Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever

Akar, Servet; TUNCA, Mehmet; ARICAN, Özlem; AKDENİZ, Bahri; Güneri, Sema; Birlik, Merih; ÖNEN, Fatoş; Akkoç, Nurullah; Sari, Ismail; CAN, GERÇEK

Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever

İsmail SARI, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Romatoloji Anabilim Dalı, İzmir, Türkiye)

Özlem ARICAN, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Gerçek CAN, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Romatoloji Anabilim Dalı, İzmir, Türkiye)

Bahri AKDENİZ, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Servet AKAR, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Romatoloji Anabilim Dalı, İzmir, Türkiye)

AHMET MERİH BİRLİK, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Romatoloji Anabilim Dalı, İzmir, Türkiye)

Mehmet TUNCA, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, İzmir, Türkiye)

Nurullah AKKOÇ, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Romatoloji Anabilim Dalı, İzmir, Türkiye)

Sema GÜNERİ, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Fatoş ÖNEN (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Romatoloji Anabilim Dalı, İzmir, Türkiye)

Anadolu Kardiyoloji Dergisi

3 0

Yıl: 2008 Cilt: 8 Sayı: 4 Sayfa Aralığı: 271 - 278 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever

Öz:

Amaç: Bu çalışmada Ailevi Akdeniz Ateşi (AAA) hastalarında aortun elastik özelliklerinin, ventrikül fonksiyonlarının ve perikardiyal efüzyon varlığının değerlendirilmesini amaçladık. Yöntemler: Bu vaka-kontrollü, enine-kesitsel çalışmada 44 AAA hastası ve 27 sağlıklı birey yer aldı. Hipertansiyon, diyabet ve dislipidemisi olan bireyler çalışmaya alınmadı. Sağ ve sol ventrikül fonksiyonlarının değerlendirilmesinde 2-boyutlu, M-mod, standart ve doku Doppler ekokardiyografi incelemeleri kullanıldı. Aortun elastik özelliklerinin incelenmesinde 2-boyutlu ve M-mod ekokardiyografi kullanıldı. İstatistiksel değerlendirmede Mann Whitney U, Fisher testi ve Spearman korelasyonu kullanıldı. Bulgular: Hasta ve kontrol grubu yaş, cins, sigara kullanma durumu, vücut kitle indeksi- ve serum lipid düzeyleri açısından benzer özellikteydi (p>0.05). Çalışma grubundaki hiçbir bireyde perikardit ve/veya perikardiyal efüzyonla ilişkin bulguya rastlanmadı. Aortik elastik fonksiyon parametreleri hasta ve kontrol gurupları arasında benzerdi (p>0.05). Doku Doppler ile elde edilen sol ventrikül mitral annuler Em/Am oranı hasta grubunda kontrollere göre anlamlı olarak düşüktü [1.77 (0.6-3.4) karşı 1.79 (0.9-4.8) p=0.02]. Öte yandan mitral renkli M-mod akım yayılma hızı (Vp) hasta grubunda anlamlı olarak kısa bulundu [63 (39-100) karşı 74 (40-94) cm/s, p=0.008]. Triküspid annuler düzlem sistolik hareketi (TAPSE) değeri AAA hastalarında kontrollere göre belirgin düşüktü [2 (1.3-2.5) vs. 2.5 (1.7-3.2) cm; p<0.001]. Sekiz AAA hastası ve bir kontrolde TAPSE değeri <2 cm bulundu (p=0.025). Standart Doppler değerlendirmesi ile sağ ventrikül fonksiyonlarında hasta ve kontrol grubu arasında fark izlenmezken doku Doppler ile elde edilen değerlendirmede AAA hastalarında artmış sağ ventrikül diyastolik disfonksiyonu vardı (Em/Am<1; 19 AAA vs. 0 kontrol, p<0.001). Sonuç: Bu çalışmadaki bulgular klasik kardiyovasküler risk faktörü olmayan ve nispeten genç yaştaki AAA hastalarında subklinik bir miyokardiyal tutulumu düşündürtmektedir. Öte yandan aort ve perikardiyumun bu hastalarda etkilenmediği gözlenmiştir.

Anahtar Kelime: Perikardiyal efüzyon Kan akım hızı Kesitsel çalışmalar Mitral kapak Elastikiyet Ekokardiyografi Olgu-kontrol çalışmaları Aort Ventriküler fonksiyon Ekokardiyografi, doppler Ailesel akdeniz ateşi Triküspit kapak

Konular: Kalp ve Kalp Damar Sistemi

Ailevi Akdeniz ateşinde aortik sertleşme parametrelerinin ve ventrikül fonksiyonlarının değerlendirilmesi

Öz:

Objective: To investigate systolic and diastolic ventricular functions, aortic elastic properties and the presence of pericardial effusion in familial Mediterranean fever (FMF) patients.Methods: A case-controlled, cross-sectional study was performed on 44 FMF patients and 27 controls. Subjects with hypertension, diabetesmellitus and hyperlipidemia were excluded. Left and right ventricular functions were measured using echocardiography including two-dimensional, M-mode, and conventional Doppler as well as pulsed wave tissue Doppler imaging (TDI). Aortic elasticity was analyzed using M-mode tracing guided by the two-dimensional echocardiography. Statistical analysis was performed using Mann Whitney U, Spearman rho correlation and Fisher's exact tests. Results: Age, sex, body mass index, smoking status and lipids were comparable in patients and controls (p>0.05). None of the subjects hadpericarditis and/or pericardial effusion. Aortic wall properties were similar between groups (p>0.05). The TDI parameters of mitral lateral annulus revealed significantly lower Em/Am ratios in patients compared to controls [1.77 (0.6-3.4) vs. 1.79 (0.9-4.8), p=0.02]. Mitral flow propagationvelocity was significantly lower in patients than healthy subjects [63 (39-100) vs. 74 (40-94) cm/s, p=0.008]. Tricuspid annular plane systolicexcursion (TAPSE) was significantly reduced in FMF group than in controls [2 (1.3-2.5) vs. 2.5 (1.7-3.2) cm; p<0.001]. Eight of the patients and one control had impaired TAPSE (<2 cm; p=0.025). There was no difference regarding right ventricular diastolic dysfunction (RVDD) as assessed by using standard Doppler echocardiography (p>0.05). However, pronounced RVDD was observed in FMF patients documented by TDI (Em/Am<1; 19 patients vs. 0 controls, p<0.001). Conclusion: Subclinical myocardial involvement is present in a cohort of relatively young FMF patients who were also free of classicalcardiovascular risk factors. Pericardium and aorta seem to be spared during attack free periods of FMF.

Anahtar Kelime: Elasticity Echocardiography Case-Control Studies Aorta Ventricular Function Echocardiography, Doppler Familial Mediterranean Fever Tricuspid Valve Pericardial Effusion Blood Flow Velocity Cross-Sectional Studies Mitral Valve

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Sari I, ARICAN Ö, CAN G, AKDENİZ B, Akar S, Birlik M, TUNCA M, Akkoç N, Güneri S, ÖNEN F (2008). Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever. , 271 - 278.
Chicago	Sari Ismail,ARICAN Özlem,CAN GERÇEK,AKDENİZ Bahri,Akar Servet,Birlik Merih,TUNCA Mehmet,Akkoç Nurullah,Güneri Sema,ÖNEN Fatoş Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever. (2008): 271 - 278.
MLA	Sari Ismail,ARICAN Özlem,CAN GERÇEK,AKDENİZ Bahri,Akar Servet,Birlik Merih,TUNCA Mehmet,Akkoç Nurullah,Güneri Sema,ÖNEN Fatoş Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever. , 2008, ss.271 - 278.
AMA	Sari I,ARICAN Ö,CAN G,AKDENİZ B,Akar S,Birlik M,TUNCA M,Akkoç N,Güneri S,ÖNEN F Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever. . 2008; 271 - 278.
Vancouver	Sari I,ARICAN Ö,CAN G,AKDENİZ B,Akar S,Birlik M,TUNCA M,Akkoç N,Güneri S,ÖNEN F Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever. . 2008; 271 - 278.
IEEE	Sari I,ARICAN Ö,CAN G,AKDENİZ B,Akar S,Birlik M,TUNCA M,Akkoç N,Güneri S,ÖNEN F "Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever." , ss.271 - 278, 2008.
ISNAD	Sari, Ismail vd. "Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever". (2008), 271-278.

APA	Sari I, ARICAN Ö, CAN G, AKDENİZ B, Akar S, Birlik M, TUNCA M, Akkoç N, Güneri S, ÖNEN F (2008). Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever. Anadolu Kardiyoloji Dergisi, 8(4), 271 - 278.
Chicago	Sari Ismail,ARICAN Özlem,CAN GERÇEK,AKDENİZ Bahri,Akar Servet,Birlik Merih,TUNCA Mehmet,Akkoç Nurullah,Güneri Sema,ÖNEN Fatoş Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever. Anadolu Kardiyoloji Dergisi 8, no.4 (2008): 271 - 278.
MLA	Sari Ismail,ARICAN Özlem,CAN GERÇEK,AKDENİZ Bahri,Akar Servet,Birlik Merih,TUNCA Mehmet,Akkoç Nurullah,Güneri Sema,ÖNEN Fatoş Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever. Anadolu Kardiyoloji Dergisi, vol.8, no.4, 2008, ss.271 - 278.
AMA	Sari I,ARICAN Ö,CAN G,AKDENİZ B,Akar S,Birlik M,TUNCA M,Akkoç N,Güneri S,ÖNEN F Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever. Anadolu Kardiyoloji Dergisi. 2008; 8(4): 271 - 278.
Vancouver	Sari I,ARICAN Ö,CAN G,AKDENİZ B,Akar S,Birlik M,TUNCA M,Akkoç N,Güneri S,ÖNEN F Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever. Anadolu Kardiyoloji Dergisi. 2008; 8(4): 271 - 278.
IEEE	Sari I,ARICAN Ö,CAN G,AKDENİZ B,Akar S,Birlik M,TUNCA M,Akkoç N,Güneri S,ÖNEN F "Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever." Anadolu Kardiyoloji Dergisi, 8, ss.271 - 278, 2008.
ISNAD	Sari, Ismail vd. "Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever". Anadolu Kardiyoloji Dergisi 8/4 (2008), 271-278.