Abstract
Aim: We aimed to investigate the relationship between oxidative parameters- total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI)- and EFT in patients with CSX. Without clinically significant coronary artery disease, cardiac syndrome X (CSX) is characterized by cardiac ischemia, and chest pain. However, there is some evidence about increased oxidative stress in CSX patients; the relationship between oxidative stress parameters and epicardial fat thickness (EFT) is not well established in this population.
Material and Methods: : One hundred and twenty-two patients with normal coronary arteries (73 female, 49 males, mean age 56.71 ± 10.69 years) were enrolled in the study. The study population was divided into two groups according to their OSI. Oxidative stress index below the median was defined as the OSI low group and equal or higher than the median was defined as the OSI high group.
Results: EFT was higher in the high OSI group than the low OSI group (6 (3.9 – 8.9) vs. 5.4 (0.56 – 7.2), p= 0.032). In bivariate correlation analysis EFT was positively correlated with OSI and TOS (r=0.242, p=0.036 and r=0.234, p=0.025 respectively). In binary logistic regression analysis, EFT was found to be an independent predictor of OSI.
Conclusion: : In our study, EFT was independently associated with OSI in CSX patients. This finding suggests that EFT may be a marker of increased oxidative stress in CSX.
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Abstract
Aim: Dyssynchrony can be seen in some patients with heart failure. The goal of cardiac resynchronization therapy (CRT) is the correction of dyssynchrony. The correction of myocardial loading and remodel-ing prevents development of the myocardial fibrosis. The aim of this study is to evaluate myocardial fibrosis markers in patients with heart failure CRT applied and to assess the relationship between these markers and dyssynchrony.
Material and Methods: Fifty one patients (ejection fraction (EF) ≤ % 35, QRS duration ≥130 msec) were included into the study. Electrocardiography (ECG), 6 minute walking test, and echocardiography were applied before and 6 months after CRT to all patients. Furthermore, Type I Collagen C-Terminal Propeptide (PICP), Type I Collagen C-Terminal Telopeptide (ICTP) levels and PICP/ICTP ratio were studied as myocardi-al fibrosis markers in blood samples.
Results: It is observed that QRS was shortened after CRT (p=0.0001). Six minute walking distance was in-creased 6 months after CRT (p=0.0001). PICP level measured before CRT as 560.2 ± 300.4 µg/L while it is measured as 476,9±285,8 µg/L 6 months after CRT (p=0.004). PICP/ICTP ratio before and 6 months after CRT was 9.7 ± 10 and 37.1 ± 32.8 respectively (p=0.0001). It is determined a negative relationship between EF and PICP level and PICP / ICTP ratio (p=0.008, r = -0.37).
Conclusion: Our results show that CRT reduces the left ventricular dyssynchrony and consequently leads to favor-able changes in myocardial fibrosis markers. Reducing the mechanical stresses on left ventricle and returning of consequent remodeling may be one of the important mechanisms in the prevention of cardiac fibrosis.
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Abstract
Aim: The aim of this study was to investigate the maximum Von Misses stress values of implants with different diameters in patients with different bone densities depending on the forces that are applied with different angles to the bone around the implant neck and implant surface, by using finite element analysis method.
Material and Methods: 3.8 mm and 4.6 mm diameter dental implants of an implant system that had an in vitro laser-microtextured neck design were used in this study. Computational models were generated for implants with different diameters which were placed in the maxillary and mandibular 1st molar teeth using flat and oblique (20°angled) abutments. Vertical and oblique (30°angled) forces of 300 N were applied to all models and the results were evaluated by finite element analysis.
Results: The results show that both vertical and oblique forces on the implants and placement of abutments in the flat and oblique position caused tension in the bone around the neck of the implant and the implant surface. When the oblique and vertical loads applied to the bone models were compared, the forces applied in the oblique direction exhibited a significant increase of Von Misses stress values in the cortical bone around the crest module of the implant compared to the other group. In our study, the minimum stress distribution with respect to the direction of the applied forces and placement positions of the abutments was obtained by applying the implant and the force in the same direction (abutment straight, force vertical). However, in the groups with the angled application of the force direction and the angled placement position of the abutments, the maximum Von Misses stress value
increased in the bone around the implant neck and implant surface.
Conclusion: Placing the implants at the right angle and within bone tissues with adequate cortical bone density around the implant will ensure minimal stress values on both the supporting bone and the implant surface.
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Abstract
Aim: Carpal tunnel syndrome (CTS) is a compression neuropathy. There is neuropathic pain in the clinic. Treatment is planned according to electrodiagnostic testing (EDX) and symptom severity. This study was planned to evaluate of full cup test (FCT) to demonstrate symptom severity in CTS and investigate the relationship between FCT and EDX.
Material and Methods: This study included patients with idiopathic CTS. The self-administered Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) and FCT were used to determine the severity of clinical symptoms. The severity of CTS was classified as mild, moderate and severe according to EDX.
Results: A total of 97 hands (55 right, 42 left) were evaluated. 29 patients had bilateral symptoms. The severity of CTS was 51.5% mild, 44.3% moderate, and 4.1% severe. The mean FCT score was 51.13 ± 20.80 (min: 6.6-max: 100). The mean symptom severity scale (SSS) of the BCTQ was 24.25 ± 7 and the functional severity scale (FSS) was 13.26 ± 4.55. The score of FCT was significantly
correlated with SSS and the FSS (r=0.60 p <0.001, r=0.65 p <0.001). Significant correlation was observed between FCT and EDX (r=0.57, p=0.001).
Conclusion: FCT can be used to assess the severity of neuropathic pain in CTS and may be a guide in planning treatment.
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Haldun ARPACI
Haldun ARPACI
Aim: The aim of this study was to evaluate new and current inflammatory markers in women with polycystic ovary syndrome (PCOS)
and to clarify the role of these markers in the etiopathogenesis of PCOS.
Material and Methods: This retrospective study included 97 women with PCOS and 124 body mass index-matched controls without
PCOS. The parameters examined as new and current markers in both groups were the monocyte-to-high density lipoprotein
cholesterol (HDL-C) ratio, high sensitivity C-reactive protein/ albumin ratio, systemic immune-inflammation index, inflammatory
prognostic index, prognostic nutritional index, white blood cell count, mean platelet volume, platelet distribution width, plateletcrit,
neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, triglycerides to HDL-C ratio and the lipid accumulation product index.
Results: No significant difference was found between the PCOS and control group in respect of inflammatory markers. The age and
follicle-stimulating hormone values of PCOS patients were found to be lower than those of the control group. Luteinizing hormone,
free androgen index, insulin and the homeostasis model assessment of insulin resistance values of PCOS patients were significantly
higher than those of the control group.
Conclusion: In terms of inflammatory parameters, no significant difference was determined between patients with PCOS and the
control group. Chronic inflammation may be multifactorial in PCOS and there is a need for studies with larger sample sizes to be able
to explain the exact role of inflammatory markers in PCOS etiology
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Aim: Oral etoposide dosage is roughly 50-100 mg/m2 on days 1 to 21 every 28 days. However, dosage of 50 mg/day oral etoposide
for five days a week is not well published. The present study, aimed to evaluate the efficacy and toxicity profile of low dose oral
etoposide regimen (50 mg/day on days 1 to 5 every week) in platinum-resistant epithelial ovarian cancer (EOC).
Material and Methods: This study retrospectively evaluates patients with pathologically confirmed platinum-resistant EOC who were
unable to tolerate the standard oral etoposide regimen and were on low dose (d1-5/7) oral etoposide regimen in third line or beyond
within the period between 2006 and 2014.
Results: The overall response rate among 33 EOC patients was 15.1% while clinical benefit rate was 42.4% (stable disease in 27.3%
and partial response in 15.1%). Median progression-free survival was 4 months (95% confidence interval [CI], 2.8–5.1 months) and
median overall survival was 12 months (95% CI, 8.8–15.1 months).
Conclusion: We concluded that low dose oral etoposide (50 mg/day, on days 1 to 5 every week) was effective and well tolerated for
platinum-resistant EOC.
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capacity. Thus, preoxygenation should be administered to every patient before anesthesia induction since airway management
may unexpectedly be difficult. Applying positive airway pressure is reported to improve preoxygenation. In this study, we aimed to
investigate the effect of applying positive pressure via the adjustable pressure limiting valve (APL) on preoxygenation.
Material and Methods: 40 patients aged from 18 to 80 years to be operated under general anesthesia were included in this prospective
randomized controlled study. The patients were randomly divided into two groups and preoxygenation was administered with
anesthesia facemask in the supine position using two different techniques. In both techniques, the anesthesia circuit was flushed
with O2
flush for 30 seconds and then preoxygenation was performed with 100% oxygen and 12 L/min of fresh gas flow for 3 min
in spontaneous breathing. In Group APL the APL valve was set at 5 cmH2
O pressure position. In Group SB, the APL valve was set at
open (spontaneous) position.
Results: The percentage of patients with an FeO2
of ≥ 90% at 3rd min was higher in Group APL than in Group SB (75% vs 40%, p=0.006).
The mean FeO2
value at 3rd min was statistically significantly higher in Group APL (89.6 vs 88.2, p=0.001). The degree of the difficulty
of the technique was reported to be higher in Group APL.
Conclusion: In conclusion, we have shown that applying 5 cmH2
O positive pressure by APL valve improved preoxygenation compared
with spontaneous breathing.
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Aim: Children requiring intensive care in the neonatal period have more fine motor injuries, learning difficulties, eating disorders and
sleeping problems. Sleep disorder rate is about 10-30% in children who had no problem in newborn period. We aimed to investigate
the rate of sleep disorder in children who were hospitalized in the neonatal intensive care unit during the neonatal period.
Material and Methods: Fourty-six patients hospitalized in neonatal intensive care unit and still followed in outpatient policlinic at
Çukurova University were enrolled in to the study. Children’s Sleep Habits Questionnaire was performed to evaluate sleep resistance,
delay in fall into sleep, duration of sleep, sleep anxiety, parasomnia, midnight awakening and daily sleepiness.
Results: Children were 6.64±1.18 years old. They were healthy and had no neurological sequela. None of the parents complained
about sleep disorders. However, 20 of the 46 (43.47%) children had sleep disorder (Sleep disorder group). Twenty-six children had
no sleep disorder (No sleep disorder group). There isn’t any statistically difference between the groups that terms of gestational age,
birth weight, ventilator support, gender (p>0.05).
Conclusion: Although there isn’t any significant difference between groups, sleep disorder rate is higher compared to normal
population’s rates reported in the previous studies. Infants discharged from neonatal intensive care unit should be under evaluation
also for sleep disorder.
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Aim: Rapid advances in technology cause children to become acquainted with technological products at an earlier age. Today’s
children and adolescents, called the Generation Z, use digital technology effectively. Video game addiction can affect mental health
in the next generation of children and adolescents and lead to aggressive behavior. The aim of this study was to identify the effect
of game addiction on reactive proactive aggression in secondary education students.
Material and Methods: The data of the research, which was patterned by the relational screening method, was collected from
secondary education students who attended high schools in Malatya city center. The sample group consists of 192 secondary
education students who were randomly selected from within the population. The data of the study was collected through “The Game
Addiction Scale for adolescents” and “Reactive-Proactive Aggression Scale (RPAS)”. Independent Groups t test, ANOVA and Linear
Regression Analysis were used in the analysis of the data.
Results: The study found that gender has a significant effect on reactive proactive aggression. Aggression levels of male adolescents
were significantly higher than females. Aggression levels of adolescents in the 10th grade were found to be higher than those of the
adolescents in the other grades.
Conclusion: According to the research results, game addiction accounts for 53% reactive-proactive aggression.
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hardware and software development by way of vagal complex management. We wonder if thyroid architecture and functions are
regulated by vagal nerve.
Material and Methods: The animals were divided to three groups according to their T4 hormone levels which 1.89±0.10 µg/dl values
was accepted as normal (G0; n=12); 2.13±0.19 µg/dl values was accepted as hyperfunctioned (GI; n=7) and 1.61±0.09 µg/dl values was
accepted as hypofunctioned (GII; n=5). All of the thyroid glands, thyroidal branches of vagal nerves and brainstem section at the level
of motor nucleus of vagal nerves sections were stained with haematoxylin-eosin, GFAP and tunnel dye for histological examination.
All microscopical Stereological evaluations were done to understand how vagal morphology effects thyroid tissue architectures and
T4 levels. All of the thyroid glands, thyroidal branches of vagal nerves and vagal motor nucleus evaluated stereologically to recognise
whether some histomorphological variations thyroid follicles and volumes per cubic centimeter compared with thyroid hormone
levels statistically.
Results: The mean neuron density of vagal nucleus (NDVN), axon density of thyroidal branches of vagal nerves
(TBVN), TFV, and T4
levels were measured as G0;GI and GII consequtively: (312±91)x$10^6/mm^3$
, 19.543±2.321/$mm^2$
,
1.89±0.10 µg/dl and (296±72)x$10^6\mu m^3/cm^3$
in G0; (387±93)x$10^6/mm^3$
, 22.576±2.864/$mm^2$
, 2.13±0.19 µg/dl and (331±65)
x$10^6\mu m^3/cm^3$
in GI and (245±56)x$10^6/mm^3$, 12.432±1.234mm2
, 2.13±0.19 µg/dl and (231±45)x$10^6\mu m^3/cm^3$
in GII.
Conclusion: It seems that decrased hormone levels due to ineffective/unadequate thyroid gland development results from
inadequately developing vagal complex architecture.
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