Ayat ARJMAND, Bahram ABEDİ, Seyed Ali HOSSEİNİ
Ayat ARJMAND, Bahram ABEDİ, Seyed Ali HOSSEİNİ
Objective: Nowadays, the use of energetic substances has become a complex problem in sports, such thatthe role of anabolic-androgenic steroids is undeniable. This study aimed to investigate the antiapoptotic effectof resistance training and Tribulus terrestris in the heart tissue of rats exposed to stanozolol.Materials and Methods: 35 rats divided into 7 groups including (1) sham , (2) stanozolol-treated, (3)stanozolol+50 mg/kg Tribulus terrestris-treated, (4) stanozolol+100 mg/kg Tribulus terrestris-treated, (5)stanozolol+resistance training-treated, (6) stanozolol+resistance training+50 mg/kg Tribulus terrestris-treated, and (7) stanozolol+resistance training+100 mg/kg Tribulus terrestris-treated. During 8 weeks, groups 2-7received 5 mg/kg stanozolol per day peritoneally; groups 5-7 performed resistance training for 3 sessions perweek; and groups 3, 4, 6 and 7 received daily doses of Tribulus terrestris peritoneally.Results: Stanozolol administration significantly increased the BAX, BCL-2, P53, and caspase 3 and BAX/BCL2 ratio (P < .001). Resistance training, 100 mg/kg Tribulus terrestris administration, 50 mg/kg Tribulus terrestrisadministration, resistance training+100 mg/kg Tribulus terrestris administration, and resistance training+50mg/kg Tribulus terrestris administration significantly decreased BAX, BCL-2, P53, and caspase 3 levels andBAX/BCL-2 ratio (P < .001); however, stanozolol+resistance training+100 mg/kg Tribulus terrestris administration caused more decrease than stanozolol+resistance training+50 mg/kg Tribulus terrestris administrationin BAX (P < .001).Conclusion: Resistance training and Tribulus terrestris administration alone appear to have antiapoptotic effects; however, resistance training combined with Tribulus terrestris administration, especially at higher doses,have more desirable effects than resistance training or Tribulus terrestris administration alone on the apoptosismarkers.
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Özgür ÇELEBİ, Demet ÇELEBİ
Özgür ÇELEBİ, Demet ÇELEBİ
Objective: This study aimed to report viral respiratory pathogens during the coronavirus disease 2019(COVID-19) pandemic.Materials and Methods: Other viral pathogens were identified. COVID-19 immunoglobulin M and immunoglobulin G were detected.Results: Of the 56 samples collected from women, 2 (3.5%) were positive for severe acute respiratorysyndrome coronavirus 2 (SARS-CoV-2), whereas 8 (10%) of the 80 samples from men were positive forSARS-CoV-2. The number of respiratory syncytial virus-A–positive cases was 6 (10.7%) in women and 14(17.5%) in men. Two (3.5%) of the women were positive for parainfluenza-3, and 6 of the men were positivefor influenza-B. The number of human metapneumovirus (HMPV)–positive women and men was 6 (10.7%)and 6 (7.5%), respectively. Rhinovirus caused 14.2% and 10% of the cases in men and women, respectively.With a ratio of 10.7% in women and 7.5% in men; SARS-CoV-2, with a ratio of 10% in men and 3.5% inwomen; influenza-B, with a ratio of 7.5% in men; and parainfluenza-3 and 4, with a ratio of 3.5% in women.SARS-CoV-2 had a mean incidence rate of 7% in men and women. The antibody screening results reveal thatantibody formation did not occur in 3 women among the 10 patients who were diagnosed with COVID-19,and antibody formation occurred in 2 of 7 men. Antibody formation occurred in 5 women (16.6%) and 7men (20.5%) among the 58 patients who were positive for other respiratory tract pathogens. However, 23(29.5%) of the blood samples collected from 78 individuals who were negative for the COVID-19 agent andother respiratory tract viral pathogens were positive for the COVID-19 antibody.Conclusion: Because the climate is colder than normal in areas settled at higher altitudes, more than onepathogens act together. In addition, respiratory infections are seen in all seasons. This causes the diseases tobe fewer and milder than in other regions.
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Yaşar KESKİN, Gökhan KOZ, Kemal NAS
Yaşar KESKİN, Gökhan KOZ, Kemal NAS
Coronavirus disease 2019 is a respiratory infection caused by severe acute respiratory syndrome coronavirus2. Coronavirus disease 2019 leads to the rapid activation of innate immune cells, particularly in patients withsevere disease. Psoriatic arthritis is a heterogeneous chronic inflammatory disease characterized by the association of psoriasis and arthritis. Similar to those with other viruses, patients with psoriatic arthritis are ata significant risk of infection with severe acute respiratory syndrome coronavirus 2. Patients with psoriaticarthritis are immunosuppressed owing to immune dysregulation during the active disease period or owing toimmunosuppressive drugs administered during remission, and they are prone to infections. The severe acuterespiratory syndrome coronavirus 2 is a threat to millions of people globally owing to the decline in immunityand because a significant number of people develop severe illness. In the period of coronavirus disease 2019pandemic, we briefly present recommendations for the treatment of psoriatic arthritis. In this review, webriefly address the management options and treatment recommendations for patients with psoriatic arthritisduring and after the coronavirus disease 2019 pandemic in light of recent scientific publications.
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Kimberly HALL, Fuhbe MFONE, Michael SHALLCROSS, Vikas PATHA
Kimberly HALL, Fuhbe MFONE, Michael SHALLCROSS, Vikas PATHA
Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there has been substantialprogress in the pharmacologic treatment and supportive care of patients hospitalized with active COVID-19infections. To date there have been numerous medications trialed for COVID-19 management. In this review, our objective is to provide a comprehensive review of the primary literature and clinical applicationssurrounding some of the prominent drugs and medication classes that have been utilized in those sufferingfrom COVID-19 infections. The medications reviewed in this article include: hydroxychloroquine, remdesivir, azithromycin, dexamethasone, melatonin, tocilizumab, ascorbic acid, and zinc. The medication classesreviewed include: anticoagulation, angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, convalescent plasma, non-steroidal anti-inflammatory drugs, human recombinant soluble ACE2, and theBNT162b2 mRNA COVID-19 vaccine.
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Mishu MANGLA, Ruchira NAUTİYAL, Nadia SHİRAZİ, Banishree PATİ
Mishu MANGLA, Ruchira NAUTİYAL, Nadia SHİRAZİ, Banishree PATİ
Decidual change is a key process required by the uterus to make itself ready for implantation. Presence ofectopic decidual tissue outside the uterine cavity is known as deciduosis.The clinical presentation can varyfrom being totally asymptomatic and subtle to presenting in the form of life-threatening emergencies likehemoperitoneum, recurrent pneumothorax, or even bowel perforation. Here, we present a case of ectopicdeciduosis of cervix presenting in the form of severe life-threatening antepartum hemorrhage in secondtrimester of pregnancy.
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Objective: Bipolar disorder (BPD) is a psychiatric condition that often manifests together with Axis-I
comorbidity. Comorbidity of psychiatric disorders influences the recognition, prognosis, and treatment of
the disorder, posing difficulties for the patient and physician. This study aims at identifying Axis-I comorbidities
and their characteristics in patients with BPD.
Materials and Methods: This retrospective study included 255 patients diagnosed with BPD according to the
DSM-IV. Comorbidities were determined using the SCID-I, a semistructured sociodemographic data form
developed by the authors, and a mood chart assessing clinical aspects. The patients were divided into 2
groups, those with and without comorbidity, and compared.
Results: Out of these 255 patients, 35% was found to have a current and 84.3% a lifelong comorbid
psychiatric disorder. About 33.1% of these patients had 1, 11.3% had 2, and 8.8% had more than 2
comorbid disorders. At least one comorbid anxiety disorder was found in 38.7% of the patients.
Obsessive and compulsive disorder (OCD) being the most common comorbid psychiatric disorder,
followed by social anxiety disorder (SAD), posttraumatic stress disorder (PTSD), and generalized anxiety
disorder (GAD). Comparing the clinical parameters between the 2 groups due to the presence of psychiatric
comorbidity in the BD patients, there were statistically significant differences in terms of the number of
depressive episodes (P = .041) and mania/hypomania (P = .048), and the need for antipsychotic monotherapy
(P = .007) and antidepressants (P = .001) for prophylaxis between the 2 groups.
Conclusion: Axis-I psychiatric disorders and particularly OCD and anxiety disorders accompanying BPD
prevail at a high rate. The presence of comorbid psychiatric disorder in BPD may negatively affect the clinical
prognosis of the condition; therefore, this area requires more study and careful investigation.
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Objective: Atrial fibrillation (AF) is the most commonly encountered arhythmia in clinical practice and
constitutes one-third of the hospitalizations related to cardiac dysrhythmia. Furthermore, it is the most
common reason for hospital admissions involving dysrhythmia complaints and is associated with the decrease
in quality of life, functional capacity, cardiac performance, and lifespan.
Materials and Methods: This methodological study, which aims to assess the validity and reliability of the
JAKQ, was conducted with patients (n = 175) who were admitted to the emergency clinic of Atatürk
University Research Hospital between December 2016 and June 2018 and who were diagnosed with atrial
fibrillation and met the inclusion criteria. The data were collected using a “Personal Information Form” and
the “Jessa Atrial Fibrillation Knowledge Questionnaire (JAKQ).
Results: The exploratory factor analysis carried out to determine the construct validity of the scale showed
that it had a three-dimensional structure and that its factor loads were within the appropriate range. The
internal consistency analyses of the scale revealed that the Cronbach’s alpha coefficient was 0.84 and that the
item-total score correlations were at an adequate level. The correlation value of the test-retest conducted to
test the time invariance of the scale was found to be 0.87, and there was a statistically significant relationship
between the two applications (P < .001).
Conclusion: The study results showed that the structure of the Turkish version of the Jessa Atrial Fibrillation
Questionnaire was similar to the structure of the original scale, that its validity and reliability were
considerably high and that it could be used in Turkey.
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