Aim: Systemic inflammatory response syndrome may develop after coronary artery bypass graft surgery that performed by cardiopulmonary bypass technique. It is known that olmesartan, an angiotensin II receptor blocker, has anti-inflammatory effects. The antiinflammatory efficacy of olmesartan treatment was investigated in patients undergoing cardiopulmonary bypass.Materials and Methods: The study included 50 patients (14 female, 36 male) between 30-80 years of age were underwent CABG surgery. Patients were randomly assigned to control (Group C) and olmesartan (Group O) gruoups. Group O were treated with a single dose of 10 mg per day; 5 days preoperatively and 35 days postoperatively, 30 mg at the operation day. Samples were taken before the induction of anesthesia (T1), 5 minutes before cross clamping (T2), 5 minutes after cross clamping (T3), after protamine infusion (T4), postoperative day 3 (T5) and postoperative day 35 (T6) for total serum levels of IL-6, IL-10 and IL-18; for h-CRP levels preoperative (T1) and postoperative day 35 (T2).Results: Statistically significant decrease of CRP levels were observed on the postoperative 35th day in Group O (p<0.05). Statistically significant decrease of IL-6 levels were observed in the Group O after protamine infusion (T4) and postoperative 3rd day (T5) (p <0.05).There was a statistically significant increase at 5 min. after the cross declamping time (T3) for IL-10 levels (p<0.05).Conclusion: Although the anti-inflammatory efficacy of olmesartan has been proven, it can be accomplished by combining it with drugs that have anti-inflammatory effects like statins or dose increasing.
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Aim: For an efficient disease management and prevention of the development of complication, diabetic individuals are expected to establish a new life style right from the diagnosis. The perception of risk related to the disease has importance in the adaptation of the diabetic individuals to the new life style. The research is conducted to identify the perception of risk related to complications and it’s relation with metabolic parameters in diabetic individuals.Materials and Methods: This descriptive research was conducted in 237 diabetic individuals applied to a Diabetes Polyclinic of a university hospital. The data was acquired by patient identification form, The Risk Perception Survey–Diabetes Mellitus Scale and metabolic control variables form.Results: Individuals’ knowledge of the risk related to diabetic complications are at a good level while the perceived risk level is high. It is particularly confirmed that individuals perceive complications such as heart attack, high blood pressure and vision problems risky at a higher level. A positive correlation is established between the period of disease and risk knowledge, HbA1c level and worry, and fasting blood sugar and risk perception (p<0.01).Conclusion: In the study, it is determined that, despite the high level of risk knowledge related to complications, the diabetic management of individuals is not enough while the risk perception is high. It is confirmed that the risk perception of metabolic parameters is especially related to worry level.
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Aim: In this preliminary study, we aimed to investigate the effect of sulforaphane (SFN) warm ischemia in a non-heart beat rat liver model (NHBD). Materials and Methods: Livers taken from NHBD 15,30,60 min after warm ischemia were stored up at University of Wisconsin solution for 5 h at 40C [cold storage (CS)] and were, then, exposed to 2 h of machine reperfusion (MRP) at 370C. In the study group, SFN 5 mg/kg was intraperitoneal given 30 min before the introduction of NHB. Firstly, we divided the rats into the control and SFN groups. Then, each group was divided into three groups (n=10 in each) including control I, II, III and SFN I, II, III groups (15-, 30-, and 60-min warm ischemia period, respectively).Control and study groups at the same time of ischemia were compared with each other in terms of lactate, AST, ALT, IL-6, TNF-α and morphologically.Results: In the group treated with SFN, AST, ALT, TNF-α, IL-6, and lactate levels were lower, compared to the control group. Histopathologically, Bcl-2 staining intensity and percentages of staining were statistically significant, compared to the control and study groups during 15-min warm ischemia. Although not statistically significant, the intensity and percentage of staining were higher at 30 min and identical at 60 min. Conclusion: Our study results suggest that, despite prolonged warm ischemia time, SFN can biochemically and morphologically protect the liver from the hazardous effects of ischemia reperfusion in an experimentally-controlled NHB in rats, indicating an increased utilization rate of NHBDs.
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Aim: The medical records of 68 patients diagnosed with severe ACC and treated with PC at Başkent University Faculty of Medicine, General Surgery Clinic between January 2011 and January 2018 were retrospectively analyzed.
Results: Among patients who underwent PC for severe ACC at our clinic, 39 (57.4%) were male. Their mean age was 71.7 (28-94) years. All patients had pain; 13 (19.1%) patients had nausea-vomiting; 8 (11.8%) had had fever. The mean time from symptom onset to hospital admission was 6.2 (1-30) days; the mean time from admission to PC placement was 2.1 (1-9) days. Twelve (17.6%) patients had minor complications due to cholecystostomy catheter. Twenty seven (39.7%) patients underwent cholecystectomy with a mean of 83.1 (20-705) days after cholecystostomy placement. Seventeen of these patients underwent laparoscopic surgery and 3 of them converted to open surgery. In 5 of 41 patients who did not undergo cholecystectomy, AC recurrence developed (12.2%) and PC was inserted again. Five (7.4%) patients died.
Conclusion: Percutaneous cholecystostomy catheter is an effective treatment to control inflammation until cholecystectomy among high-risk patients diagnosed with severe cholecystitis and may be a definitive therapy for patients unable to undergo surgery.
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Aim: Hereditary breast cancer is one of the components of hereditary breast-over cancer syndrome (HBOC) that results with multiple cancer predisposition. Heterozygous mutations of BRCA1 and BRCA2 that have crucial roles in DNA repair are responsible for about 12-25% of the patients. 25 different genes have been identified to be a causal factor in the patients whose BRCA tests are negative. Most of these genes are involved in functionally related genome maintenance pathways with BRCA1 and BRCA2. We aimed to investigate genes other than BRCA1/2 to determine breast cancer etiology. Materials and Methods: Of the 230 patients diagnosed with breast cancer, 38 patients with no mutation in BRCA1 / 2 were evaluated. Hereditary breast cancer panel was designed with QIAseq solution. The sequencing process was performed on the Illumina MiSeq system. The data analyses were performed on QIAGEN Clinical Insight analyze software. Results: The genes associated with hereditary breast cancer were studied with the new generation sequencing method in 38 of the patients without pathogenic or VUS variants. Pathogenic/likely pathogenic variants were detected in 3 (7.8%) of 38 patients, while VUS was detected in 10 (26.3%) patients. Of these 22 genes, c.312C>A (p.Tyr90Ter) in MUTY, c.1225C>T (p.Arg409Trp) in STK11, c.1690C>T (p.Gln564Ter) variant in BARD1 interpreted as pathogenic.Conclusion: Our data provide insight into the genetics of HBOC syndrome in Turkey. These studies will help to improve the clinical management and better risk assessment of hereditary breast and ovarian cancer.
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Aim: The objective of this study is to evaluate the clinical series of patients who underwent vertebral augmentation surgery in Neurosurgery department of Baskent University. Materials and Methods: The medical data stored in electronic and print files were retrospectively analyzed and patients operated in recent past were called for evaluation of outcome. Results: One clinical; pain relief and two radiologic, kyphotic angle and vertebral compression, criteria were used to evaluate the final outcome. The statistical analysis revealed that in all three parameters there was significantly important improvement in postoperative values. Procedure related complications were minor. No permanent neurologic deficit or mortality was seen. Conclusion: Both vertebral augmentation techniques are simple, effective and safe procedures provided that surgical indications are correct and surgical technique is properly carried out.
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Aim: It was aimed to investigate the relationship between fatty tissue thickness in the medial of the knee and degenerative meniscus lesion.Materials and Methods: Images of 300 patients (151 females and 149 males) who had previously taken knee magnetic resonance imaging (MRI) were evaluated retrospectively. The relationship between medial meniscus degenerative lesion (MMDL) and age, sex, side, height, weight, body mass index (BMI), medial fat thickness (MFT), length of medial tibial plateau (MTP) was investigated.Results: Mean age of 300 patients (144 rights, 156 left knees) was 41.4 ± 11.8 (range 18–67) years and 200 of them had degenerative meniscus lesions, 100 of them were not detected.Age, weight, height, BMI, MFT, MTP, and MFT/MTP were all correlated with the presence of an MMDL, and the strongest relationship was with age (p<0.001). No significant relationship between weight and MMDL was found. However, both MFT and the MFT/MTP ratio were more strongly correlated with the presence of an MMDL. Logistic regression analysis indicated that the presence of an MMDL was 25 times more likely in patients with a high MFT/MTP ratio (odds ratio, 0.040).Conclusion: In this study, the MFT / MTP ratio was found higher in patients with medial meniscus degenerative lesions than in the healthy population. This study shows that fatty tissue thickness in the medial of the knee can be effective in the formation of degenerative meniscus lesions, as well as BMI. However, this study may form the basis for prospective studies in which factors such as daily activity, profession and sports level are also investigated to create a clearer judgment.
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Aim: Atherosclerosis begins from an early age and manifests in later years as Coronary artery disease (CAD). This inflammatory process is aggravated by age, smoking, hypercholesterolemia, hypertension, diabetes mellitus, and genetic factors. We aimed to investigate which isoform of APOE is related to extensive coronary lesions in patients with stable coronary heart disease.Materials and Methods: This study was carried on single center. One hundred and ten patients diagnosed with stable coronary artery disease by coronary angiogram were enrolled consecutively. Syntax score was calculated by a tool of website calculator (www.syntax.com). According to the Syntax score, patients were split into three groups. APOE genotyping was performed through blood samples. Patients split into three groups according to the APOE genotypes: E4 (3/4 and 4/4 genotypes), E3(3/3 genotype), E2 (2/2 and 2/3 genotypes). APOE groups were compared according to baseline characteristics and syntax scores.(%82.6) değil (82.6%) olacak. Lütfen İngilizce kurala göre düzeltiniz. Tüm sayısal değerlerde virgülleri de nokta yapmayı unutmayınız.Results: Coronary angiography and APOE genotypes of 98 patients were analyzed. 81 of patients (%82.6) had E3E3 allele; 6 of patients (%6.1) had E2E3 allele; 10 patients (%10.2) had E3E4 allele and 1 patient (%1) had E2E4 allele. Due to the contrast effect of E2 and E4 on CAD, we excluded patients with E2E4 allele from the study. Firstly, we assessed distribution of APOE genotype E2 (E2E3), E3 (E3E3 and E3E4), E4 (E3E4) within 3 groups of syntax scores. Total of 6 patients of E2 allele was at low syntax score group. 83 patients of E3 allele were at the low-risk group of syntax score. 10 patients of E3 allele were at the mid group and 4 patients were at the high-risk group of syntax score. 7 patients of E4 allele subjects were at the low-risk and 1 patient was at the high-risk group of syntax score. Compared to syntax score groups and APOE genotypes, E2 alleles were in lower syntax score group versus E3 (P=0.046) and E4 (P=0.003) alleles. However E4 alleles were in higher syntax score group versus E3 alleles (P= 0.034). The Syntax score was seemed to be lower in the E2 allele group versus E4 and E2 groups (P=0.013).Conclusion: we reported the first study that E2 allele was related with less and E4 allele was more extensity and severity of CAD in patients with stable ischemic coronary disease.
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Aim: The aim of the study is to examine the job and life satisfaction levels of academicians and determine the relationship between job and life satisfaction. Materials and Methods: The sample of this cross-sectional descriptive study consisted of 338 academic staff (health, social) working at Manisa Celal Bayar University between November 2018 and June 2019. Data were collected via Information Form, Life Satisfaction Scale (LSS) and Job Satisfaction Scale (JSC). Data were analyzed using number, percentage, Kruskal Wallis H test, Student t test, One way ANOVA test, Spearman Correlation Analysis and Linear regression analysis. Results: According to the results of the correlation analysis, there was a high positive correlation (rs: 0.608) between the total score of LSS and JSC of academicians. According to regression analysis, it was seen that disease condition, mobbing and physical conditions satisfaction variables explained 15% of LSS score variance. Also, it was seen that disease condition, working year in the institution, managerial duties in the institution, mobbing and physical conditions satisfaction variables explained 36% of JSS score variance. Conclusion: Job and life satisfaction of academicians positively affects each other. Another important result, disease condition, mobbing and satisfaction with physical conditions, is very important for both the job satisfaction and life satisfaction of individuals.
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Aim: To compare IVF-ICSI outcomes in single-versus-double lumen oocyte retrieval needles in patients diagnosed with unexplained infertilityMaterials and Methods: A total of 188 patients aged 23-33 years who were diagnosed as unexplained infertility and underwent IVF/ICSI treatment were included and divided into two groups according to whether the catheter used in oocyte collection was single or double lumened: group 1 patients with single lumen (n: 59) and group 2 patients with double lumen (n:129). In addition, patients were divided into two subgroups according to the treatment protocol: antagonist protocol (n:134; 45 patient in group 1 and 89 patient in group 2) and long agonist protocol (n:54; 14 patient in group 1 and 40 patient in group 2). Results: Implantation rate (32.2% vs. 48.1%, p:0.042) clinical pregnancy rate (25.4% vs. 41.9%, p:0.03) and live birth rate (17.2% vs. 28.6%, p: 0.011) were higher in patients to whom double-lumen was used. According to multivariate logistic regression analysis, double lumen use was found to be an independent predictor for clinical pregnancy (p = 0.041). According to the treatment protocol; clinical pregnancy rates (15 (25.4%) vs. 54 (41.9%), p: 0.011) and live birth rates (8 (13.6%) vs. 40 (31.0%), p: 0.030) of patients to whom double lumen was used during oocyte pick-up after the antagonist protocol were significantly higher. Conclusion: Our study showed that the use of double lumen increased implantation rate, clinical pregnancy rate and live birth rate and it is evaluated as an independent factor that increases IVF/ICSI outcomes.
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