants do not have a previously known comorbid disease. After transthoracic echocardiography, their diagnoses were confirmed by the transesophageal echocardiography. Plasma IL-6, TAA-TOA and TNF-α level of all patients were measured and their oxidative stress index (OSI) was calculated. Results: Compared to the rheumatic severe mitral insufficiency patients and control group, TOA-OSI levels in the chordae rupture group were significantly higher (p=0.038 and p=0.019, respectively). The TNF-alpha levels in the rheumatic severe mitral insufficiency group were determined as statistically and significantly higher than the chordae rupture group (p=0.028). Conclusion: We have put forth that there is a significant relationship between the chordae rupture levels and oxidative stress levels (TOA-OSI) for the first time in our study. According to the results of our study, high oxidative stress might be accepted as a risk factor for chordae rupture. In addition, it has been observed that the TNF-α level in the rheumatic severe mitral insufficiency group have been higher than those in the chordae rupture group. It seems, these data support the role of inflammation in the rheumatic severe mitral insufficiency development.
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Objective: This study aimed to assess the efficiency of radiotherapy and evaluate its outcomes for elderly (>65 years) patients who have undergone treatment for nasopharyngeal carcinoma (NPC). Methods: Forty-five (male, 35; female, 10) elderly patients with a diagnosis of undifferentiated NPC who were treated at our institution between 1994 and 2012 were retrospectively evaluated. The primary endpoint was the relationship between the patients’ characteristics and overall survival (OS); progression-free survival (PFS), locoregional progression-free survival (LRPFS), and toxicity analysis were the secondary endpoints. Results: The patients had a median age of 74.2 years. At a median follow-up period of 64 months, the median OS, PFS, and LR-PFS were 45 (95% confidence interval [CI]: 5.887-84.113), 34 (95% CI: 0.0-70.504), and 45 (95% CI: 20.092-69908) months, respectively. The 2-, 3-, and 5-year OS rates were 61.5%, 53.1%, and 50.0%, respectively, and the 2-, 3-, and 5-year PFS rates were 57.6%, 46.8%, and 43.7%, respectively. Patients with T stage (T3-T4 vs.T1–T2) or N stage (N0–1 vs. N2) had significantly shorter OS (p<0.05), PFS (p<0.05), and LR-PFS (p<0.05) outcomes, respectively, which were also confirmed using a multivariate analysis (p<0.05). Conclusion: Our results demonstrated that the established prognostic factors, including T and N stages, were important prognostic indicators of NPC in elderly patients.
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Transverse colon volvulus is a disease that mostly occurs in the elderly and is rare in young people and children. Some of the predisposing factors for transverse colon volvulus are mental retardation, dysmotility disturbances, presence of narrow or long mesentery, and chronic constipation. One of the treatment options is endoscopic reduction, which is performed in patients whose overall condition is stable. It is not considered in case of emergency surgery. The success rate is low and the recurrence rate is high. Herein, we present the case of an 80-year-old female patient who was diagnosed with transverse colon volvulus as a rare cause of intestinal obstruction
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Objective: There is a balance among the free radical production and the antioxidant system suppressing the increase of reactive oxygen species in the body. If this balance is disturbed, then oxidative stress occurs. Free radicals caused by normal metabolism or pathological processes cause deterioration in the structure and functions of thiol-dependent enzymes and change in the thiol / disulfide balance in the cell environment. The aim of our study is to evaluate the dynamic thiol/ disulfide balance in children with acute malnutrition. Methods: The weight, weight Z score, height, height Z score and BMI of the patients in the study group were measured. 52 patients diagnosed with acute malnutrition according to Waterlow classification and 40 healthy children were included in the study. The thiol/ disulfide balance was measured in both groups by using the automatic method developed by Erel and Neselioğlu. Results: There was no statistically significant difference among patient and control group in terms of the average native thiol and total thiol levels. While it was found that the levels of disulfide, disulfide/native thiol and disulfide/total thiol were statistically significant in the patient group, the native thiol/total thiol ratio was found to be lower at a significant level. Conclusion: It was seen that thiol/ disulfide balance weakened in children with acute malnutrition and showed a shift towards disulfide.
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