Purpose: Ovarian ischemia, which is known as one of themost common gynecologic surgery emergencies in womenof all ages, is the distruption of the ovarian perfusion.Herein, we aimed to investigate the effect of tadalafil, aphosphodiesterase-5 inhibitor, at different doses anddurations in the management of ovarian survival inischemia-reperfusion injury model in rats. Materials andMaterials and Methods: Thirty female Wistar albino ratswere divided into five groups. Ovarian ischemia wasinduced by clamping the adnex of uterine tuba for threehours and reperfused for one hour. Drug treatments weregiven as follows: Group 1: saline (ischemic control), Group2: tadalafil 1 mg/kg, Group 3: tadalafil 10 mg/kg, Group4: tadalafil 1 mg/kg for 7 days, Group 5: tadalafil 10 mg/kgfor 7 days. At the end of the treatments, ovaries wereremoved and evaluated for histopathological analysis.Results: Group 4 and Group 5 showed significantdecrease in vascular congesion, hemorrhage, edema,neutrophilic infiltration compared to Group 1. All groupsshowed significant decrease in neutrophilic infiltrationcompared to Group 1. We found that treatment withtadalafil for 7 days significantly decreased the ovariantissue damage scores in rats compared to the ischemiccontrol.Conclusion: Our results showed that tadalafil treatmentin ischemic ovarian injury is effective in limiting ovariandamage. The reduction in the tissue damage scoressuggested that treatment with PDE5 inhibitors, such astadalafil, may contribute to the healing of conservativelytreated ovaries and may play a role in the treatment ofadnexal torsion
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Mahmut Selim ARPACIOĞLU, Zeynep BALTACI, Başak ÜNÜBOL
Mahmut Selim ARPACIOĞLU, Zeynep BALTACI, Başak ÜNÜBOL
Amaç: Araştırmamızda pandemi sürecinde sağlıkçalışanlarının tükenmişlik, mesleki doyum, depresyon,anksiyete, Covid-19 korkusu düzeyleri ve bunlarla ilişkilifaktörlerin incelenmesi amaçlanmıştır.Gereç ve Yöntem: Kesitsel ve tanımlayıcı tasarımda olanbu araştırma Covid-19 pandemi sürecinde aktif çalışmaktaolan ve araştırmaya gönüllü tüm sağlık çalışanlarınıkapsamaktadır. Pandemi tedbirleri nedeni ile elektronikortamda 371 sağlık çalışanının katılımı ile gerçekleşmiştir.Sosyodemografik bilgi formu, İş doyumu Ölçeği, MaslachTükenmişlik Ölçeği, HSA-4 Hasta Sağlığı Anketi, Covid19 Korkusu Ölçeği kullanılmıştır.Bulgular: Katılımcıların %73,6’sı devlette kadroluçalışmaktaydı ve %43,2’si doğrudan Covid-19 hastalarıylaçalışmaktaydı. Maslach Duyarsızlaşma, Covid Korku,HSAKaygı ve Depresyon ölçeklerine göre kadın gruportalaması, erkek grup ortalamasından anlamlı bir şekildefarklı ve büyüktü (p<0.01). Duygusal Tükenme, HSAtoplam ve Depresyon ölçeklerinde Bekar grup ortalaması,Evli gruptan anlamlı bir şekilde büyük bulundu. CovidKorku ve HSA ölçeklerinde Ebeveynlerimle ya daEşimle/Eşim ve çocuklarımla yaşıyorum diyenlerin gruportalaması, yalnız yaşayanlardan anlamlı bir şekilde büyüksaptandı.Sonuç: Pandemi döneminde sağlık çalışanlarında işdoyumunu artıracak ve tükenmeyi azaltacak şekilde çalışmaşartlarında düzenlemeler yapılması, yüksek riskli birimdeçalışanların daha yakından izlenmesi ve gerekli psikolojikdestek sağlanması önemlidir.
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Purpose: Electrocardiography (ECG) is the first-linediagnostic tool to evaluate cardiac involvement in anydisease and COVID-19 patients. The objective of thisstudy is to investigate the ventricular arrhythmia formingeffect of COVID-19 and to guide the treatment.Materials and Methods: A total of 74 patients (mean age52.63±17.85 years) under follow-up for asymptomaticCOVID-19 and 74 healthy volunteers (mean age50.71±6.02 years) were enrolled in the study. Heart rate,QRS duration, QT distance, T-wave morphology (Tp-einterval), Tp-e/QT ratio, and index of cardioelectrophysiological balance (iCEB) were analyzed andcompared to both groups.Results: The heart rate was higher, and the QT intervalwas shorter on ECG in the COVID-19 group. QTcinterval, Tp-e intervals, and Tp-e/QT ratio were notdifferent between groups. Furthermore, iCEB and iCEB-cvalues were not different between groups. A significantpositive but weak correlation was observed between CRPand troponin values in patients with COVID-19.Moreover, there was no correlation between troponinlevels and Tp-e/QT ratio and iCEB in patients withCOVID-19.Conclusion: The chronic cardiac effects of the COVID19 have not been elucidated. Prospective clinical trials withlong-term and a high number of patient populations areneeded to reveal this. Notably, patients with significantlyelevated troponin values should be followed up for longterm development of cardiomyopathy and arrhythmias.
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Purpose: The aim of this study was to compare theefficiency of laparoscopic and transvaginal meshoperations with conservative surgery of reproductive-agewomen with pelvic organ prolapse (stage≥2) (POP).Materials and Methods: In this study, we retrospectivelyevaluated 22 cases of 105 patients who diagnosed withsymptomatic POP-Q stage 2 and above pelvic prolapse,part of whom underwent laparoscopic surgery (Group-1)while the other part composed of those who underwenttransvaginal mesh (TVM) surgery (Group-2). Urogenitalprolapse Pelvic Organ was graded using POP-Q.As thecurrent TVM surgical kits four-arms mesh was used.Results: The mean age of the patients of both groups was42.2±11.4 and 38.3±12.8 years, respectively. The meanduration of hospitalization for the patients underwentlaparoscopy was 2.3 days (range:1-4 days), that period wasobserved as 3 days in Group-2 (range:2-4 days). None ofour patients had any adverse reactions in the early or latestages. The rate of success was 95.45% for patients whounderwent laparoscopic surgery, while it was 98.10% forthe group of TVM surgery.Conclusion: Transvaginal mesh surgery was found to bea relatively successful technique in pelvic organ prolapsesurgery owing to the high rate of success and minimal ratesof complications.
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Purpose: The aim of this study was to evaluate theimportance of C-reactive protein (CRP) and procalcitonin(PCT) in the diagnosis and monitoring of infections inchronic kidney disease (CKD) patients.Materials and Methods: In this study, 1538 hospitalizedpatients in the nephrology division of Ondokuz MayısUniversity between March 2012 and June 2014 wereevaluated. A total of 72 patients with CKD (Glomerularfiltration rate <60 ml/min), treated for any bacterialinfection and complete data were included. The laboratoryvalues before and after antibiotic treatments werecompared.Results: The median age of 72 patients was 66 (20-90)years, and 52.8% (n=38) were male. Primary reason forhospitalization was infection in 52.8% (n=38) of thepatients. There was a significant decrease in CRP and PCTafter infection treatment. CRP difference after treatmentwas significantly high in patients with positive culture.CRP, PCT and difference in PCT had no decision-makingfeature for the culture positivity, while the difference inCRP was determined to have a decision-making feature.Conclusion: CRP and PCT levels decreased significantlyin CKD patients after infection treatment, and weconfirmed that they are valuable markers in the diagnosisand follow-up of bacterial infections in CKD patients as inother patient groups. We found that the difference in CRPwas predictive for culture positivity while the difference inPCT was not. We found a higher than normal CRP cut-offvalue (12 mg/L) in CKD patients as an indicator ofinfection.
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Amaç: Tedavi uyumu psikotik bozukluklarda hastalıkgidişini belirleyen en önemli değişkenlerden birisidir. Buçalışmada yatarak tedavi gören psikotik bozuklukhastalarının taburculuk sonrası dönemde tedavi uyumlarıdeğerlendirilecektir. Aynı zamanda tedavi uyumlarına göresınıflandırılan gruplar arasında da karşılaştırmalaryapılacaktır.Gereç ve Yöntem: Mevcut çalışmaya 30.06.2018-30.06.2019 tarihleri arasında yatarak tedavi gören vehastaneden çıkış tanısı psikotik bozukluk olan 39 hastadahil edilmiştir. Hastalar taburculuklarından sonra telefonile aranarak mevcut durumları ile ilgili bilgi alınmıştır.Hastalarla yapılan bu görüşmede ayrıca Morisky TedaviUyum Ölçeği, Kısa İşlevsellik Değerlendirme Ölçeği veKlinik Global İzlenim Ölçeği doldurulmuştur.Bulgular: Çalışmaya dahil edilen hastaların 20’sinin (%51.3) tedavi uyumu düşük, 10’unun (% 25.6) tedavi uyumuorta ve dokuz hastanın (% 23.1) ise tedavi uyumu yüksekolarak bulunmuştur. Tedavi uyumu düşük olan hastalarıntaburculuk sonrası yeniden hastane yatışlarının daha sıkolduğu, işlevselliklerinin daha kötü olduğu ve hastalıkları ileilgili daha az bilgi sahibi oldukları tespit edilmiştir.Sonuç: Psikotik bozuklukta tedavi uyumundaki düşüklükhastalık seyrinin olumsuz olmasına neden olabileceği içintedavi uyumunu arttırmaya yönelik girişimler gerekebilir.
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Amaç: Bu çalışmanın amacı, maternal kandaki “cell-free”fetal DNA'dan paternal mutasyon tayini için nanopolimerbazlı genosensör ile yeni bir prosedür geliştirmektir.Gereç ve Yöntem: Kuvars-kristal mikrobalans (QCM) vebiyosensör teknolojilerini kullanılarak β-talasemi IVS1-110mutasyonun analizine uygulanmıştır. Bu amaçla,mutasyona ait problar genosensör elektrodu üzerinePoliHema-MAC nanopolimeri aracılığıyla bağlandı ve dahasonra örnekler tespit amacıyla çalışma hücresine eklendi.Genosensörün optimizasyon, karakterizasyon, duyarlılıkve özgüllük çalışmaları yapıldı.Bulgular: Biyosensör ölçümleri -0,6 - 0,8 V sabit akımaralığında döngüsel volatmetriyle elde edildi. Girişimselolmayan doğum öncesi tanı testi yapılan fetüslerde ARMSyöntemiyle ortak sonuçlar elde edilmiştir. ARMS sonuçlarıgenosensör sonuçları ile istatistiksel olarakkarşılaştırıldığında çizilen ROC eğrisinde %99 uyumlulukoranı elde edilmiştir.Sonuç: Geliştirilen biyosensör, yüzeyinde bulunan probaözgül olarak, fetüsün paternal mutasyonunun varlığınıortaya koyabilmektedir. Rutinde kullanılan gelenekselyöntemlerle karşılaştırıldığında, daha düşük maliyetli, hızlısonuç verebilen, özgüllüğü ve saptama etkinliği yüksekolarak bulunmuştur.
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Purpose: The aim of this study was to compare the clinicaland radiological results of paediatric tibia shaft fracturestreated by intramedullary fixation with Kirschner (K) wireand titanium elastic nail (TEN).Materials and Methods: Thirtynine patients wereevaluated retrospectively. Included 20 patients treated withTEN (group 1) and 19 patients treated with K-wire (group2). At the end of the 1-year follow-up, radiologicalmeasurements for malalignment and the Flynn TENoutcome scoring system were used to compare the clinicalresults.Results: According to the Flynn classification, in group 1,results were excellent in 75% and good in 25%, and ingroup 2, excellent in 70% and good in 30%. In any caseshas not been experienced physeal early closure orrefracture, nor did they need re-manipulation or reoperation, and no implant insufficiency was detected.Malalignment was found in four patients in group 1, andin two patients in group 2 of lesser than 10 degrees.Conclusions: Even though two methods showed similarclinical and radiological results, fixation paediatric tibialfractures with K-wire may have some advantages as lowercost and easy accessibility according to TEN.
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Purpose: Parkinson’s disease (PD) is a neurodegenerativedisorder characterized by both motor and nonmotorsymptoms mainly due to striatal dopamine deficiency.Cognitive dysfunction is one of nonmotor symptoms. Thepurpose of this study is to determine the cognitivedysfunction with practical screening tests and toinvestigate relationship between cognitive dysfunction andclinical severity in early stage of PD (EPD)Materials and Methods: EPD patients and healthycontrol group were included into the study. Mıni mentalstate examination (MMSE), digit span (DS), clock drawing(CD), verbal and visual memory tests were applied to allcases. Unified Parkinson’s Disease Rating Scale (UPDRS)and Hoehn & Yahr Staging (H&Y) tests were performedto EPD patients. Correlation of neurocognitive tests withUPDRS and H&Y scores were examined in EPD patients.Results: There were 30 EPD patients (11 female/19 male)and 20 healthy controls (10 female/10 male). There was asignificant difference only in CD test between EPD andhealthy controls. EPD with H&Y stage 1. group hadhigher score on backward DS, CD, and visual memorytests than EPD with H&Y stage 2. Verbal memory testscores had negatively correlated with UPDRS scores.Conclusion: The first impaired test was CD in EPDcompared to control group. Other cognitive tests(backward DS, verbal and visual memory tests) were alsoimpaired with increasing severity of disease. MMSE wasnot different from the control group and did not changewith increasing severity of disease. MMSE alone is notenough for evaluating of EPD, other cognitive tests haveto be used.
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Purpose: The aim of this study is to evaluate the effect ofeducation on rational drug use and health literacy in peoplewith diabetes mellitus.Materials and Methods: This pre-test and post-testcontrol group interventional study was conducted between24 January and 25 July 2020 in Zonguldak DiabetesAssociation in Turkey. The universe of the study consistsof 238 diabetic people registered to the association, andthe sample group consists of 154 diabetic people who wereregistered members of the association who had inadequateand problematic-limited health literacy according to thedata collected previously and other sample criteria. Groupsof 4-6 people created from the intervention group wereapplied face-to-face by the researcher with a power pointpresentations, an educational program that included basicknowledge of diabetes, rational knowledge of drug use andknowledge of health literacy. Data from the study werecollected using the Rational Drug Use Scale, the TurkishHealth Literacy Scale and Diagnostic Form. Interventionand control groups were established by randomizationmethod regardless of the evaluation results. After threemonths, assessments of groups were repeated.Results: In the evaluation of the intervention group in thethird month after the education, statistically significantchanges were determined in Rational Drug Use Scale scoreand Turkish Health Literacy Scale score.Conclusion: It was found that providing group-basededucation on general diabetes knowledge, rational drug useand health literacy to people with diabetes was effective inincreasing rational drug use and health literacy level.
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